Reactome | SLC8A2 [plasma membrane]

SLC8A2 [plasma membrane]

Stable Identifier

R-HSA-425656

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Sodium/calcium exchanger 2, NAC2_HUMAN

Locations in the PathwayBrowser

Expand all

Transport of small molecules (Homo sapiens)

- SLC-mediated transmembrane transport (Homo sapiens)
  - Transport of inorganic cations/anions and amino acids/oligopeptides (Homo sapiens)
    - Sodium/Calcium exchangers (Homo sapiens)
      - SLC8A1,2,3 exchange 3Na+ for Ca2+ (Homo sapiens)
        
        SLC8A1,2,3 [plasma membrane] (Homo sapiens)
        
        SLC8A2 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UPR5 SLC8A2

Gene Names

SLC8A2, KIAA1087, NCX2

Chain

signal peptide:1-20, chain:21-921

Reference Genes

BioGPS Gene:6543 SLC8A2

COSMIC (genes):SLC8A2 SLC8A2

CTD Gene:6543 SLC8A2

dbSNP Gene:6543 SLC8A2

ENSEMBL:ENSG00000118160 SLC8A2

ENSEMBL:ENSG00000118160.14 SLC8A2

HGNC:11069 SLC8A2

KEGG Gene (Homo sapiens):6543 SLC8A2

Monarch:6543 SLC8A2

NCBI Gene:6543 SLC8A2

OMIM:601901 SLC8A2

UCSC:Q9UPR5 SLC8A2

Reference Transcript

RefSeq:NM_015063.2 SLC8A2

Other Identifiers

11731409_at

11731410_a_at

11731411_a_at

11731412_x_at

11750448_a_at

16873718

215267_PM_s_at

215267_s_at

35592_at

3866542

3866543

3866544

3866545

3866546

3866548

3866551

3866553

3866554

3866558

3866561

3866562

3866563

3866564

3866565

3866566

6543

8037888

84722_at

A_23_P336954

A_32_P45844

A_33_P3319542

GE53739

GO:0002931

GO:0003013

GO:0005215

GO:0005432

GO:0005516

GO:0005886

GO:0006811

GO:0006814

GO:0006816

GO:0006874

GO:0007154

GO:0007611

GO:0007612

GO:0007613

GO:0010468

GO:0014069

GO:0015081

GO:0015085

GO:0015297

GO:0016020

GO:0016323

GO:0023052

GO:0030054

GO:0030424

GO:0030425

GO:0034330

GO:0035725

GO:0036211

GO:0042383

GO:0042995

GO:0043025

GO:0043197

GO:0043204

GO:0043226

GO:0043679

GO:0045202

GO:0046872

GO:0048172

GO:0050808

GO:0050877

GO:0050890

GO:0051480

GO:0055065

GO:0055085

GO:0060291

GO:0070050

GO:0070588

GO:0071902

GO:0098703

GO:0098793

GO:0098794

GO:0098815

GO:0099566

GO:0099608

GO:0106056

GO:0150104

GO:1903779

GO:1905060

GO:1990034

HMNXSV003019449

Hs.143026.0.S1_3p_s_at

ILMN_1698846

PH_hs_0022839

TC19001664.hg

Participates

as a member of

SLC8A1,2,3 [plasma membrane] (Homo sapiens)

Inferred To

slc8a2 [plasma membrane] (Xenopus tropicalis)

si:dkeyp-109h9.1 [plasma membrane] (Danio rerio)

ncx-1 [plasma membrane] (Caenorhabditis elegans)

Calx [plasma membrane] (Drosophila melanogaster)

Homologues of SLC8A2 [plasma membrane] (Caenorhabditis elegans)

SLC8A2 [plasma membrane] (Bos taurus)

SLC8A2 [plasma membrane] (Canis familiaris)

SLC8A2 [plasma membrane] (Gallus gallus)

SLC8A2 [plasma membrane] (Mus musculus)

SLC8A2 [plasma membrane] (Rattus norvegicus)

SLC8A2 [plasma membrane] (Sus scrofa)

ncx-2 [plasma membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_055878.1

Guide to Pharmacology - Targets

946

OpenTargets

ENSG00000118160

GeneCards

Q9UPR5

HPA

ENSG00000118160-SLC8A2

Ensembl

ENSP00000236877, ENSG00000118160, ENST00000236877

PRO

Q9UPR5

Pharos - Targets

Q9UPR5

HMDB Protein

HMDBP03171