DAG kinase produces phosphatidic acid from DAG

Stable Identifier
R-HSA-426240
Type
Reaction [transition]
Species
Homo sapiens
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Diacylglycerol kinases (DGKs) are intracellular lipid kinases that use ATP to phosphorylate diacylglycerol (DAG)., generating phosphatidic acid (PA). This lowers membrane DAG levels, regulating signalling proteins that require DAG for membrane association such as Protein Kinase C. PA is a signalling molecule that regulates Raf-1 and PKC zeta, and a substrate for the resynthesis of phosphatidylinositol.

Literature References
PubMed ID Title Journal Year
2175712 Purification, cDNA-cloning and expression of human diacylglycerol kinase

Schaap, D, de Widt, J, van der Wal, J, Vandekerckhove, J, van Damme, J, Gussow, D, Ploegh, HL, van Blitterswijk, WJ, van der Bend, RL

FEBS Lett 1990
11080611 Properties and functions of diacylglycerol kinases

van Blitterswijk, WJ, Houssa, B

Cell Signal 2000
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Catalyst Activity
Title
diacylglycerol kinase activity of Diacylglycerol kinase [plasma membrane]
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