Ghrelin O-acyltransferase decanoylates Proghrelin

Stable Identifier
Reaction [transition]
Homo sapiens
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Proghrelin is decanoylated by ghrelin O-acyltransferase (GOAT/MBOAT4), an enzyme present in the endoplasmic reticulum membrane which both transports the decanoic acid substrate and condenses it on the hydroxyl group of serine-3 of the mature protein. The most common acylated form of ghrelin is octanoyl ghrelin but decanoyl ghrelin is also detected in plasma. GOAT is able to use substrates up to tetradecanoic acid. Ghrelin is the only protein known to undergo such a modification.

Literature References
PubMed ID Title Journal Year
18396350 Ghrelin, des-acyl ghrelin and obestatin: three pieces of the same puzzle

Soares, JB, Leite-Moreira, AF

Peptides 2008
19280057 Ghrelin fluctuation, what determines its production?

Yin, X, Li, Y, Xu, G, An, W, Zhang, W

Acta Biochim Biophys Sin (Shanghai) 2009
12414809 Structural divergence of human ghrelin. Identification of multiple ghrelin-derived molecules produced by post-translational processing

Hosoda, H, Kojima, M, Mizushima, T, Shimizu, S, Kangawa, K

J Biol Chem 2003
19628676 Production of n-octanoyl-modified ghrelin in cultured cells requires prohormone processing protease and ghrelin O-acyltransferase, as well as n-octanoic acid

Takahashi, T, Ida, T, Sato, T, Nakashima, Y, Nakamura, Y, Tsuji, A, Kojima, M

J Biochem 2009
18443287 Ghrelin octanoylation mediated by an orphan lipid transferase

Gutierrez, JA, Solenberg, PJ, Perkins, DR, Willency, JA, Knierman, MD, Jin, Z, Witcher, DR, Luo, S, Onyia, JE, Hale, JE

Proc Natl Acad Sci U S A 2008
Participant Of
Catalyst Activity
Catalyst Activity
O-acyltransferase activity of MBOAT4 [endoplasmic reticulum membrane]
Physical Entity
Orthologous Events
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