PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin

Stable Identifier
R-HSA-422021
Type
Reaction
Species
Homo sapiens
Compartment
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Acyl proghrelin is cleaved by prohormone convertase 1/3 (PC1/3) to yield acyl ghrelin (the N-terminal fragment) and C-ghrelin (the C-terminal fragment). Transfection experiments show that PC1/3 is sufficient to generate acyl ghrelin of 28 amino acid residues (acyl ghrelin-28). Acyl ghrelin of 27 amino acid residues (acyl ghrelin-27) can also be detected in plasma. How acyl ghrelin-27 is generated remains undetermined but it is speculated to derive from the cleavage of arginine-28 from the C-terminus of ghrelin by a carboxypeptidase B-like enzyme.

Literature References
PubMed ID Title Journal Year
19280057 Ghrelin fluctuation, what determines its production?

Yin, X, Li, Y, Zhang, W, An, W, Xu, G

Acta Biochim Biophys Sin (Shanghai) 2009
18396350 Ghrelin, des-acyl ghrelin and obestatin: three pieces of the same puzzle

Soares, JB, Leite-Moreira, AF

Peptides 2008
19628676 Production of n-octanoyl-modified ghrelin in cultured cells requires prohormone processing protease and ghrelin O-acyltransferase, as well as n-octanoic acid

Nakamura, Y, Ida, T, Tsuji, A, Sato, T, Takahashi, T, Nakashima, Y, Kojima, M

J Biochem 2009
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Catalyst Activity

serine-type endopeptidase activity of PC1:calcium cofactor [secretory granule lumen]

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