Reactome | PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin

PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin

Stable Identifier

R-HSA-422021

Type

Reaction [transition]

Species

Homo sapiens

Compartment

secretory granule lumen

ReviewStatus

5/5

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PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin

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Acyl proghrelin is cleaved by prohormone convertase 1/3 (PC1/3) to yield acyl ghrelin (the N-terminal fragment) and C-ghrelin (the C-terminal fragment). Transfection experiments show that PC1/3 is sufficient to generate acyl ghrelin of 28 amino acid residues (acyl ghrelin-28). Acyl ghrelin of 27 amino acid residues (acyl ghrelin-27) can also be detected in plasma. How acyl ghrelin-27 is generated remains undetermined but it is speculated to derive from the cleavage of arginine-28 from the C-terminus of ghrelin by a carboxypeptidase B-like enzyme.

Literature References

PubMed ID	Title	Journal	Year
19280057	Ghrelin fluctuation, what determines its production? Yin, X, Li, Y, Xu, G, An, W, Zhang, W	Acta Biochim Biophys Sin (Shanghai)	2009
18396350	Ghrelin, des-acyl ghrelin and obestatin: three pieces of the same puzzle Soares, JB, Leite-Moreira, AF	Peptides	2008
19628676	Production of n-octanoyl-modified ghrelin in cultured cells requires prohormone processing protease and ghrelin O-acyltransferase, as well as n-octanoic acid Takahashi, T, Ida, T, Sato, T, Nakashima, Y, Nakamura, Y, Tsuji, A, Kojima, M	J Biochem	2009