MBD2 binds methylcytosine in chromatin

Stable Identifier
R-HSA-427337
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Methyl Binding Domain protein 2 (MBD2) binds 5-methylcytosine residues in DNA (Ng et al. 1999) and may recruit further silencing complexes. MBD2 has been shown to specifically bind 5-methylcytosine in the promoters of rRNA gene copies to reduce promoter activity (Ghoshal et al. 2004).

Literature References
PubMed ID Title Journal Year
14610093 Role of human ribosomal RNA (rRNA) promoter methylation and of methyl-CpG-binding protein MBD2 in the suppression of rRNA gene expression

Ghoshal, K, Majumder, S, Datta, J, Motiwala, T, Bai, S, Sharma, SM, Frankel, W, Jacob, ST

J Biol Chem 2004
10471499 MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex

Ng, HH, Zhang, Y, Hendrich, B, Johnson, CA, Turner, BM, Erdjument-Bromage, H, Tempst, P, Reinberg, D, Bird, A

Nat. Genet. 1999
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