Intermedin (AM2) (Roh J et al, 2004) and adrenomedullin (AM) (Kitamura K et al, 1993) belong to the calcitonin peptide hormone family and are important for cardiovascular and respiratory regulation. The functional adrenomedullin receptor AM1 is composed of the calcitonin gene-related peptide receptor (CGPR) and receptor activity modifying protein 2 (RAMP2) (Kamitani S et al, 1999). AM1 receptor can bind either of these peptide hormones and its activity is mediated by coupling with the G protein alpha s subunit which stimulates adenylyl cyclase and increases intracellular cAMP levels (Aiyar N et al, 2001). The function of the AM2 receptor (formed by the combination of CGPR and RAMP3) is very similar to that of AM1.
Lee, MG, Solari, R, Fraser, NJ, McLatchie, LM, Foord, SM, Wise, A, Main, MJ, Thompson, N, Brown, J
Kuwasako, K, Kamitani, S, Nakahara, K, Shimekake, Y, Sakata, T, Asakawa, M
Chang, CL, Roh, J, Bhalla, A, Hsu, SY, Klein, C
Pullen, M, Nambi, P, Disa, J, Aiyar, N
Eto, T, Kitamura, K, Kangawa, K, Kawamoto, M, Matsuo, H, Ichiki, Y, Nakamura, S
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