Reactome | CALCA(83-119) [extracellular region]

CALCA(83-119) [extracellular region]

Stable Identifier

R-HSA-419836

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Calcitonin gene-related peptide 1, CALCA, CALCA_HUMAN

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Leishmania infection (Homo sapiens)
    - Leishmania parasite growth and survival (Homo sapiens)
      - Anti-inflammatory response favouring Leishmania parasite infection (Homo sapiens)
        
        ADORA2B mediated anti-inflammatory cytokines production (Homo sapiens)
        
        ADORA2B (in Ade-Rib:ADORA2B:Heterotrimeric G-protein Gs) exchanges GDP for GTP on Gs (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        CGRP1 receptor:CGRP [plasma membrane] (Homo sapiens)
        
        CGRP ligands [extracellular region] (Homo sapiens)
        
        CALCA(83-119) [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P06881 CALCA

Gene Names

CALCA, CALC1

Chain

signal peptide:1-25, propeptide:26-80, peptide:83-119, propeptide:125-128

Reference Genes

BioGPS Gene:796 CALCA

COSMIC (genes):CALCA CALCA

CTD Gene:796 CALCA

dbSNP Gene:796 CALCA

ENSEMBL:ENSG00000110680 CALCA

Monarch:796 CALCA

NCBI Gene:796 CALCA

OMIM:114130 CALCA

UCSC:P06881 CALCA

Reference Transcript

RefSeq:NM_001033953.2 CALCA

Other Identifiers

11730414_a_at

11730415_s_at

217495_3p_x_at

217495_x_at

217561_at

3321644

3364128

3364129

3364137

3364138

3364139

36299_at

36300_at

796

A_24_P198178

GO:0001935

GO:0001944

GO:0002031

GO:0002376

GO:0003013

GO:0003674

GO:0005102

GO:0005179

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0006464

GO:0006468

GO:0006810

GO:0007155

GO:0007159

GO:0007165

GO:0007186

GO:0007189

GO:0007190

GO:0007267

GO:0008150

GO:0008217

GO:0008283

GO:0010523

GO:0016192

GO:0030154

GO:0031623

GO:0032730

GO:0032757

GO:0040011

GO:0042592

GO:0043542

GO:0044877

GO:0045651

GO:0045671

GO:0045779

GO:0048856

GO:0048870

GO:0051480

GO:0051482

GO:0097647

GO:0097755

GO:1990408

Hs.288190.0.A1_3p_at

Hs.37058.2.S1_3p_a_at

Hs.37058.2.S1_3p_s_at

Hs.37058.2.S1_3p_x_at

ILMN_1807034

ILMN_2327244

TC11003065.hg

X15943_at

Participant Of

hasMember

CGRP ligands [extracellular region]

Cross References

ZINC - Investigational

CALCA_HUMAN

RefSeq

NP_001029125.1

OpenTargets

ENSG00000110680

GeneCards

P06881

ZINC - Substances

CALCA_HUMAN

ZINC target

P06881

Ensembl

ENSP00000417833, ENST00000486207, ENSP00000354286, ENST00000361010, ENSG00000110680

ZINC - Predictions - Purchasable

CALCA_HUMAN

PDB

1LS7, 6E3Y

HMDB Protein

HMDBP02095

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62873 GNB1	5	GNB1 [photoreceptor disc membrane] (R-HSA-55373) GNB1 [plasma membrane] (R-HSA-164347) Unfolded GNB1 [cytosol] (R-HSA-6814200) Partially folded GNB1 [cytosol] (R-HSA-8850526) GNB1 [cytosol] (R-HSA-6814412)	0.488	2

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