Reactome | MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha)

MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha)

Stable Identifier

R-HSA-420818

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi membrane, cytosol

ReviewStatus

5/5

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Once in the Golgi, ATF6-alpha undergoes two sequential proteolytic cleavages. S2P catalyzes the second of these, cleaving the ATF6-alpha S1P cleavage product within its transmembrane domain. This cleavage liberates a 50 kD N-terminal fragment with bZIP transcription factor activity into the cytosol.

Literature References

PubMed ID	Title	Journal	Year
10564271	Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress Haze, K, Yoshida, H, Yanagi, H, Yura, T, Mori, K	Mol Biol Cell	1999
15299016	Dependence of site-2 protease cleavage of ATF6 on prior site-1 protease digestion is determined by the size of the luminal domain of ATF6 Shen, J, Prywes, R	J Biol Chem	2004
11163209	ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs Ye, J, Rawson, RB, Komuro, R, Chen, X, Davé, UP, Prywes, R, Brown, MS, Goldstein, JL	Mol Cell	2000