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GRM4 [plasma membrane]
Stable Identifier
R-HSA-420528
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Metabotropic glutamate receptor 4, GRM4_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
Group II and III metabotropic gutamate receptors:Glu [plasma membrane] (Homo sapiens)
GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Homo sapiens)
GRM4 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
Group II and III metabotropic gutamate receptors:Glu [plasma membrane] (Homo sapiens)
GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Homo sapiens)
GRM4 [plasma membrane] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
Group II and III metabotropic gutamate receptors:Glu [plasma membrane] (Homo sapiens)
GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Homo sapiens)
GRM4 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
Group II and III metabotropic gutamate receptors:Glu [plasma membrane] (Homo sapiens)
GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Homo sapiens)
GRM4 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
Group II and III metabotropic gutamate receptors:Glu [plasma membrane] (Homo sapiens)
GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Homo sapiens)
GRM4 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
Group II and III metabotropic gutamate receptors:Glu [plasma membrane] (Homo sapiens)
GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Homo sapiens)
GRM4 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class C/3 (Metabotropic glutamate/pheromone receptors) (Homo sapiens)
Metabotropic glutamate receptors bind glutamate (Homo sapiens)
GRM1-8 [plasma membrane] (Homo sapiens)
GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Homo sapiens)
GRM4 [plasma membrane] (Homo sapiens)
GRM1-8:L-Glu [plasma membrane] (Homo sapiens)
GRM1-8 [plasma membrane] (Homo sapiens)
GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Homo sapiens)
GRM4 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q14833 GRM4
Gene Names
GRM4, GPRC1D, MGLUR4
Chain
signal peptide:1-32, chain:33-912
Reference Genes
BioGPS Gene:2914 GRM4
COSMIC (genes):GRM4 GRM4
CTD Gene:2914 GRM4
dbSNP Gene:2914 GRM4
ENSEMBL:ENSG00000124493 GRM4
ENSEMBL_homo_sapiens_GENE:ENSG00000124493.14 GRM4
HGNC:4596 GRM4
KEGG Gene (Homo sapiens):2914 GRM4
Monarch:2914 GRM4
NCBI Gene:2914 GRM4
OMIM:604100 GRM4
UCSC:Q14833 GRM4
Reference Transcript
RefSeq:XM_017010793.1 GRM4
RefSeq:NM_001256812.2 GRM4
RefSeq:NM_000841.3 GRM4
RefSeq:NM_001256809.2 GRM4
RefSeq:NM_001256813.2 GRM4
RefSeq:XM_017010790.1 GRM4
RefSeq:XM_017010791.1 GRM4
RefSeq:NM_001256811.2 GRM4
RefSeq:NM_001282847.1 GRM4
Other Identifiers
11750311_a_at
11750713_a_at
11754969_x_at
17018347
210234_PM_at
210234_at
2914
2950967
2950969
2950971
2950972
2950973
2950974
2950984
2950985
2950987
2950988
2950989
2950990
2950994
2950997
2951001
2951010
2951011
2951012
2951019
2951020
2951021
2951022
2951037
2951038
2951039
2951040
35485_at
8125805
A_23_P70588
A_33_P3282390
GE60065
GO:0001640
GO:0004930
GO:0005886
GO:0007165
GO:0007186
GO:0007196
GO:0007216
GO:0007268
GO:0007269
GO:0008066
GO:0012501
GO:0016020
GO:0023052
GO:0031410
GO:0043226
GO:0043410
GO:0043523
GO:0045202
GO:0051966
GO:0060089
GO:0098793
HMNXSV003047371
ILMN_1752843
ILMN_1906410
ILMN_1916760
PH_hs_0025198
TC06001650.hg
U92457_s_at
X80818_at
g1935038_3p_at
Participates
as a member of
GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Homo sapiens)
Other forms of this molecule
GRM4(309-912) [plasma membrane]
Inferred To
GRM4 [plasma membrane]
(Bos taurus)
GRM4 [plasma membrane]
(Canis familiaris)
GRM4 [plasma membrane]
(Gallus gallus)
GRM4 [plasma membrane]
(Mus musculus)
GRM4 [plasma membrane]
(Rattus norvegicus)
GRM4 [plasma membrane]
(Sus scrofa)
mgl-3 [plasma membrane]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_001243742.1
,
NP_000832.1
,
NP_001269776.1
,
NP_001243738.1
,
XP_016866280.1
,
XP_016866282.1
,
NP_001243740.1
,
XP_016866279.1
,
NP_001243741.1
ZINC - World Drugs
GRM4_HUMAN
Guide to Pharmacology - Targets
292
OpenTargets
ENSG00000124493
ZINC - FDA approved
GRM4_HUMAN
ZINC - Substances
GRM4_HUMAN
ZINC target
Q14833
ZINC - Biogenic
GRM4_HUMAN
PRO
Q14833
PDB
8JD5
,
7E9H
,
8JD6
,
8JD4
ZINC - Metabolites
GRM4_HUMAN
HPA
ENSG00000124493-GRM4
GeneCards
Q14833
Ensembl
ENSP00000437730
,
ENSP00000398456
,
ENST00000455714
,
ENST00000535756
,
ENSP00000477466
,
ENST00000544773
,
ENST00000609222
,
ENST00000374177
,
ENSP00000440556
,
ENSG00000124493
,
ENSP00000437925
,
ENST00000538487
,
ENSP00000363292
Pharos - Targets
Q14833
ZINC - Predictions - Purchasable
GRM4_HUMAN
HMDB Protein
HMDBP10861
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