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SLC8A1 [plasma membrane]
Stable Identifier
R-HSA-425681
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Sodium/calcium exchanger 1, NAC1_HUMAN
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet homeostasis (Homo sapiens)
Platelet calcium homeostasis (Homo sapiens)
Reduction of cytosolic Ca++ levels (Homo sapiens)
SLC8A1,2,3 exchange 3Na+ for Ca2+ (Homo sapiens)
SLC8A1,2,3 [plasma membrane] (Homo sapiens)
SLC8A1 [plasma membrane] (Homo sapiens)
Muscle contraction (Homo sapiens)
Cardiac conduction (Homo sapiens)
Ion homeostasis (Homo sapiens)
SLC8A1,2,3 exchange 3Na+ for Ca2+ (Homo sapiens)
SLC8A1,2,3 [plasma membrane] (Homo sapiens)
SLC8A1 [plasma membrane] (Homo sapiens)
Transport of small molecules (Homo sapiens)
SLC-mediated transmembrane transport (Homo sapiens)
Transport of inorganic cations/anions and amino acids/oligopeptides (Homo sapiens)
Sodium/Calcium exchangers (Homo sapiens)
SLC8A1,2,3 exchange 3Na+ for Ca2+ (Homo sapiens)
SLC8A1,2,3 [plasma membrane] (Homo sapiens)
SLC8A1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P32418 SLC8A1
Gene Names
SLC8A1, CNC, NCX1
Chain
signal peptide:1-35, chain:36-973
Reference Genes
BioGPS Gene:6546 SLC8A1
COSMIC (genes):SLC8A1 SLC8A1
CTD Gene:6546 SLC8A1
dbSNP Gene:6546 SLC8A1
ENSEMBL:ENSG00000183023 SLC8A1
ENSEMBL_homo_sapiens_GENE:ENSG00000183023.19 SLC8A1
HGNC:11068 SLC8A1
KEGG Gene (Homo sapiens):6546 SLC8A1
Monarch:6546 SLC8A1
NCBI Gene:6546 SLC8A1
OMIM:182305 SLC8A1
UCSC:P32418 SLC8A1
Reference Transcript
RefSeq:NM_001112801.1 SLC8A1
RefSeq:XM_017004751.1 SLC8A1
RefSeq:XM_017004750.1 SLC8A1
RefSeq:XM_011533055.2 SLC8A1
RefSeq:XM_011533054.2 SLC8A1
RefSeq:NM_001252624.1 SLC8A1
RefSeq:XM_006712081.2 SLC8A1
RefSeq:XM_017004758.1 SLC8A1
RefSeq:NM_001112800.1 SLC8A1
RefSeq:XM_017004749.1 SLC8A1
RefSeq:XM_017004754.1 SLC8A1
RefSeq:XM_017004748.1 SLC8A1
RefSeq:XM_006712085.3 SLC8A1
RefSeq:XM_005264514.3 SLC8A1
RefSeq:NM_001112802.1 SLC8A1
RefSeq:XM_006712084.3 SLC8A1
RefSeq:XM_017004753.1 SLC8A1
RefSeq:XM_017004752.1 SLC8A1
RefSeq:XM_017004746.1 SLC8A1
RefSeq:XM_011533056.1 SLC8A1
RefSeq:XM_006712083.3 SLC8A1
RefSeq:NM_021097.2 SLC8A1
RefSeq:XM_006712082.3 SLC8A1
Other Identifiers
11735152_a_at
11740612_a_at
1556583_PM_a_at
1556583_a_at
1561615_PM_s_at
1561615_s_at
1565306_PM_a_at
1565306_a_at
16896836
207053_PM_at
207053_at
210804_PM_x_at
210804_x_at
211805_PM_s_at
211805_s_at
235518_PM_at
235518_at
238546_PM_at
238546_at
241752_PM_at
241752_at
2549534
2549536
2549537
2549538
2549539
2549540
2549542
2549544
2549546
2549548
2549550
2549552
2549554
2549556
2549558
2549560
2549562
2549564
2549566
2549567
2549568
2549569
2549570
2549579
2549585
2549588
2549589
2549591
2549594
2549615
2549616
2549619
2549625
34915_at
49583_at
63700_at
6546
75637_at
77083_at
8051762
A_24_P136866
A_32_P110372
A_32_P147078
A_32_P9737
A_33_P3262156
GE58137
GE771003
GE86279
GO:0002026
GO:0002027
GO:0003012
GO:0003013
GO:0005215
GO:0005432
GO:0005509
GO:0005515
GO:0005516
GO:0005634
GO:0005654
GO:0005886
GO:0006811
GO:0006814
GO:0006816
GO:0006874
GO:0006883
GO:0006936
GO:0007154
GO:0008092
GO:0010468
GO:0010649
GO:0010881
GO:0010882
GO:0014069
GO:0014704
GO:0014829
GO:0015297
GO:0016020
GO:0023052
GO:0030018
GO:0030054
GO:0030154
GO:0030315
GO:0030424
GO:0030425
GO:0030501
GO:0030506
GO:0034614
GO:0035725
GO:0035994
GO:0036211
GO:0036376
GO:0042383
GO:0043025
GO:0043226
GO:0043679
GO:0044325
GO:0044557
GO:0045202
GO:0046872
GO:0048856
GO:0051481
GO:0055013
GO:0055065
GO:0055074
GO:0055085
GO:0055119
GO:0060048
GO:0060402
GO:0070509
GO:0070588
GO:0071313
GO:0071901
GO:0071944
GO:0086012
GO:0086064
GO:0097553
GO:0098703
GO:0098719
GO:0098735
GO:0098794
GO:1901660
GO:1903779
HMNXSV003046724
HMNXSV003049660
Hs.144465.0.A1_3p_at
Hs.154669.0.A1_3p_at
Hs.283691.0.S1_3p_at
Hs2.31961.1.S1_3p_s_at
Hs2.407280.1.S1_3p_s_at
Hs2.407280.4.S1_3p_a_at
ILMN_1699520
ILMN_1816603
M91368_s_at
PH_hs_0002715
PH_hs_0022586
TC02001769.hg
TC02004178.hg
X92368_at
g6453728_3p_a_at
Participates
as a member of
SLC8A1,2,3 [plasma membrane] (Homo sapiens)
Inferred To
NCX1 [plasma membrane]
(Gallus gallus)
Homologues of SLC8A1 [plasma membrane]
(Caenorhabditis elegans)
SLC8A1 [plasma membrane]
(Bos taurus)
SLC8A1 [plasma membrane]
(Canis familiaris)
SLC8A1 [plasma membrane]
(Drosophila melanogaster)
SLC8A1 [plasma membrane]
(Mus musculus)
SLC8A1 [plasma membrane]
(Rattus norvegicus)
SLC8A1 [plasma membrane]
(Sus scrofa)
ncx-1 [plasma membrane]
(Caenorhabditis elegans)
slc8a1b [plasma membrane]
(Danio rerio)
ncx-2 [plasma membrane]
(Caenorhabditis elegans)
slc8a1 [plasma membrane]
(Xenopus tropicalis)
Cross References
RefSeq
XP_006712144.1
,
XP_006712146.1
,
NP_001106271.1
,
XP_011531358.1
,
XP_016860239.1
,
XP_011531356.1
,
XP_016860242.1
,
XP_016860243.1
,
NP_001106273.1
,
XP_016860235.1
,
XP_016860237.1
,
XP_016860240.1
,
NP_066920.1
,
XP_006712145.1
,
XP_006712147.1
,
XP_006712148.1
,
XP_011531357.1
,
NP_001239553.1
,
XP_016860238.1
,
XP_016860241.1
,
NP_001106272.1
,
XP_016860247.1
,
XP_005264571.1
Guide to Pharmacology - Targets
945
OpenTargets
ENSG00000183023
HPA
ENSG00000183023-SLC8A1
GeneCards
P32418
ZINC target
P32418
Ensembl
ENSP00000516142
,
ENSP00000332931
,
ENSP00000385535
,
ENSP00000383886
,
ENST00000332839
,
ENSP00000385811
,
ENST00000406391
,
ENSP00000385678
,
ENST00000403092
,
ENSP00000384908
,
ENST00000705604
,
ENSP00000385188
,
ENSG00000183023
,
ENST00000405269
,
ENST00000408028
,
ENST00000402441
,
ENST00000405901
,
ENSP00000384763
,
ENST00000406785
PRO
P32418
Pharos - Targets
P32418
Orphanet
26269
PDB
8JP0
,
8SGT
,
8SGJ
HMDB Protein
HMDBP03051
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