SLC26A3,6 exchange Cl- for HCO3-

Stable Identifier
R-HSA-427666
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Group 2 - Cl-/HCO3- exchanger transport
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The proteins responsible for the exchange of chloride (Cl-) with bicarbonate (HCO3-) are members of the SLC4 (1-3) and SLC26 (3 and 6) transporter families. SLC4 members are discussed in the section "Bicarbonate transporters".

SLC26A3 (Chloride anion exchanger, Down-regulated in adenoma, DRA) is expressed in the mucosa of the colon and helps mediate electrolyte and fluid absorption (Schweinfest et al. 1993). Defects in SLC26A3 cause congenital chloride diarrhea 1 (DIAR1), a disease characterized by watery stools containing an excess of chloride (Hoeglund et al. 1996). SLC26A6 encodes a protein involved in transporting chloride, oxalate, sulfate and bicarbonate (Waldegger et al. 2001). It is ubiquitously expressed, the highest levels present in kidney and pancreas.

Literature References
PubMed ID Title Journal Year
11247665 Cloning and characterization of SLC26A6, a novel member of the solute carrier 26 gene family

Waldegger, S, Moschen, I, Ramirez, A, Smith, RJ, Ayadi, H, Lang, F, Kubisch, C

Genomics 2001
7683425 Identification of a colon mucosa gene that is down-regulated in colon adenomas and adenocarcinomas

Schweinfest, CW, Henderson, KW, Suster, S, Kondoh, N, Papas, TS

Proc Natl Acad Sci U S A 1993
11834742 Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9

Lohi, H, Kujala, M, Makela, S, Lehtonen, E, Kestila, M, Saarialho-Kere, U, Markovich, D, Kere, J

J Biol Chem 2002
8896562 Mutations of the Down-regulated in adenoma (DRA) gene cause congenital chloride diarrhoea

Höglund, P, Haila, S, Socha, J, Tomaszewski, L, Saarialho-Kere, U, Karjalainen-Lindsberg, ML, Airola, K, Holmberg, C, de la Chapelle, A, Kere, J

Nat Genet 1996
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
inorganic anion exchanger activity of SLC26A3,6 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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