Group 3 - Selective Cl- transport

Stable Identifier
Reaction [transition]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Group 3 members (SLC26A7 and 9) function as ion channels. SLC26A7 encodes an ion channel which is abundantly expressed in medullary collecting duct cells of the kidney, high endothelial venule enothelial cells (HEVEC) and gastric parietal cells (Vincourt JB et al, 2002; Lohi H et al, 2002). SLC26A9 encodes an ion channel which is predominantly expressed on the lumenal side of the bronchiolar and alveolar epithelium of lung (Lohi H et al, 2002). Both these ion channels appear to transport Cl- without cotransport of HCO3- (Kim KH et al, 2005; Dorwart MR et al, 2007).
Literature References
PubMed ID Title Journal Year
17673510 SLC26A9 is a Cl(-) channel regulated by the WNK kinases

Shcheynikov, N, Wang, Y, Dorwart, MR, Muallem, S, Stippec, S

J Physiol 2007
11834742 Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9

Makela, S, Kestila, M, Markovich, D, Kere, J, Saarialho-Kere, U, Lehtonen, E, Kujala, M, Lohi, H

J Biol Chem 2002
15591059 SLC26A7 is a Cl- channel regulated by intracellular pH

Shcheynikov, N, Kim, KH, Wang, Y, Muallem, S

J Biol Chem 2005
11829495 Molecular cloning of SLC26A7, a novel member of the SLC26 sulfate/anion transporter family, from high endothelial venules and kidney

Jullien, D, Girard, JP, Kossida, S, Vincourt, JB, Amalric, F

Genomics 2002
Catalyst Activity

chloride channel activity of SLC26 chloride transporters [plasma membrane]

Orthologous Events
Cross References
Cite Us!