Reactome | The adrenomedullin receptor can bind adrenomedullin and intermedin

The adrenomedullin receptor can bind adrenomedullin and intermedin

Stable Identifier

R-HSA-420214

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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The adrenomedullin receptor can bind adrenomedullin and intermedin

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Intermedin (AM2) (Roh J et al, 2004) and adrenomedullin (AM) (Kitamura K et al, 1993) belong to the calcitonin peptide hormone family and are important for cardiovascular and respiratory regulation. The functional adrenomedullin receptor AM1 is composed of the calcitonin gene-related peptide receptor (CGPR) and receptor activity modifying protein 2 (RAMP2) (Kamitani S et al, 1999). AM1 receptor can bind either of these peptide hormones and its activity is mediated by coupling with the G protein alpha s subunit which stimulates adenylyl cyclase and increases intracellular cAMP levels (Aiyar N et al, 2001). The function of the AM2 receptor (formed by the combination of CGPR and RAMP3) is very similar to that of AM1.

Literature References

PubMed ID	Title	Journal	Year
9620797	RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor McLatchie, LM, Fraser, NJ, Main, MJ, Wise, A, Brown, J, Thompson, N, Solari, R, Lee, MG, Foord, SM	Nature	1998
10217420	The RAMP2/CRLR complex is a functional adrenomedullin receptor in human endothelial and vascular smooth muscle cells Kamitani, S, Asakawa, M, Shimekake, Y, Kuwasako, K, Nakahara, K, Sakata, T	FEBS Lett	1999
14615490	Intermedin is a calcitonin/calcitonin gene-related peptide family peptide acting through the calcitonin receptor-like receptor/receptor activity-modifying protein receptor complexes Roh, J, Chang, CL, Bhalla, A, Klein, C, Hsu, SY	J Biol Chem	2004
11693189	Receptor activity modifying proteins interaction with human and porcine calcitonin receptor-like receptor (CRLR) in HEK-293 cells Aiyar, N, Disa, J, Pullen, M, Nambi, P	Mol Cell Biochem	2001
8387282	Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma Kitamura, K, Kangawa, K, Kawamoto, M, Ichiki, Y, Nakamura, S, Matsuo, H, Eto, T	Biochem Biophys Res Commun	1993