Reactome | DAG activation of TRPC channels

DAG activation of TRPC channels

Stable Identifier

R-HSA-426209

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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TRPC3, 6 and 7 are non-selective cation channels that are activated by diacylglycerol (DAG) independently of protein kinase C activation by DAG. By analogy with the structures of voltage-regulated calcium channels, TRPC channels are probably tetramers of TRPC protein; heterotetramers within the 3/6/7 group have been observed.

Literature References

PubMed ID	Title	Journal	Year
11805119	Cloning and functional expression of human short TRP7, a candidate protein for store-operated Ca2+ influx Randall, AD, Riccio, A, Davis, JB, Mattei, C, Benham, CD, Medhurst, AD, Calver, AR, Kelsell, RE, Pangalos, MN	J Biol Chem	2002
9930701	Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol Schultz, G, Hofmann, T, Harteneck, C, Gudermann, T, Obukhov, AG, Schaefer, M	Nature	1999