CRHR1,CRHR2-1 binds CRH,UCN

Stable Identifier
R-HSA-420173
Type
Reaction [binding]
Species
Homo sapiens
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Corticoliberin (CRH, aka corticotropin-releasing factor CRF) is a 41-amino acid amino peptide which, together with CRH-related peptides such as the urocortins (UCNs), play a role in coordinating endocrine, autonomic and behavioural responses to stress. These peptides exert their effects through binding and activation of two class B/Secretin family of GPCRs, CRHR1 and CRHR2 (aka CRFR1 and CRFR2 respectively). The activity of these receptors is mediated by coupling to the G protein alpha s subunit, stimulating adenylyl cyclase which increases intracellular cAMP levels (Donaldson et al. 1996). CRH and UCN bind with highest affinity to both CRHR1 and CRHR2-alpha receptors (Donaldson et al. 1996, Pioszak et al. 2008, Pal et al. 2010).

Literature References
PubMed ID Title Journal Year
8612563 Cloning and characterization of human urocortin

Donaldson, CJ, Sutton, SW, Perrin, MH, Corrigan, AZ, Lewis, KA, Rivier, JE, Vaughan, JM, Vale, WW

Endocrinology 1996
18801728 Molecular recognition of corticotropin-releasing factor by its G-protein-coupled receptor CRFR1

Pioszak, AA, Parker, NR, Suino-Powell, K, Xu, HE

J. Biol. Chem. 2008
20966082 Structural basis for hormone recognition by the Human CRFR2{alpha} G protein-coupled receptor

Pal, K, Swaminathan, K, Xu, HE, Pioszak, AA

J. Biol. Chem. 2010
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