Reactome | Group 3 - Selective Cl- transport

Group 3 - Selective Cl- transport

Stable Identifier

R-HSA-427570

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Group 3 members (SLC26A7 and 9) function as ion channels. SLC26A7 encodes an ion channel which is abundantly expressed in medullary collecting duct cells of the kidney, high endothelial venule enothelial cells (HEVEC) and gastric parietal cells (Vincourt JB et al, 2002; Lohi H et al, 2002). SLC26A9 encodes an ion channel which is predominantly expressed on the lumenal side of the bronchiolar and alveolar epithelium of lung (Lohi H et al, 2002). Both these ion channels appear to transport Cl- without cotransport of HCO3- (Kim KH et al, 2005; Dorwart MR et al, 2007).

Literature References

PubMed ID	Title	Journal	Year
17673510	SLC26A9 is a Cl(-) channel regulated by the WNK kinases Shcheynikov, N, Wang, Y, Dorwart, MR, Muallem, S, Stippec, S	J Physiol	2007
11834742	Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9 Makela, S, Kestila, M, Markovich, D, Kere, J, Saarialho-Kere, U, Lehtonen, E, Kujala, M, Lohi, H	J Biol Chem	2002
15591059	SLC26A7 is a Cl- channel regulated by intracellular pH Shcheynikov, N, Kim, KH, Wang, Y, Muallem, S	J Biol Chem	2005
11829495	Molecular cloning of SLC26A7, a novel member of the SLC26 sulfate/anion transporter family, from high endothelial venules and kidney Jullien, D, Girard, JP, Kossida, S, Vincourt, JB, Amalric, F	Genomics	2002