AMY1-3 bind IAPP(34-70)

Stable Identifier
R-HSA-420265
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Amylin receptors can bind Amylin
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Amylin (islet amyloid polypeptide, diabetes associated peptide) is a 37 amino acid peptide first purified from amyloid deposits in the pancreatic islets of type 2 diabetic patients (Nishi M et al, 1989). It is a product of the islet B-cell, along with insulin and probably has a hormonal role in the regulation of nutrient intake. Amylin receptors are multimeric complexes, formed by CT receptor (Gorn AH et al, 1992) interaction with receptor activity modifying proteins (RAMPs) (McLatchie LM et al, 1998). The CT receptor interacts with the three RAMPs, generating multiple subtypes of amylin receptor (AMY1-3).

Literature References
PubMed ID Title Journal Year
9620797 RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor

Lee, MG, Solari, R, Fraser, NJ, McLatchie, LM, Foord, SM, Wise, A, Main, MJ, Thompson, N, Brown, J

Nature 1998
1331173 Cloning, characterization, and expression of a human calcitonin receptor from an ovarian carcinoma cell line

Yamin, M, Lodish, HF, Flannery, MR, Auron, PE, Tapp, DR, Gorn, AH, Manning, CA, Goldring, SR, Krane, SM, Lin, HY

J Clin Invest 1992
2608057 Human islet amyloid polypeptide gene: complete nucleotide sequence, chromosomal localization, and evolutionary history

Byers, MG, Nishi, M, Steiner, DF, Bell, GI, Eddy, RL, Seino, S, Fan, YS, Shows, TB, Sanke, T

Mol Endocrinol 1989
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