GHRH receptor binds GHRH

Stable Identifier
R-HSA-420243
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
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GHRH receptor binds GHRH
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Growth hormone-releasing hormone (GHRH, somatocrinin, growth hormone-releasing factor) (Gubler U et al, 1983) is released from neurosecretory cells in the hypothalamus and along with the inhibitory peptide, somatostatin, mediates the neuroendocrine regulation of pituitary growth hormone synthesis and secretion. The GHRH receptor (Gaylinn BD et al, 1993) is expressed in the pituitary gland and mediates the activity of GHRH. Downstream signalling is mediated by coupling to the G protein alpha s subunit, which stimulates adenylyl cyclase which increases intracellular cAMP levels (Mayo KE, 1992).

Literature References
PubMed ID Title Journal Year
1333056 Molecular cloning and expression of a pituitary-specific receptor for growth hormone-releasing hormone

Mayo, KE

Mol Endocrinol 1992
7680413 Molecular cloning and expression of a human anterior pituitary receptor for growth hormone-releasing hormone

Gaylinn, BD, Harrison, JK, Zysk, JR, Lyons, CE, Lynch, KR, Thorner, MO

Mol Endocrinol 1993
6192430 Cloning and sequence analysis of cDNA for the precursor of human growth hormone-releasing factor, somatocrinin

Gubler, U, Monahan, JJ, Lomedico, PT, Bhatt, RS, Collier, KJ, Hoffman, BJ, Bohlen, P, Esch, F, Ling, N, Zeytin, F, Brazeau, P, Poonian, MS, Gage, LP

Proc Natl Acad Sci U S A 1983
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Authored
Jassal, B  (2009-05-11)
Reviewed
D'Eustachio, P  (2009-05-29)
Created
Jassal, B  (2009-05-11)