DAG is metabolized by DAGL to 2-AG

Stable Identifier
R-HSA-426032
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Diacylglycerol lipase (DAGL) hydrolyzes diacylglycerol (DAG) at the sn-1 position, producing 2-monoacylglycerols, including 2-arachidonlyglycerol (2-AG) and free fatty acid. This reaction was first characterised for the release of arachidonate from membrane phospholipids in platelets, but is also involved in the spatial and temporal regulation of endocannabinoid signaling in the brain. DAGL exhibits strong selectivity for diacylglycerols over phospholipids, monoacylglycerols, triacylglycerols and fatty acid amides, and prefers the acyl group at sn-1 position to that at sn-2.

Literature References
PubMed ID Title Journal Year
10348910 Purification and characterization of diacylglycerol lipase from human platelets

Moriyama, T, Urade, R, Kito, M

J Biochem 1999
19126434 Biology of endocannabinoid synthesis system

Wang, J, Ueda, N

Prostaglandins Other Lipid Mediat 2008
Participants
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Catalyst Activity
Catalyst Activity
Title
acylglycerol lipase activity of Diacylglycerol lipase [plasma membrane]
Physical Entity
Activity
Orthologous Events
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