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Activation of Protein Kinase C novel isoforms
Stable Identifier
R-HSA-425861
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Effects of PIP2 hydrolysis (Homo sapiens)
Activation of Protein Kinase C novel isoforms (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Effects of PIP2 hydrolysis (Homo sapiens)
Activation of Protein Kinase C novel isoforms (Homo sapiens)
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Activation of the novel Protein Kinase C (nPKC) isoforms (delta, epsilon, eta and theta) requires binding to the membrane lipid diacylglycerol (DAG). nPKC activation is sensitive to DAG concentration.
Literature References
PubMed ID
Title
Journal
Year
Protein Kinase C 2nd ed
Dekker, L
2004
19033211
Lipid activation of protein kinases
Newton, AC
J Lipid Res
2009
9601053
The extended protein kinase C superfamily
Mellor, H
,
Parker, PJ
Biochem J
1998
Participants
Input
DAG [plasma membrane]
Protein kinase C, novel isoforms [cytosol]
(Homo sapiens)
Output
Protein kinase C, novel isoforms:DAG [plasma membrane]
(Homo sapiens)
Participates
as an event of
Effects of PIP2 hydrolysis (Homo sapiens)
Orthologous Events
Activation of Protein Kinase C novel isoforms (Bos taurus)
Activation of Protein Kinase C novel isoforms (Caenorhabditis elegans)
Activation of Protein Kinase C novel isoforms (Canis familiaris)
Activation of Protein Kinase C novel isoforms (Danio rerio)
Activation of Protein Kinase C novel isoforms (Dictyostelium discoideum)
Activation of Protein Kinase C novel isoforms (Drosophila melanogaster)
Activation of Protein Kinase C novel isoforms (Gallus gallus)
Activation of Protein Kinase C novel isoforms (Mus musculus)
Activation of Protein Kinase C novel isoforms (Rattus norvegicus)
Activation of Protein Kinase C novel isoforms (Saccharomyces cerevisiae)
Activation of Protein Kinase C novel isoforms (Schizosaccharomyces pombe)
Activation of Protein Kinase C novel isoforms (Sus scrofa)
Activation of Protein Kinase C novel isoforms (Xenopus tropicalis)
Authored
Akkerman, JW (2009-06-03)
Reviewed
Kunapuli, SP (2010-06-07)
Created
Jupe, S (2009-06-08)
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