Reactome | DAG kinase produces phosphatidic acid from DAG

DAG kinase produces phosphatidic acid from DAG

Stable Identifier

R-HSA-426240

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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DAG kinase produces phosphatidic acid from DAG

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Diacylglycerol kinases (DGKs) are intracellular lipid kinases that use ATP to phosphorylate diacylglycerol (DAG)., generating phosphatidic acid (PA). This lowers membrane DAG levels, regulating signalling proteins that require DAG for membrane association such as Protein Kinase C. PA is a signalling molecule that regulates Raf-1 and PKC zeta, and a substrate for the resynthesis of phosphatidylinositol.

Literature References

PubMed ID	Title	Journal	Year
11080611	Properties and functions of diacylglycerol kinases van Blitterswijk, WJ, Houssa, B	Cell Signal	2000
2175712	Purification, cDNA-cloning and expression of human diacylglycerol kinase Schaap, D, de Widt, J, van der Wal, J, Vandekerckhove, J, van Damme, J, Gussow, D, Ploegh, HL, van Blitterswijk, WJ, van der Bend, RL	FEBS Lett	1990