Reactome | CDC42BPB [cytosol]

CDC42BPB [cytosol]

Stable Identifier

R-HSA-419873

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

MRCK beta, Serine/threonine-protein kinase MRCK beta, MRCKB_HUMAN, CDC42-binding protein kinase beta

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9Y5S2 CDC42BPB

Gene Names

CDC42BPB, KIAA1124

Chain

chain:1-1711

Reference Genes

BioGPS Gene:9578 CDC42BPB

COSMIC (genes):CDC42BPB CDC42BPB

CTD Gene:9578 CDC42BPB

dbSNP Gene:9578 CDC42BPB

ENSEMBL:ENSG00000198752 CDC42BPB

HGNC:1738 CDC42BPB

Monarch:9578 CDC42BPB

NCBI Gene:9578 CDC42BPB

OMIM:614062 CDC42BPB

UCSC:Q9Y5S2 CDC42BPB

Reference Transcript

RefSeq:NM_006035.3 CDC42BPB

Other Identifiers

11740260_a_at

1557963_PM_at

1557963_at

16796938

217849_PM_s_at

217849_s_at

3580499

3580500

3580501

3580502

3580505

3580507

3580509

3580510

3580511

3580512

3580513

3580514

3580515

3580520

3580521

3580522

3580523

3580524

3580526

3580528

3580529

3580530

3580531

3580532

3580533

3580534

3580536

3580538

3580539

3580540

3580542

3580545

3580546

3580548

3580550

3580552

3580554

3580556

3580557

3580560

3580561

3580562

3580563

3580564

3580568

3580570

3580571

3580572

3580576

3580579

3580580

3580581

3580583

3580587

3580602

3580603

3580604

56549_at

76027_at

7981387

84805_at

9578

A_23_P380766

GE80225

GO:0000287

GO:0003824

GO:0004672

GO:0004674

GO:0005524

GO:0005737

GO:0005829

GO:0005856

GO:0005886

GO:0005911

GO:0006468

GO:0007010

GO:0007163

GO:0007165

GO:0016020

GO:0016477

GO:0016740

GO:0030027

GO:0030036

GO:0031032

GO:0031252

GO:0031267

GO:0042641

GO:0042995

GO:0043226

GO:0044877

GO:0046872

GO:0048870

GO:0070062

GO:0070161

GO:0106310

GO:0140096

HMNXSV003012690

HMNXSV003026946

Hs2.378168.1.A1_3p_at

ILMN_1689989

PH_hs_0025557

RNA95485|RNS_567_153

TC14001534.hg

g5174412_3p_a_at

Participates

as a candidate of

as a member of

CDC42 effectors [cytosol] (Homo sapiens)

Inferred To

CDC42BPB [cytosol] (Bos taurus)

CDC42BPB [cytosol] (Caenorhabditis elegans)

CDC42BPB [cytosol] (Canis familiaris)

CDC42BPB [cytosol] (Drosophila melanogaster)

CDC42BPB [cytosol] (Gallus gallus)

CDC42BPB [cytosol] (Mus musculus)

CDC42BPB [cytosol] (Rattus norvegicus)

CDC42BPB [cytosol] (Sus scrofa)

Cross References

ZINC - World Drugs

MRCKB_HUMAN

Guide to Pharmacology - Targets

1508

ENSEMBL

ENST00000361246, ENSP00000355237

OpenTargets

ENSG00000198752

ZINC - FDA approved

MRCKB_HUMAN

ZINC - Substances

MRCKB_HUMAN

ZINC - Biogenic

MRCKB_HUMAN

ZINC target

Q9Y5S2

PRO

Q9Y5S2

PDB

4UAL, 4UAK, 3TKU, 5OTE, 3QFV, 5OTF

ZINC - Investigational

MRCKB_HUMAN

IntEnz

2.7.11.1

HPA

ENSG00000198752-CDC42BPB

Pharos - Targets

Q9Y5S2

ZINC - Predictions - Purchasable

MRCKB_HUMAN

HMDB Protein

HMDBP08486

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P60953 CDC42	3	CDC42 [cytosol] (R-HSA-442630) CDC42 [plasma membrane] (R-HSA-449545) CDC42 [endoplasmic reticulum membrane] (R-HSA-5672086)	0.547	2
UniProt:Q05513 PRKCZ	5	pS, p-T410-PRKCZ [cytosol] (R-HSA-9632824) PRKCZ [cytosol] (R-HSA-58218) p-T410,T563-PRKCZ [cytosol] (R-HSA-5218698) p-T410-PRKCZ [cytosol] (R-HSA-437181) PRKCZ [cell junction] (R-HSA-2134483)	0.527	2
UniProt:Q07157 TJP1	5	TJP1 [cytosol] (R-HSA-532659) TJP1 [Golgi-associated vesicle membrane] (R-HSA-3209843) TJP1 [plasma membrane] (R-HSA-3209845) TJP1 (?-?) [plasma membrane] (R-HSA-3209844) TJP1 [cell junction] (R-HSA-8936023)	0.463	3

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