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DecS-GHRL-1(24-51) [extracellular region]
Stable Identifier
R-HSA-422041
Type
Genes and Transcripts [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Decanoyl Ghrelin-28, Appetite-regulating hormone, GHRL, GHRL_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Peptide hormone metabolism (Homo sapiens)
Synthesis, secretion, and deacylation of Ghrelin (Homo sapiens)
Acyl Ghrelin and C-Ghrelin are secreted (Homo sapiens)
Acyl Ghrelin [extracellular region] (Homo sapiens)
DecS-GHRL-1(24-51) [extracellular region] (Homo sapiens)
Butyrylcholinesterase hydrolyzes acyl Ghrelin (Homo sapiens)
Acyl Ghrelin [extracellular region] (Homo sapiens)
DecS-GHRL-1(24-51) [extracellular region] (Homo sapiens)
Platelet-activating factor acetylhydrolase (PLA2G7) hydrolyzes acyl Ghrelin (Homo sapiens)
Acyl Ghrelin [extracellular region] (Homo sapiens)
DecS-GHRL-1(24-51) [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
Acyl ghrelin:GHSR [plasma membrane] (Homo sapiens)
Acyl Ghrelin [extracellular region] (Homo sapiens)
DecS-GHRL-1(24-51) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
Acyl ghrelin:GHSR [plasma membrane] (Homo sapiens)
Acyl Ghrelin [extracellular region] (Homo sapiens)
DecS-GHRL-1(24-51) [extracellular region] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
Acyl ghrelin:GHSR [plasma membrane] (Homo sapiens)
Acyl Ghrelin [extracellular region] (Homo sapiens)
DecS-GHRL-1(24-51) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
Acyl ghrelin:GHSR [plasma membrane] (Homo sapiens)
Acyl Ghrelin [extracellular region] (Homo sapiens)
DecS-GHRL-1(24-51) [extracellular region] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
Acyl ghrelin:GHSR [plasma membrane] (Homo sapiens)
Acyl Ghrelin [extracellular region] (Homo sapiens)
DecS-GHRL-1(24-51) [extracellular region] (Homo sapiens)
Ligands of GPCRs that activate Gq/11 [extracellular region] (Homo sapiens)
Acyl Ghrelin [extracellular region] (Homo sapiens)
DecS-GHRL-1(24-51) [extracellular region] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
GHSR is a receptor for ghrelin (Homo sapiens)
Acyl Ghrelin [extracellular region] (Homo sapiens)
DecS-GHRL-1(24-51) [extracellular region] (Homo sapiens)
Acyl ghrelin:GHSR [plasma membrane] (Homo sapiens)
Acyl Ghrelin [extracellular region] (Homo sapiens)
DecS-GHRL-1(24-51) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UBU3-1 GHRL
Gene Names
GHRL, MTLRP, UNQ524/PRO1066
Participates
as a member of
Acyl Ghrelin [extracellular region] (Homo sapiens)
Other forms of this molecule
O-octanoyl-L-serine-GHRL-1(24-50) [extracellular region]
DecS-GHRL-1(24-50) [extracellular region]
O-octanoyl-L-serine-GHRL-1(24-51) [extracellular region]
GHRL-1(52-117) [secretory granule lumen]
O-octanoyl-L-serine-GHRL-1(24-50) [secretory granule lumen]
O-octanoyl-L-serine-GHRL-1(24-51) [secretory granule lumen]
DecS-GHRL-1(24-50) [secretory granule lumen]
DecS-GHRL-1(24-51) [secretory granule lumen]
GHRL-1(52-117) [extracellular region]
O-octanoyl-L-serine-GHRL-1(24-117) [secretory granule lumen]
DecS-GHRL-1(24-117) [secretory granule lumen]
GHRL-1(24-117) [endoplasmic reticulum lumen]
DecS-GHRL-1(24-117) [endoplasmic reticulum lumen]
GHRL-1 [endoplasmic reticulum lumen]
O-octanoyl-L-serine-GHRL-1(24-117) [endoplasmic reticulum lumen]
GHRL-1(24-50) [extracellular region]
GHRL-1(24-51) [extracellular region]
Inferred To
ghrl [extracellular region]
(Danio rerio)
Homologues of DecS-GHRL-1(24-51) [extracellular region]
(Sus scrofa)
Ghrl [extracellular region]
(Mus musculus)
Ghrl [extracellular region]
(Rattus norvegicus)
GHRL [extracellular region]
(Bos taurus)
GHRL [extracellular region]
(Canis familiaris)
GHRL [extracellular region]
(Sus scrofa)
ghr [extracellular region]
(Gallus gallus)
Modified Residues
Name
O-decanoyl-L-serine at 26
Coordinate
26
PsiMod Name
O-decanoyl-L-serine [MOD:00390]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-decanoyl-L-serine.
Cross References
RefSeq
NP_001128413.1
,
NP_057446.1
,
XP_016862102.1
,
NP_001289752.1
,
NP_001289753.1
,
NP_001128417.1
,
XP_016862101.1
,
NP_001128418.1
,
NP_001289754.1
,
NP_001128416.1
,
NP_001289751.1
,
NP_001289750.1
ZINC - Investigational
GHRL_HUMAN
ENSEMBL
ENST00000287656
,
ENSP00000414819
,
ENST00000429122
,
ENST00000437422
,
ENST00000430179
,
ENSP00000403725
,
ENSP00000405464
,
ENST00000335542
,
ENST00000422159
,
ENSP00000391406
,
ENSP00000335074
,
ENSP00000388145
,
ENST00000449238
,
ENST00000439975
,
ENST00000457360
,
ENSP00000399922
,
ENSP00000287656
,
ENSP00000416768
,
ENSG00000157017
OpenTargets
ENSG00000157017
GeneCards
GHRL
ZINC - Substances
GHRL_HUMAN
HPA
ENSG00000157017-GHRL
ZINC target
Q9UBU3
PRO
Q9UBU3
Pharos - Targets
Q9UBU3
ZINC - Predictions - Purchasable
GHRL_HUMAN
PDB
7F9Y
,
7NA7
,
7W2Z
,
6H3E
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