Reactome | GHRHR [plasma membrane]

GHRHR [plasma membrane]

Stable Identifier

R-HSA-420079

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Growth hormone-releasing hormone receptor, GHRHR_HUMAN

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Leishmania infection (Homo sapiens)
    - Leishmania parasite growth and survival (Homo sapiens)
      - Anti-inflammatory response favouring Leishmania parasite infection (Homo sapiens)
        
        ADORA2B mediated anti-inflammatory cytokines production (Homo sapiens)
        
        ADORA2B (in Ade-Rib:ADORA2B:Heterotrimeric G-protein Gs) exchanges GDP for GTP on Gs (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        GHRH receptor:GHRH [plasma membrane] (Homo sapiens)
        
        GHRHR [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q02643 GHRHR

Gene Names

GHRHR

Chain

signal peptide:1-22, chain:23-423

Reference Genes

BioGPS Gene:2692 GHRHR

COSMIC (genes):GHRHR GHRHR

CTD Gene:2692 GHRHR

dbSNP Gene:2692 GHRHR

ENSEMBL:ENSG00000106128 GHRHR

HGNC:4266 GHRHR

KEGG Gene (Homo sapiens):2692 GHRHR

Monarch:2692 GHRHR

NCBI Gene:2692 GHRHR

OMIM:139191 GHRHR

UCSC:Q02643 GHRHR

Reference Transcript

RefSeq:NM_000823.3 GHRHR

Other Identifiers

0005220368

1123_at

11735863_a_at

11742326_a_at

11742327_x_at

11753253_a_at

17044877

207825_s_at

211544_s_at

2692

2995609

2995610

2995611

2995613

2995617

2995619

2995621

2995622

2995625

2995626

2995627

2995628

2995630

2995633

2995634

2995636

2995637

8132130

A_14_P127277

A_23_P8497

A_33_P3232655

GE480464

GO:0000003

GO:0002376

GO:0002862

GO:0003674

GO:0004888

GO:0004930

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005635

GO:0005637

GO:0005640

GO:0005737

GO:0005886

GO:0006810

GO:0006950

GO:0007165

GO:0007166

GO:0007186

GO:0007188

GO:0007189

GO:0007190

GO:0007267

GO:0007568

GO:0007595

GO:0008150

GO:0008283

GO:0008284

GO:0008340

GO:0008528

GO:0009986

GO:0016020

GO:0016021

GO:0016363

GO:0016520

GO:0017046

GO:0019838

GO:0019933

GO:0021700

GO:0021984

GO:0030104

GO:0030141

GO:0030154

GO:0030879

GO:0031410

GO:0032868

GO:0032869

GO:0033143

GO:0040007

GO:0040018

GO:0042383

GO:0042445

GO:0042592

GO:0043226

GO:0043567

GO:0043568

GO:0043627

GO:0046010

GO:0046887

GO:0048469

GO:0048609

GO:0048856

GO:0051246

GO:0051384

GO:0060124

GO:0060133

GO:0071333

HMNXSV003025452

ILMN_1714884

ILMN_1740186

L01406_at

PH_hs_0000090

TC07000200.hg

g4503996_3p_a_at

Participates

as an input of

GHRH receptor binds GHRH (Homo sapiens)

as a member of

GPCRs that activate Gs [plasma membrane] (Homo sapiens)

as a component of

GHRH receptor:GHRH [plasma membrane] (Homo sapiens)

Inferred To

GHRHR [plasma membrane] (Canis familiaris)

GHRHR [plasma membrane] (Gallus gallus)

Ghrhr [plasma membrane] (Mus musculus)

Ghrhr [plasma membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_000814.2

ZINC - World Drugs

GHRHR_HUMAN

Guide to Pharmacology - Targets

247

OpenTargets

ENSG00000106128

ZINC - FDA approved

GHRHR_HUMAN

ZINC - Substances

GHRHR_HUMAN

ZINC target

Q02643

ZINC - Biogenic

GHRHR_HUMAN

PRO

Q02643

GlyGen

Q02643

PDB

7CZ5, 2XDG

GeneCards

Q02643

HPA

ENSG00000106128-GHRHR

Ensembl

ENST00000326139, ENSG00000106128, ENSP00000320180

Pharos - Targets

Q02643

ZINC - Predictions - Purchasable

GHRHR_HUMAN

Orphanet

16123

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