Reactome | CRHR1,CRHR2-1 binds CRH,UCN

CRHR1,CRHR2-1 binds CRH,UCN

Stable Identifier

R-HSA-420173

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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Corticoliberin (CRH, aka corticotropin-releasing factor CRF) is a 41-amino acid amino peptide which, together with CRH-related peptides such as the urocortins (UCNs), play a role in coordinating endocrine, autonomic and behavioural responses to stress. These peptides exert their effects through binding and activation of two class B/Secretin family of GPCRs, CRHR1 and CRHR2 (aka CRFR1 and CRFR2 respectively). The activity of these receptors is mediated by coupling to the G protein alpha s subunit, stimulating adenylyl cyclase which increases intracellular cAMP levels (Donaldson et al. 1996). CRH and UCN bind with highest affinity to both CRHR1 and CRHR2-alpha receptors (Donaldson et al. 1996, Pioszak et al. 2008, Pal et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
18801728	Molecular recognition of corticotropin-releasing factor by its G-protein-coupled receptor CRFR1 Pioszak, AA, Parker, NR, Suino-Powell, K, Xu, HE	J. Biol. Chem.	2008
8612563	Cloning and characterization of human urocortin Donaldson, CJ, Sutton, SW, Perrin, MH, Corrigan, AZ, Lewis, KA, Rivier, JE, Vaughan, JM, Vale, WW	Endocrinology	1996
20966082	Structural basis for hormone recognition by the Human CRFR2{alpha} G protein-coupled receptor Pal, K, Swaminathan, K, Xu, HE, Pioszak, AA	J. Biol. Chem.	2010