Heterotrimeric G(s) complex dissociates

Stable Identifier
Reaction [transition]
Homo sapiens
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The binding of GTP by G(s) alpha causes the heterotrimeric G-protein complex to reorientate, exposing previously bound faces of the G(s) alpha:GTP complex and the G-beta: G-gamma complex. Unlike the case with Gi/o heterotrimers, Gs heterotrimers are not observed to significantly dissociate in living cells.
Literature References
PubMed ID Title Journal Year
18577758 Dissociation of heterotrimeric g proteins in cells

Lambert, NA

Sci Signal 2008
15569269 Glucagon-like peptide-1: regulation of insulin secretion and therapeutic potential

Brock, B, Gromada, J, Rorsman, P, Schmitz, O

Basic Clin Pharmacol Toxicol 2004
17095603 Some G protein heterotrimers physically dissociate in living cells

Lambert, NA, Digby, GJ, Sethi, PR, Lober, RM

Proc Natl Acad Sci U S A 2006
8405712 Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor

Morel, P, Widmann, C, Thorens, B, Porret, A, Buhler, L, Deng, SP

Diabetes 1993
17900700 G-protein-coupled receptors and islet function-implications for treatment of type 2 diabetes

Ahren, B, Winzell, MS

Pharmacol Ther 2007
17306374 Mechanisms of action of glucagon-like peptide 1 in the pancreas

Egan, JM, Doyle, ME

Pharmacol Ther 2007
Catalyst Activity

G protein activity of G-alpha(s):GTP:G-beta:G-gamma [plasma membrane]

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