MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha)

Stable Identifier
Reaction [transition]
Homo sapiens
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Once in the Golgi, ATF6-alpha undergoes two sequential proteolytic cleavages. S2P catalyzes the second of these, cleaving the ATF6-alpha S1P cleavage product within its transmembrane domain. This cleavage liberates a 50 kD N-terminal fragment with bZIP transcription factor activity into the cytosol.

Literature References
PubMed ID Title Journal Year
10564271 Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress

Mori, K, Yoshida, H, Yanagi, H, Haze, K, Yura, T

Mol Biol Cell 1999
15299016 Dependence of site-2 protease cleavage of ATF6 on prior site-1 protease digestion is determined by the size of the luminal domain of ATF6

Shen, J, Prywes, R

J Biol Chem 2004
11163209 ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs

Brown, MS, Chen, X, Rawson, RB, Komuro, R, Goldstein, JL, Davé, UP, Ye, J, Prywes, R

Mol Cell 2000
Catalyst Activity

metalloendopeptidase activity of MBTPS2 [Golgi membrane]

Orthologous Events
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