Diacylglycerol kinases (DGKs) are intracellular lipid kinases that use ATP to phosphorylate diacylglycerol (DAG)., generating phosphatidic acid (PA). This lowers membrane DAG levels, regulating signalling proteins that require DAG for membrane association such as Protein Kinase C. PA is a signalling molecule that regulates Raf-1 and PKC zeta, and a substrate for the resynthesis of phosphatidylinositol.
Schaap, D, de Widt, J, van der Wal, J, Vandekerckhove, J, van Damme, J, Gussow, D, Ploegh, HL, van Blitterswijk, WJ, van der Bend, RL
van Blitterswijk, WJ, Houssa, B
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