MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha)

Stable Identifier
R-HSA-420818
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Once in the Golgi, ATF6-alpha undergoes two sequential proteolytic cleavages. S2P catalyzes the second of these, cleaving the ATF6-alpha S1P cleavage product within its transmembrane domain. This cleavage liberates a 50 kD N-terminal fragment with bZIP transcription factor activity into the cytosol.

Literature References
PubMed ID Title Journal Year
15299016 Dependence of site-2 protease cleavage of ATF6 on prior site-1 protease digestion is determined by the size of the luminal domain of ATF6

Shen, J, Prywes, R

J Biol Chem 2004
10564271 Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress

Haze, K, Yoshida, H, Yanagi, H, Yura, T, Mori, K

Mol Biol Cell 1999
11163209 ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs

Ye, J, Rawson, RB, Komuro, R, Chen, X, Davé, UP, Prywes, R, Brown, MS, Goldstein, JL

Mol Cell 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
metalloendopeptidase activity of MBTPS2 [Golgi membrane]
Physical Entity
Activity
Orthologous Events
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