GABAB heterodimeric receptor binds GABA

Stable Identifier
Homo sapiens
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Gamma-aminobutyric acid (GABA) is the chief inhibitory neurotransmitter in the mammalian central nervous system. GABA exerts its effects through two ligand-gated channels and a the GPCR GABAB (Kaupmann K et al, 1998), which acts through G proteins to regulate potassium and calcium channels. GABAB can only bind GABA once it forms a heterodimer composed of the GABABR1 and GABABR2 receptors (White JH et al, 1998). The effects of this dimer are mediated by coupling to the G protein alpha i subunit, which inhibits adenylyl cyclase (Odagaki & Koyama 2001).

Literature References
PubMed ID Title Journal Year
9872316 Heterodimerization is required for the formation of a functional GABA(B) receptor

White, JH, Marshall, FH, Emson, P, Fraser, NJ, Foord, SM, Main, MJ, Wise, A, Disney, GH, Barnes, AA, Green, A

Nature 1998
9844003 Human gamma-aminobutyric acid type B receptors are differentially expressed and regulate inwardly rectifying K+ channels

Froestl, W, Bettler, B, Karschin, A, Kaupmann, K, Pfaff, T, Heid, J, Mosbacher, J, Schuler, V, Bittiger, H, Leonhard, S, Bischoff, S

Proc Natl Acad Sci U S A 1998
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