Reactome | Glucagon-like receptor 2 binds GLP2

Glucagon-like receptor 2 binds GLP2

Stable Identifier

R-HSA-420123

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

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Glucagon-like peptide 2 (GLP-2) (Drucker DJ 1999) is a 33-aa proglucagon-derived peptide produced by intestinal enteroendocrine cells. GLP-2 stimulates intestinal growth. The effects of GLP-2 are mediated by the GLP2 receptor (Munroe DG et al, 1999), which can couple with G protein alpha s subunit that activates adenylyl cyclase (Koehler JA et al, 2005).

Literature References

PubMed ID	Title	Journal	Year
15471943	The HeLa cell glucagon-like peptide-2 receptor is coupled to regulation of apoptosis and ERK1/2 activation through divergent signaling pathways Koehler, JA, Yusta, B, Drucker, DJ	Mol Endocrinol	2005
9990065	Prototypic G protein-coupled receptor for the intestinotrophic factor glucagon-like peptide 2 Munroe, DG, Gupta, AK, Kooshesh, F, Vyas, TB, Rizkalla, G, Wang, H, Demchyshyn, L, Yang, ZJ, Kamboj, RK, Chen, H, McCallum, K, Sumner-Smith, M, Drucker, DJ, Crivici, A	Proc Natl Acad Sci U S A	1999
10322410	Glucagon-like Peptide 2 Drucker, DJ	Trends Endocrinol Metab	1999