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PTHLH [extracellular region]
Stable Identifier
R-HSA-420444
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Parathyroid hormone-related protein, PTHR_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (s) signalling events (Homo sapiens)
Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
PTH1R,PTH2R:PTH1R,PTH2R ligands [plasma membrane] (Homo sapiens)
PTH1R,PTH2R ligands [extracellular region] (Homo sapiens)
PTHLH [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
PTH1R,PTH2R:PTH1R,PTH2R ligands [plasma membrane] (Homo sapiens)
PTH1R,PTH2R ligands [extracellular region] (Homo sapiens)
PTHLH [extracellular region] (Homo sapiens)
Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
PTH1R,PTH2R:PTH1R,PTH2R ligands [plasma membrane] (Homo sapiens)
PTH1R,PTH2R ligands [extracellular region] (Homo sapiens)
PTHLH [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
PTH1R,PTH2R:PTH1R,PTH2R ligands [plasma membrane] (Homo sapiens)
PTH1R,PTH2R ligands [extracellular region] (Homo sapiens)
PTHLH [extracellular region] (Homo sapiens)
The Ligand:GPCR:Gs complex dissociates (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
PTH1R,PTH2R:PTH1R,PTH2R ligands [plasma membrane] (Homo sapiens)
PTH1R,PTH2R ligands [extracellular region] (Homo sapiens)
PTHLH [extracellular region] (Homo sapiens)
Ligands of GPCRs that activate Gs [extracellular region] (Homo sapiens)
PTH1R,PTH2R ligands [extracellular region] (Homo sapiens)
PTHLH [extracellular region] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class B/2 (Secretin family receptors) (Homo sapiens)
Parathyroid hormone receptor can bind parathyroid hormone (Homo sapiens)
PTH1R,PTH2R ligands [extracellular region] (Homo sapiens)
PTHLH [extracellular region] (Homo sapiens)
PTH1R,PTH2R:PTH1R,PTH2R ligands [plasma membrane] (Homo sapiens)
PTH1R,PTH2R ligands [extracellular region] (Homo sapiens)
PTHLH [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P12272 PTHLH
Gene Names
PTHLH, PTHRP
Chain
signal peptide:1-24, propeptide:25-34, chain:37-177, peptide:37-72, peptide:74-130, peptide:143-175
Reference Genes
BioGPS Gene:5744 PTHLH
COSMIC (genes):PTHLH PTHLH
CTD Gene:5744 PTHLH
dbSNP Gene:5744 PTHLH
ENSEMBL:ENSG00000087494 PTHLH
ENSEMBL_homo_sapiens_GENE:ENSG00000087494.16 PTHLH
HGNC:9607 PTHLH
KEGG Gene (Homo sapiens):5744 PTHLH
Monarch:5744 PTHLH
NCBI Gene:5744 PTHLH
OMIM:168470 PTHLH
UCSC:P12272 PTHLH
Reference Transcript
RefSeq:NM_002820.2 PTHLH
RefSeq:XM_017019674.1 PTHLH
RefSeq:NM_198965.1 PTHLH
RefSeq:XM_011520774.2 PTHLH
RefSeq:XM_011520775.2 PTHLH
RefSeq:NM_198964.1 PTHLH
RefSeq:NM_198966.1 PTHLH
RefSeq:XM_017019675.1 PTHLH
Other Identifiers
11731897_a_at
11731983_a_at
11740245_a_at
1556773_PM_at
1556773_at
16762661
206300_PM_s_at
206300_s_at
210355_PM_at
210355_at
211756_PM_at
211756_at
3448745
3448746
3448749
3448750
3448751
3448752
3448753
3448754
3448758
3448759
3448760
3448761
3448762
3448763
3448764
3448765
3448766
3448769
3448770
37989_at
5744
615_s_at
7962000
A_23_P2271
A_24_P17031
A_24_P923612
GE81198
GO:0001501
GO:0002076
GO:0005179
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005737
GO:0005794
GO:0005829
GO:0007165
GO:0007189
GO:0007267
GO:0007565
GO:0008284
GO:0008285
GO:0008544
GO:0010468
GO:0022414
GO:0023052
GO:0030154
GO:0030282
GO:0032330
GO:0032331
GO:0043226
GO:0046058
GO:0048018
GO:0048856
GO:0051428
GO:0055086
GO:0061182
GO:0098772
GO:1901135
HMNXSV003016233
Hs2.385300.1.A1_3p_at
ILMN_1785699
ILMN_2314169
M17183_s_at
M24349_s_at
M24351_cds2_at
M24351_cds3_s_at
M26958_s_at
M57293_at
PH_hs_0005005
PH_hs_0031398
TC12001341.hg
TC12002810.hg
g13543620_3p_at
g190705_3p_at
g190705_3p_x_at
g4506268_3p_s_at
Participates
as a member of
PTH1R,PTH2R ligands [extracellular region] (Homo sapiens)
Inferred To
PTHLH [extracellular region]
(Bos taurus)
PTHLH [extracellular region]
(Canis familiaris)
PTHLH [extracellular region]
(Gallus gallus)
PTHLH [extracellular region]
(Sus scrofa)
pthrp [extracellular region]
(Danio rerio)
Pthlh [extracellular region]
(Mus musculus)
Pthlh [extracellular region]
(Rattus norvegicus)
pthlh [extracellular region]
(Xenopus tropicalis)
Cross References
RefSeq
XP_011519077.1
,
XP_016875164.1
,
NP_002811.1
,
NP_945317.1
,
NP_945315.1
,
NP_945316.1
,
XP_016875163.1
,
XP_011519076.1
OpenTargets
ENSG00000087494
HPA
ENSG00000087494-PTHLH
GeneCards
P12272
Ensembl
ENST00000201015
,
ENST00000545234
,
ENST00000539239
,
ENSP00000440613
,
ENSG00000087494
,
ENST00000535992
,
ENST00000395868
,
ENSP00000441765
,
ENSP00000201015
,
ENST00000538310
,
ENSP00000441890
,
ENSP00000379209
,
ENST00000395872
,
ENSP00000379213
,
ENSP00000441571
PRO
P12272
Pharos - Targets
P12272
Orphanet
19039
HMDB Protein
HMDBP02119
PDB
7VVJ
,
7UZP
,
3FFD
,
8FLR
,
1M5N
,
1BZG
,
8D52
,
8D51
,
8HAF
,
7UZO
,
3H3G
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