The proteins responsible for the exchange of chloride (Cl-) with bicarbonate (HCO3-) are members of the SLC4 (1-3) and SLC26 (3 and 6) transporter families. SLC4 members are discussed in the section "Bicarbonate transporters".SLC26A3 (Chloride anion exchanger, Down-regulated in adenoma, DRA) is expressed in the mucosa of the colon and helps mediate electrolyte and fluid absorption (Schweinfest et al. 1993). Defects in SLC26A3 cause congenital chloride diarrhea 1 (DIAR1), a disease characterized by watery stools containing an excess of chloride (Hoeglund et al. 1996). SLC26A6 encodes a protein involved in transporting chloride, oxalate, sulfate and bicarbonate (Waldegger et al. 2001). It is ubiquitously expressed, the highest levels present in kidney and pancreas.
Waldegger, S, Moschen, I, Ramirez, A, Smith, RJ, Ayadi, H, Lang, F, Kubisch, C
Schweinfest, CW, Henderson, KW, Suster, S, Kondoh, N, Papas, TS
Lohi, H, Kujala, M, Makela, S, Lehtonen, E, Kestila, M, Saarialho-Kere, U, Markovich, D, Kere, J
Höglund, P, Haila, S, Socha, J, Tomaszewski, L, Saarialho-Kere, U, Karjalainen-Lindsberg, ML, Airola, K, Holmberg, C, de la Chapelle, A, Kere, J
inorganic anion exchanger activity of SLC26A3,6 [plasma membrane]
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