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PTH [extracellular region]
Stable Identifier
R-HSA-420445
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Parathyroid hormone, PTHY_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (s) signalling events (Homo sapiens)
Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
PTH1R,PTH2R:PTH1R,PTH2R ligands [plasma membrane] (Homo sapiens)
PTH1R,PTH2R ligands [extracellular region] (Homo sapiens)
PTH [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
PTH1R,PTH2R:PTH1R,PTH2R ligands [plasma membrane] (Homo sapiens)
PTH1R,PTH2R ligands [extracellular region] (Homo sapiens)
PTH [extracellular region] (Homo sapiens)
Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
PTH1R,PTH2R:PTH1R,PTH2R ligands [plasma membrane] (Homo sapiens)
PTH1R,PTH2R ligands [extracellular region] (Homo sapiens)
PTH [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
PTH1R,PTH2R:PTH1R,PTH2R ligands [plasma membrane] (Homo sapiens)
PTH1R,PTH2R ligands [extracellular region] (Homo sapiens)
PTH [extracellular region] (Homo sapiens)
The Ligand:GPCR:Gs complex dissociates (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
PTH1R,PTH2R:PTH1R,PTH2R ligands [plasma membrane] (Homo sapiens)
PTH1R,PTH2R ligands [extracellular region] (Homo sapiens)
PTH [extracellular region] (Homo sapiens)
Ligands of GPCRs that activate Gs [extracellular region] (Homo sapiens)
PTH1R,PTH2R ligands [extracellular region] (Homo sapiens)
PTH [extracellular region] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class B/2 (Secretin family receptors) (Homo sapiens)
Parathyroid hormone receptor can bind parathyroid hormone (Homo sapiens)
PTH1R,PTH2R ligands [extracellular region] (Homo sapiens)
PTH [extracellular region] (Homo sapiens)
PTH1R,PTH2R:PTH1R,PTH2R ligands [plasma membrane] (Homo sapiens)
PTH1R,PTH2R ligands [extracellular region] (Homo sapiens)
PTH [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P01270 PTH
Gene Names
PTH
Chain
signal peptide:1-25, propeptide:26-31, chain:32-115
Reference Genes
BioGPS Gene:5741 PTH
COSMIC (genes):PTH PTH
CTD Gene:5741 PTH
dbSNP Gene:5741 PTH
ENSEMBL:ENSG00000152266 PTH
HGNC:9606 PTH
KEGG:hsa:5741 PTH
Monarch:5741 PTH
NCBI Gene:5741 PTH
OMIM:168450 PTH
UCSC:P01270 PTH
Reference Transcript
RefSeq:NM_000315.3 PTH
Other Identifiers
11719358_at
16735970
206977_PM_at
206977_at
3363687
3363688
3363689
3363690
3363692
3363694
34399_at
5741
708_at
7946687
A_23_P24835
GE532902
GO:0001501
GO:0005179
GO:0005515
GO:0005576
GO:0005615
GO:0006351
GO:0006355
GO:0006366
GO:0006874
GO:0007165
GO:0007186
GO:0007189
GO:0007266
GO:0007267
GO:0008628
GO:0009059
GO:0009410
GO:0009967
GO:0010288
GO:0010468
GO:0010628
GO:0010629
GO:0010960
GO:0023052
GO:0030282
GO:0030501
GO:0031667
GO:0031856
GO:0031857
GO:0032331
GO:0033280
GO:0045453
GO:0045471
GO:0045725
GO:0045778
GO:0045944
GO:0046058
GO:0046326
GO:0046686
GO:0048018
GO:0048856
GO:0048873
GO:0051428
GO:0055062
GO:0055074
GO:0055086
GO:0060732
GO:0071107
GO:0071774
GO:0071864
GO:0071866
GO:0090290
GO:0098772
GO:1900158
GO:1901135
HMNXSV003043927
ILMN_1781669
ILMN_2202048
J00301_at
PH_hs_0002931
TC11001435.hg
g4506266_3p_at
Participates
as a member of
PTH1R,PTH2R ligands [extracellular region] (Homo sapiens)
Inferred To
Pth [extracellular region]
(Mus musculus)
Pth [extracellular region]
(Rattus norvegicus)
pth1a [extracellular region]
(Danio rerio)
PTH [extracellular region]
(Bos taurus)
PTH [extracellular region]
(Canis familiaris)
PTH [extracellular region]
(Gallus gallus)
PTH [extracellular region]
(Sus scrofa)
Cross References
RefSeq
NP_000306.1
OpenTargets
ENSG00000152266
ENSEMBL
ENST00000529816
,
ENSP00000282091
,
ENSP00000433208
,
ENST00000282091
HPA
ENSG00000152266-PTH
PRO
P01270
Pharos - Targets
P01270
Orphanet
PTH
PDB
1HPH
,
1FVY
,
1ZWG
,
1HTH
,
7VVM
,
8T5F
,
7VVK
,
7VVN
,
8HAO
,
1ZWF
,
7VVL
,
8HA0
,
2L1X
,
1HPY
,
7VVO
,
7Y36
,
8FLQ
,
1BWX
,
1ZWA
,
1ZWD
,
1ZWE
,
1ZWB
,
3C4M
,
1ET1
HMDB Protein
HMDBP02068
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