SLC25A1 transports di-/tri-peptides and peptide-like drugs

Stable Identifier
R-HSA-427998
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
SLC15A1 imports di-, tri-peptides and some peptide-like substances across the apical membrane of intestinal (duodenum, jejunum and ileum), kidney and bile duct epithelial cells, as well as into lysosomes. As a proton is cotransported, the process depends on membrane potential. SLC15A1 is a member of the proton-coupled oligopeptide transporter family (SLC15) (Liang R et al, 1995; Saito H et al, 1997; Knutter et al., 2008; reviewed in Daniel & Kottra, 2004; Smith et al., 2013). For a general discussion of diffusion of lipophilic drugs through the apical membrane's phospholipid bilayer see Kell & Oliver, 2014.
Literature References
PubMed ID Title Journal Year
7896779 Human intestinal H+/peptide cotransporter. Cloning, functional expression, and chromosomal localization

Han, H, Leibach, FH, Ganapathy, V, Yang-Feng, TL, Hediger, MA, Liang, R, Ramamoorthy, S, Prasad, PD, Fei, YJ

J Biol Chem 1995
9299407 Cloning and characterization of a pH-sensing regulatory factor that modulates transport activity of the human H+/peptide cotransporter, PEPT1

Mukai, M, Saito, H, Motohashi, H, Inui, K

Biochem Biophys Res Commun 1997
12905028 The proton oligopeptide cotransporter family SLC15 in physiology and pharmacology

Daniel, H, Kottra, G

Pflugers Arch 2004
23506874 Proton-coupled oligopeptide transporter family SLC15: physiological, pharmacological and pathological implications

Smith, DE, Hediger, MA, Clémençon, B

Mol Aspects Med 2013
25400580 How drugs get into cells: tested and testable predictions to help discriminate between transporter-mediated uptake and lipoidal bilayer diffusion

Kell, DB, Oliver, SG

Front Pharmacol 2014
18713951 Transport of angiotensin-converting enzyme inhibitors by H+/peptide transporters revisited

Kottra, G, Daniel, H, Zebisch, K, Hahn, MG, Fischer, W, Neubert, RH, Brandsch, M, Wollesky, C, Knütter, I

J Pharmacol Exp Ther 2008
Participants
Participates
Catalyst Activity

peptide:proton symporter activity of SLC15A1 [plasma membrane]

Orthologous Events
Cross References
RHEA
Authored
Reviewed
Created
Cite Us!