Heterotrimeric G(s) complex dissociates

Stable Identifier
Reaction [dissociation]
Homo sapiens
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The binding of GTP by G(s) alpha causes the heterotrimeric G-protein complex to reorientate, exposing previously bound faces of the G(s) alpha:GTP complex and the G-beta: G-gamma complex. Unlike the case with Gi/o heterotrimers, Gs heterotrimers are not observed to significantly dissociate in living cells.

Literature References
PubMed ID Title Journal Year
15569269 Glucagon-like peptide-1: regulation of insulin secretion and therapeutic potential

Gromada, J, Brock, B, Schmitz, O, Rorsman, P

Basic Clin Pharmacol Toxicol 2004
18577758 Dissociation of heterotrimeric g proteins in cells

Lambert, NA

Sci Signal 2008
17095603 Some G protein heterotrimers physically dissociate in living cells

Digby, GJ, Lober, RM, Sethi, PR, Lambert, NA

Proc Natl Acad Sci U S A 2006
8405712 Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor

Thorens, B, Porret, A, Buhler, L, Deng, SP, Morel, P, Widmann, C

Diabetes 1993
17900700 G-protein-coupled receptors and islet function-implications for treatment of type 2 diabetes

Winzell, MS, Ahren, B

Pharmacol Ther 2007
17306374 Mechanisms of action of glucagon-like peptide 1 in the pancreas

Doyle, ME, Egan, JM

Pharmacol Ther 2007
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