The adrenomedullin receptor can bind adrenomedullin and intermedin

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Intermedin (AM2) (Roh J et al, 2004) and adrenomedullin (AM) (Kitamura K et al, 1993) belong to the calcitonin peptide hormone family and are important for cardiovascular and respiratory regulation. The functional adrenomedullin receptor AM1 is composed of the calcitonin gene-related peptide receptor (CGPR) and receptor activity modifying protein 2 (RAMP2) (Kamitani S et al, 1999). AM1 receptor can bind either of these peptide hormones and its activity is mediated by coupling with the G protein alpha s subunit which stimulates adenylyl cyclase and increases intracellular cAMP levels (Aiyar N et al, 2001). The function of the AM2 receptor (formed by the combination of CGPR and RAMP3) is very similar to that of AM1.

Literature References
PubMed ID Title Journal Year
9620797 RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor

Lee, MG, Solari, R, Fraser, NJ, McLatchie, LM, Foord, SM, Wise, A, Main, MJ, Thompson, N, Brown, J

Nature 1998
10217420 The RAMP2/CRLR complex is a functional adrenomedullin receptor in human endothelial and vascular smooth muscle cells

Kuwasako, K, Kamitani, S, Nakahara, K, Shimekake, Y, Sakata, T, Asakawa, M

FEBS Lett 1999
14615490 Intermedin is a calcitonin/calcitonin gene-related peptide family peptide acting through the calcitonin receptor-like receptor/receptor activity-modifying protein receptor complexes

Chang, CL, Roh, J, Bhalla, A, Hsu, SY, Klein, C

J Biol Chem 2004
11693189 Receptor activity modifying proteins interaction with human and porcine calcitonin receptor-like receptor (CRLR) in HEK-293 cells

Pullen, M, Nambi, P, Disa, J, Aiyar, N

Mol Cell Biochem 2001
8387282 Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma

Eto, T, Kitamura, K, Kangawa, K, Kawamoto, M, Matsuo, H, Ichiki, Y, Nakamura, S

Biochem Biophys Res Commun 1993
Orthologous Events
Cite Us!