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OPN1LW [photoreceptor disc membrane]
Stable Identifier
R-HSA-419769
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
photoreceptor disc membrane
Synonyms
Red-sensitive opsin, OPSR_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Sensory Perception (Homo sapiens)
Visual phototransduction (Homo sapiens)
The retinoid cycle in cones (daylight vision) (Homo sapiens)
OPN1LW binds 11cRAL (Homo sapiens)
OPN1LW [photoreceptor disc membrane] (Homo sapiens)
at-retinyl is hydrolysed from R* to release atRAL (Homo sapiens)
Cone apo-opsins [photoreceptor disc membrane] (Homo sapiens)
OPN1LW [photoreceptor disc membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
G-alpha(t):G-beta-gamma:Opsins complex dissociates to active G-alpha(t) (Homo sapiens)
G-alpha(t):GTP:G-beta-gamma:Opsins [plasma membrane] (Homo sapiens)
Opsins:photon [photoreceptor disc membrane] (Homo sapiens)
Light-sensing opsins [photoreceptor disc membrane] (Homo sapiens)
OPN1LW [photoreceptor disc membrane] (Homo sapiens)
Opsins:photon [photoreceptor disc membrane] (Homo sapiens)
Light-sensing opsins [photoreceptor disc membrane] (Homo sapiens)
OPN1LW [photoreceptor disc membrane] (Homo sapiens)
Opsins act as GEFs for G alpha-t (Homo sapiens)
G-alpha(t):GDP:G-beta-gamma:Opsins [plasma membrane] (Homo sapiens)
Opsins:photon [photoreceptor disc membrane] (Homo sapiens)
Light-sensing opsins [photoreceptor disc membrane] (Homo sapiens)
OPN1LW [photoreceptor disc membrane] (Homo sapiens)
G-alpha(t):GTP:G-beta-gamma:Opsins [plasma membrane] (Homo sapiens)
Opsins:photon [photoreceptor disc membrane] (Homo sapiens)
Light-sensing opsins [photoreceptor disc membrane] (Homo sapiens)
OPN1LW [photoreceptor disc membrane] (Homo sapiens)
Opsins:photon [photoreceptor disc membrane] (Homo sapiens)
Light-sensing opsins [photoreceptor disc membrane] (Homo sapiens)
OPN1LW [photoreceptor disc membrane] (Homo sapiens)
Opsins binds G alpha-t (Homo sapiens)
G-alpha(t):GDP:G-beta-gamma:Opsins [plasma membrane] (Homo sapiens)
Opsins:photon [photoreceptor disc membrane] (Homo sapiens)
Light-sensing opsins [photoreceptor disc membrane] (Homo sapiens)
OPN1LW [photoreceptor disc membrane] (Homo sapiens)
Opsins:photon [photoreceptor disc membrane] (Homo sapiens)
Light-sensing opsins [photoreceptor disc membrane] (Homo sapiens)
OPN1LW [photoreceptor disc membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Opsins (Homo sapiens)
Light stimulates opsin receptors (Homo sapiens)
Light-sensing opsins [photoreceptor disc membrane] (Homo sapiens)
OPN1LW [photoreceptor disc membrane] (Homo sapiens)
Opsins:photon [photoreceptor disc membrane] (Homo sapiens)
Light-sensing opsins [photoreceptor disc membrane] (Homo sapiens)
OPN1LW [photoreceptor disc membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P04000 OPN1LW
Gene Names
OPN1LW, RCP
Chain
chain:1-364
Reference Genes
BioGPS Gene:5956 OPN1LW
COSMIC (genes):OPN1LW OPN1LW
CTD Gene:5956 OPN1LW
dbSNP Gene:5956 OPN1LW
ENSEMBL:ENSG00000102076 OPN1LW
ENSEMBL_homo_sapiens_GENE:ENSG00000102076.10 OPN1LW
HGNC:9936 OPN1LW
KEGG Gene (Homo sapiens):5956 OPN1LW
Monarch:5956 OPN1LW
NCBI Gene:5956 OPN1LW
OMIM:300822 OPN1LW
UCSC:P04000 OPN1LW
Reference Transcript
RefSeq:NM_020061.5 OPN1LW
Other Identifiers
11735456_s_at
17108234
17108244
17108254
221327_3p_s_at
221327_PM_s_at
221327_s_at
3996145
3996146
3996147
3996148
3996149
3996151
3996152
3996157
3996158
3996174
3996175
3996177
3996178
3996179
3996180
3996184
3996185
3996202
3996203
3996205
3996208
3996209
3996215
3996216
5956
8170811
8170816
8170825
A_23_P96623
GE567795
GO:0000910
GO:0001750
GO:0004930
GO:0005515
GO:0005886
GO:0005929
GO:0007165
GO:0007186
GO:0007601
GO:0007602
GO:0008020
GO:0009584
GO:0009881
GO:0016020
GO:0023052
GO:0032467
GO:0043226
GO:0050877
GO:0050896
GO:0060089
GO:0071482
GO:0097381
HMNXSV003040100
ILMN_1677153
K03494_s_at
PH_hs_0034119
TC0X000764.hg
TC0X000765.hg
TC0X000766.hg
TC0X001932.hg
TC0X001934.hg
Z68193_at
g4503964_3p_s_at
Participates
as an input of
OPN1LW binds 11cRAL (Homo sapiens)
as a member of
Cone apo-opsins [photoreceptor disc membrane] (Homo sapiens)
Light-sensing opsins [photoreceptor disc membrane] (Homo sapiens)
Other forms of this molecule
OPN1LW P307L [photoreceptor disc membrane]
OPN1LW C203R [photoreceptor disc membrane]
OPN1LW R247* [photoreceptor disc membrane]
OPN1LW G338E [photoreceptor disc membrane]
11cRAL-OPN1LW [photoreceptor disc membrane]
at-retinyl-OPN1LW [photoreceptor disc membrane]
Inferred To
LOC494564 [photoreceptor disc membrane]
(Sus scrofa)
opn1lw2 [photoreceptor disc membrane]
(Danio rerio)
Homologues of OPN1LW [photoreceptor disc membrane]
(Danio rerio)
opn1lw [photoreceptor disc membrane]
(Xenopus tropicalis)
OPN1LW [photoreceptor disc membrane]
(Bos taurus)
OPN1LW [photoreceptor disc membrane]
(Caenorhabditis elegans)
OPN1LW [photoreceptor disc membrane]
(Canis familiaris)
OPN1LW [photoreceptor disc membrane]
(Gallus gallus)
Opn1mw [photoreceptor disc membrane]
(Mus musculus)
Opn1mw [photoreceptor disc membrane]
(Rattus norvegicus)
opn1lw1 [photoreceptor disc membrane]
(Danio rerio)
Cross References
RefSeq
NP_064445.2
Guide to Pharmacology - Targets
2961
OpenTargets
ENSG00000102076
GeneCards
P04000
HPA
ENSG00000102076-OPN1LW
Ensembl
ENSP00000358967
,
ENSG00000102076
,
ENST00000369951
PRO
P04000
Pharos - Targets
P04000
Orphanet
16592
PDB
8IU2
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8IXM6 NRM
0.556
3
UniProt:A5PKU2 A5PKU2
0.556
3
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