Transhomodimerization of Nectin-like (Necl) proteins

Stable Identifier
Reaction [binding]
Homo sapiens
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The nectin-like (Necl) family comprises five members, called Necl-1 to -5. Necl have an overall organization like that of nectins with three Ig-like domains, a transmembrane region and a cytoplasmic domain. Necls have a greater variety of functions than nectins and are ubiquitously expressed. In contrast to nectins, Necls do not interact with afadin. Transhomodimerization has been described for Necl-1, -2 and -3 but not for Necl-4 and -5. (Sakisaka et al., 2007; Sakisaka and Takai, 2004; Takai et al., 2008).

Literature References
PubMed ID Title Journal Year
17967169 The adhesion molecule Necl-3/SynCAM-2 localizes to myelinated axons, binds to oligodendrocytes and promotes cell adhesion

Pellissier, F, Gerber, A, Bauer, C, Ballivet, M, Ossipow, V

BMC Neurosci 2007
12050160 The tumor suppressor protein TSLC1 is involved in cell-cell adhesion

Masuda, M, Yageta, M, Fukuhara, H, Kuramochi, M, Maruyama, T, Nomoto, A, Murakami, Y

J Biol Chem 2002
16467305 Crystal structure of the V domain of human Nectin-like molecule-1/Syncam3/Tsll1/Igsf4b, a neural tissue-specific immunoglobulin-like cell-cell adhesion molecule

Dong, X, Xu, F, Gong, Y, Gao, J, Lin, P, Chen, T, Peng, Y, Qiang, B, Yuan, J, Peng, X, Rao, Z

J Biol Chem 2006
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