CALCA(83-119) binds CALCR

Stable Identifier
R-HSA-419843
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Synonyms
Calcitonin receptor binds calcitonin
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The sensory neuropeptide calcitonin gene-related peptide 1 (CALCA, aka CGRP) plays an important role in primary headaches. The CALC1 gene produces a prepropeptide from which calcitonin (CALCA(83-119)) is a cleavage product (Nelkin BD et al, 1984). CALCA(83-119) is a polypeptide hormone that is produced in the thyroid gland. It acts to reduce blood calcium, opposing the effects of parathyroid hormone. It also induces vasodilation of coronary, cerebral and systemic vasculature. The CALCA(83-119) receptor (CALCR) (Gorn AH et al, 1992) binds CALCA(83-119) and mediates its actions. The ligand:receptor complex couples to the G protein alpha s subunit, which stimulates adenylyl cyclase and increases intracellular cAMP levels (Gorn AH et al, 1992). CALCA(83-119) antagonists are effective in migraine treatment.

Literature References
PubMed ID Title Journal Year
1331173 Cloning, characterization, and expression of a human calcitonin receptor from an ovarian carcinoma cell line

Gorn, AH, Lin, HY, Yamin, M, Auron, PE, Flannery, MR, Tapp, DR, Manning, CA, Lodish, HF, Krane, SM, Goldring, SR

J Clin Invest 1992
6148938 Structure and expression of a gene encoding human calcitonin and calcitonin gene related peptide

Nelkin, BD, Rosenfeld, KI, de Bustros, A, Leong, SS, Roos, BA, Baylin, SB

Biochem Biophys Res Commun 1984
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