SEMA4D interacts with Plexin-B1:Met

Stable Identifier
R-HSA-419646
Type
Reaction [transition]
Species
Homo sapiens
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Sema4D binds Plexin-B1 to induce repulsive or attractive effects in neuronal and nonneuronal cells. Plexins constitute a large family of transmembrane proteins that function as receptors for semaphorins and their interaction governs cell adhesion and migration in a variety of tissues. All B-class plexins can interact with the receptor tyrosine kinases Met and ErbB2. The binding of Sema4D to plexin-B1 stimulates the intrinsic tyrosine kinase activity of Met, leading to the phosphorylation of both Plexin-B1 and Met. The phosphorylation of the plexin-B1/Met complex induced by Sema4D is crucial for epithelial cell migration and invasive growth. Sequence alignment reveals the presence of 13 conserved tyrosine residues (highly conserved sites 1918, 1953, 2038), but the specific tyrosine residues phosphorylated in the cytoplasmic domain of plexins in response to semaphorin stimulation have not yet been identified.

Literature References
PubMed ID Title Journal Year
18025083 ErbB-2 and met reciprocally regulate cellular signaling via plexin-B1

Swiercz, JM, Worzfeld, T, Offermanns, S

J Biol Chem 2008
12198496 The semaphorin 4D receptor controls invasive growth by coupling with Met

Giordano, S, Corso, S, Conrotto, P, Artigiani, S, Gilestro, G, Barberis, D, Tamagnone, L, Comoglio, PM

Nat Cell Biol 2002
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Catalyst Activity
Title
protein tyrosine kinase activity of Plexin-B1:Met [plasma membrane]
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Orthologous Events
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