Reactome | ST8SIA2 [Golgi membrane]

ST8SIA2 [Golgi membrane]

Stable Identifier

R-HSA-422392

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

Golgi membrane

Synonyms

STX (ST8SIA2), Alpha-2,8-sialyltransferase 8B, SIA8B_HUMAN

Locations in the PathwayBrowser

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Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - NCAM signaling for neurite out-growth (Homo sapiens)
      - NCAM1 interactions (Homo sapiens)
        
        Polysialylation of NCAM1 (Homo sapiens)
        
        alpha 2-8 polysialyltransferases [Golgi membrane] (Homo sapiens)
        
        ST8SIA2 [Golgi membrane] (Homo sapiens)

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Homo sapiens)
      - Synthesis of substrates in N-glycan biosythesis (Homo sapiens)
        
        Sialic acid metabolism (Homo sapiens)
        
        ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues (Homo sapiens)
        
        ST8SIA1-6 [Golgi membrane] (Homo sapiens)
        
        ST8SIA2 [Golgi membrane] (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - N-glycan antennae elongation in the medial/trans-Golgi (Homo sapiens)
        
        N-Glycan antennae elongation (Homo sapiens)
        
        ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans (Homo sapiens)
        
        ST8SIA2,3,6 [Golgi membrane] (Homo sapiens)
        
        ST8SIA2 [Golgi membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q92186 ST8SIA2

Gene Names

ST8SIA2, SIAT8B, STX

Chain

chain:1-375

Reference Genes

BioGPS Gene:8128 ST8SIA2

COSMIC (genes):ST8SIA2 ST8SIA2

CTD Gene:8128 ST8SIA2

dbSNP Gene:8128 ST8SIA2

ENSEMBL:ENSG00000140557 ST8SIA2

HGNC:10870 ST8SIA2

KEGG:hsa:8128 ST8SIA2

Monarch:8128 ST8SIA2

NCBI Gene:8128 ST8SIA2

OMIM:602546 ST8SIA2

UCSC:Q92186 ST8SIA2

Reference Transcript

RefSeq:NM_006011.3 ST8SIA2

Other Identifiers

11731084_at

11753223_a_at

16805192

16805205

221285_PM_at

221285_at

239537_PM_at

239537_at

3608956

3608957

3608958

3608978

3608981

3608983

3608984

3608986

3608987

3608989

3608990

3608991

3608992

3609003

3609005

3609006

3609008

3609009

3609010

3609011

3609012

61991_at

7986229

7986239

8128

85614_at

A_23_P117805

A_24_P664850

GE867725

GE891975

GO:0000139

GO:0000166

GO:0001574

GO:0003824

GO:0003828

GO:0005576

GO:0005768

GO:0005769

GO:0005794

GO:0005886

GO:0005975

GO:0006486

GO:0006491

GO:0006629

GO:0007399

GO:0008373

GO:0009311

GO:0016020

GO:0016740

GO:0016757

GO:0030154

GO:0030182

GO:0031410

GO:0033691

GO:0036211

GO:0042220

GO:0043226

GO:0043525

GO:0048471

GO:0048856

GO:0051965

GO:0055037

GO:0097503

GO:1901135

GO:1990138

HMNXSV003005254

Hs.146726.0.A1_3p_at

ILMN_1758461

PH_hs_0023613

PH_hs_0038039

TC15000883.hg

g5174676_3p_at

Participates

as a member of

Inferred To

ST8SIA2 [Golgi membrane] (Bos taurus)

ST8SIA2 [Golgi membrane] (Canis familiaris)

ST8SIA2 [Golgi membrane] (Gallus gallus)

ST8SIA2 [Golgi membrane] (Mus musculus)

ST8SIA2 [Golgi membrane] (Rattus norvegicus)

ST8SIA2 [Golgi membrane] (Sus scrofa)

st8sia2 [Golgi membrane] (Danio rerio)

st8sia2 [Golgi membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_006002.1

ENSEMBL

ENST00000268164, ENSP00000268164, ENSG00000140557

OpenTargets

ENSG00000140557

GeneCards

ST8SIA2

HPA

ENSG00000140557-ST8SIA2

PRO

Q92186

Pharos - Targets

Q92186

GlyGen

Q92186

HMDB Protein

HMDBP14212