Glucagon-like receptor 2 binds GLP2

Stable Identifier
R-HSA-420123
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Glucagon-like peptide 2 (GLP-2) (Drucker DJ 1999) is a 33-aa proglucagon-derived peptide produced by intestinal enteroendocrine cells. GLP-2 stimulates intestinal growth. The effects of GLP-2 are mediated by the GLP2 receptor (Munroe DG et al, 1999), which can couple with G protein alpha s subunit that activates adenylyl cyclase (Koehler JA et al, 2005).

Literature References
PubMed ID Title Journal Year
15471943 The HeLa cell glucagon-like peptide-2 receptor is coupled to regulation of apoptosis and ERK1/2 activation through divergent signaling pathways

Koehler, JA, Yusta, B, Drucker, DJ

Mol Endocrinol 2005
9990065 Prototypic G protein-coupled receptor for the intestinotrophic factor glucagon-like peptide 2

Munroe, DG, Gupta, AK, Kooshesh, F, Vyas, TB, Rizkalla, G, Wang, H, Demchyshyn, L, Yang, ZJ, Kamboj, RK, Chen, H, McCallum, K, Sumner-Smith, M, Drucker, DJ, Crivici, A

Proc Natl Acad Sci U S A 1999
10322410 Glucagon-like Peptide 2

Drucker, DJ

Trends Endocrinol Metab 1999
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created