Group 3 - Selective Cl- transport

Stable Identifier
R-HSA-427570
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Group 3 members (SLC26A7 and 9) function as ion channels. SLC26A7 encodes an ion channel which is abundantly expressed in medullary collecting duct cells of the kidney, high endothelial venule enothelial cells (HEVEC) and gastric parietal cells (Vincourt JB et al, 2002; Lohi H et al, 2002). SLC26A9 encodes an ion channel which is predominantly expressed on the lumenal side of the bronchiolar and alveolar epithelium of lung (Lohi H et al, 2002). Both these ion channels appear to transport Cl- without cotransport of HCO3- (Kim KH et al, 2005; Dorwart MR et al, 2007).

Literature References
PubMed ID Title Journal Year
11834742 Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9

Lohi, H, Kujala, M, Makela, S, Lehtonen, E, Kestila, M, Saarialho-Kere, U, Markovich, D, Kere, J

J Biol Chem 2002
17673510 SLC26A9 is a Cl(-) channel regulated by the WNK kinases

Dorwart, MR, Shcheynikov, N, Wang, Y, Stippec, S, Muallem, S

J Physiol 2007
15591059 SLC26A7 is a Cl- channel regulated by intracellular pH

Kim, KH, Shcheynikov, N, Wang, Y, Muallem, S

J Biol Chem 2005
11829495 Molecular cloning of SLC26A7, a novel member of the SLC26 sulfate/anion transporter family, from high endothelial venules and kidney

Vincourt, JB, Jullien, D, Kossida, S, Amalric, F, Girard, JP

Genomics 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
chloride channel activity of SLC26 chloride transporters [plasma membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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