Proton-coupled di- and tri-peptide cotransport

Stable Identifier
R-HSA-427998
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The prototypical transporters of the SLC15 gene family are PEPT1 and PEPT2, which mediate the uptake of every possible di- and tri-peptide. PEPT1 (PTR1) is expressed mainly in the intestine (Liang R et al, 1995; Saito H et al, 1997) while PEPT2 (PTR2) is expressed in the kidney (Liu W et al, 1995).

Literature References
PubMed ID Title Journal Year
7896779 Human intestinal H+/peptide cotransporter. Cloning, functional expression, and chromosomal localization

Liang, R, Fei, YJ, Prasad, PD, Ramamoorthy, S, Han, H, Yang-Feng, TL, Hediger, MA, Ganapathy, V, Leibach, FH

J Biol Chem 1995
7756356 Molecular cloning of PEPT 2, a new member of the H+/peptide cotransporter family, from human kidney

Liu, W, Liang, R, Ramamoorthy, S, Fei, YJ, Ganapathy, ME, Hediger, MA, Ganapathy, V, Leibach, FH

Biochim Biophys Acta 1995
9299407 Cloning and characterization of a pH-sensing regulatory factor that modulates transport activity of the human H+/peptide cotransporter, PEPT1

Saito, H, Motohashi, H, Mukai, M, Inui, K

Biochem Biophys Res Commun 1997
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
peptide:proton symporter activity of PEPT cotransporters [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
Cite Us!