Reactome | MBD2 binds methylcytosine in chromatin

MBD2 binds methylcytosine in chromatin

Stable Identifier

R-HSA-427337

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Methyl Binding Domain protein 2 (MBD2) binds 5-methylcytosine residues in DNA (Ng et al. 1999) and may recruit further silencing complexes. MBD2 has been shown to specifically bind 5-methylcytosine in the promoters of rRNA gene copies to reduce promoter activity (Ghoshal et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
10471499	MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex Ng, HH, Zhang, Y, Hendrich, B, Johnson, CA, Turner, BM, Erdjument-Bromage, H, Tempst, P, Reinberg, D, Bird, A	Nat. Genet.	1999
14610093	Role of human ribosomal RNA (rRNA) promoter methylation and of methyl-CpG-binding protein MBD2 in the suppression of rRNA gene expression Ghoshal, K, Majumder, S, Datta, J, Motiwala, T, Bai, S, Sharma, SM, Frankel, W, Jacob, ST	J Biol Chem	2004