eNoSC deacetylates histone H3

Stable Identifier
Reaction [transition]
Homo sapiens
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The Sirtuin-1 (SIRT1) component of eNoSC deacetylates histone H3 at lysine-9 (Vaquero et al. 2004, Murayama et al. 2008). The reaction uses nicotinamide adenine dinucleotide (NAD) as the acceptor of the acetyl group and generates nicotinamide and 1-O-acetyl-ADP-ribose as products (Vaquero et al. 2004). The use of NAD links the reaction to the overall energy balance of the cell. Cells exposed to high glucose have a greater NADH:NAD ratio and therefore lower activity of eNoSC (Murayama et al. 2008). Low glucose produces higher NAD and higher activity of eNoSC.

Literature References
PubMed ID Title Journal Year
18485871 Epigenetic control of rDNA loci in response to intracellular energy status

Fujimura, A, Murayama, A, Minami, H, Nagata, K, Kuroda, T, Kimura, K, Oie, S, Ohmori, K, Yasuzawa-Tanaka, K, Daitoku, H, Yanagisawa, J, Fukamizu, A, Okuwaki, M, Shimizu, T

Cell 2008
15469825 Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin

Scher, M, Reinberg, D, Lee, D, Tempst, P, Vaquero, A, Erdjument-Bromage, H

Mol. Cell 2004
Catalyst Activity

histone deacetylase activity of eNoSC [nucleoplasm]

Orthologous Events
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