Proton-coupled di- and tri-peptide cotransport

Stable Identifier
Reaction [transition]
Homo sapiens
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The prototypical transporters of the SLC15 gene family are PEPT1 and PEPT2, which mediate the uptake of every possible di- and tri-peptide. PEPT1 (PTR1) is expressed mainly in the intestine (Liang R et al, 1995; Saito H et al, 1997) while PEPT2 (PTR2) is expressed in the kidney (Liu W et al, 1995).

Literature References
PubMed ID Title Journal Year
7756356 Molecular cloning of PEPT 2, a new member of the H+/peptide cotransporter family, from human kidney

Ganapathy, ME, Leibach, FH, Ganapathy, V, Hediger, MA, Liang, R, Ramamoorthy, S, Fei, YJ, Liu, W

Biochim Biophys Acta 1995
7896779 Human intestinal H+/peptide cotransporter. Cloning, functional expression, and chromosomal localization

Han, H, Leibach, FH, Ganapathy, V, Yang-Feng, TL, Hediger, MA, Liang, R, Ramamoorthy, S, Prasad, PD, Fei, YJ

J Biol Chem 1995
9299407 Cloning and characterization of a pH-sensing regulatory factor that modulates transport activity of the human H+/peptide cotransporter, PEPT1

Mukai, M, Saito, H, Motohashi, H, Inui, K

Biochem Biophys Res Commun 1997
Catalyst Activity

peptide:proton symporter activity of PEPT cotransporters [plasma membrane]

Orthologous Events
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