The nectin-like (Necl) family comprises five members, called Necl-1 to -5. Necl have an overall organization like that of nectins with three Ig-like domains, a transmembrane region and a cytoplasmic domain. Necls have a greater variety of functions than nectins and are ubiquitously expressed. In contrast to nectins, Necls do not interact with afadin. Transhomodimerization has been described for Necl-1, -2 and -3 but not for Necl-4 and -5. (Sakisaka et al., 2007; Sakisaka and Takai, 2004; Takai et al., 2008).
Murakami, Y, Fukuhara, H, Yageta, M, Masuda, M, Maruyama, T, Kuramochi, M, Nomoto, A
Gerber, A, Pellissier, F, Ossipow, V, Ballivet, M, Bauer, C
Yuan, J, Dong, X, Chen, T, Rao, Z, Peng, X, Lin, P, Gao, J, Peng, Y, Xu, F, Qiang, B, Gong, Y
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