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MET [plasma membrane]
Stable Identifier
R-HSA-419603
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Hepatocyte growth factor receptor, MET_HUMAN
Icon
Locations in the PathwayBrowser for interactor UniProt:O43157 PLXNB1
Expand all
Developmental Biology (Homo sapiens)
MITF-M-regulated melanocyte development (Homo sapiens)
MITF-M-dependent gene expression (Homo sapiens)
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation (Homo sapiens)
MITF-M-dependent MET gene expression (Homo sapiens)
MET [plasma membrane] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Bacterial Infection Pathways (Homo sapiens)
Listeria monocytogenes entry into host cells (Homo sapiens)
InlB-mediated entry of Listeria monocytogenes into host cell (Homo sapiens)
InlB binds MET (Homo sapiens)
MET [plasma membrane] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by MECP2 (Homo sapiens)
MECP2 regulates neuronal receptors and channels (Homo sapiens)
MET gene transcription is stimulated by MECP2 (Homo sapiens)
MET [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by MET (Homo sapiens)
MET Receptor Activation (Homo sapiens)
HGF dimer binds MET (Homo sapiens)
MET [plasma membrane] (Homo sapiens)
Negative regulation of MET activity (Homo sapiens)
Drug-mediated inhibition of MET activation (Homo sapiens)
Anti-MET recombinant therapeutic antibodies bind MET (Homo sapiens)
MET [plasma membrane] (Homo sapiens)
MET binds LRIG1 (Homo sapiens)
MET [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P08581 MET
Gene Names
MET
Chain
signal peptide:1-24, chain:25-1390
Reference Genes
BioGPS Gene:4233 MET
COSMIC (genes):MET MET
CTD Gene:4233 MET
dbSNP Gene:4233 MET
ENSEMBL:ENSG00000105976 MET
ENSEMBL_homo_sapiens_GENE:ENSG00000105976.16 MET
HGNC:7029 MET
KEGG Gene (Homo sapiens):4233 MET
Monarch:4233 MET
NCBI Gene:4233 MET
OMIM:164860 MET
UCSC:P08581 MET
Reference Transcript
RefSeq:NM_001127500.2 MET
RefSeq:NM_000245.3 MET
Other Identifiers
11716407_a_at
11716408_a_at
11735116_a_at
11751246_a_at
11752248_a_at
11754144_a_at
1609_g_at
17050591
1812_s_at
203510_PM_at
203510_at
211599_PM_x_at
211599_x_at
213807_PM_x_at
213807_x_at
213816_PM_s_at
213816_s_at
3020342
3020344
3020348
3020349
3020350
3020363
3020365
3020366
3020367
3020374
3020377
3020378
3020379
3020380
3020381
3020382
3020384
3020385
3020387
3020390
3020391
3020392
3020393
3020395
3020396
3020397
3020399
3020401
3020402
3020403
3020404
3020405
3020406
3020407
3020408
3020409
3020410
3020411
3020412
3020420
35684_at
4233
46302_at
8135601
A_14_P102324
A_14_P113351
A_14_P119122
A_14_P137799
A_23_P145844
A_23_P145846
A_23_P359245
GE57468
GO:0000166
GO:0001886
GO:0001889
GO:0003824
GO:0004672
GO:0004713
GO:0004714
GO:0005008
GO:0005515
GO:0005524
GO:0005576
GO:0005886
GO:0006351
GO:0006355
GO:0006468
GO:0006909
GO:0006914
GO:0007010
GO:0007165
GO:0007166
GO:0007169
GO:0007399
GO:0009925
GO:0009986
GO:0010507
GO:0012501
GO:0016020
GO:0016192
GO:0016301
GO:0016310
GO:0016477
GO:0016740
GO:0017154
GO:0019903
GO:0023052
GO:0030154
GO:0030182
GO:0031016
GO:0031116
GO:0035024
GO:0036211
GO:0042802
GO:0043235
GO:0045944
GO:0048012
GO:0048754
GO:0048856
GO:0048870
GO:0050896
GO:0050918
GO:0051497
GO:0060089
GO:0061436
GO:0065003
GO:0070495
GO:0071526
GO:0098772
GO:0140096
GO:0140677
GO:1901299
GO:1905098
GO:2001028
HMNXSV003052945
Hs.285754.0.S2_3p_at
Hs.285754.1.S1_3p_a_at
ILMN_1715175
PH_hs_0025104
TC07000722.hg
g625085_3p_s_at
Participates
as an input of
InlB binds MET (Homo sapiens)
MET binds LRIG1 (Homo sapiens)
Anti-MET recombinant therapeutic antibodies bind MET (Homo sapiens)
HGF dimer binds MET (Homo sapiens)
as a component of
InlB:MET [plasma membrane] (Homo sapiens)
MET:Ub-LRIG1 [plasma membrane] (Homo sapiens)
MET:LRIG1 [plasma membrane] (Homo sapiens)
Plexin-B1:Met [plasma membrane] (Homo sapiens)
MET:p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
Anti-MET MAbs:MET [plasma membrane] (Homo sapiens)
HGF dimer:MET [plasma membrane] (Homo sapiens)
as an output of
MITF-M-dependent MET gene expression (Homo sapiens)
MET gene transcription is stimulated by MECP2 (Homo sapiens)
Other forms of this molecule
p-Y1234,Y1235,Y1356-MET [plasma membrane]
p-Y1349,Y1356-MET [plasma membrane]
MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane]
MonoUb-K,p-Y1003,4Y-MET [plasma membrane]
p-Y1003,4Y-MET [plasma membrane]
p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane]
Inferred To
MET [plasma membrane]
(Bos taurus)
MET [plasma membrane]
(Caenorhabditis elegans)
MET [plasma membrane]
(Canis familiaris)
MET [plasma membrane]
(Danio rerio)
MET [plasma membrane]
(Gallus gallus)
MET [plasma membrane]
(Mus musculus)
MET [plasma membrane]
(Rattus norvegicus)
MET [plasma membrane]
(Sus scrofa)
MET [plasma membrane]
(Xenopus tropicalis)
Homologues of MET [plasma membrane]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_001120972.1
,
NP_000236.2
ZINC - World Drugs
MET_HUMAN
Guide to Pharmacology - Targets
1815
OpenTargets
ENSG00000105976
ZINC - FDA approved
MET_HUMAN
ZINC - Substances
MET_HUMAN
ZINC target
P08581
ZINC - Biogenic
MET_HUMAN
PRO
P08581
PDB
3DKF
,
3C1X
,
7B42
,
1FYR
,
8AU5
,
3F66
,
3R7O
,
6I04
,
3CCN
,
7V3S
,
7B44
,
7B3T
,
4R1V
,
8OWG
,
4DEH
,
3VW8
,
4K3J
,
8OUV
,
6SDE
,
3BUX
,
5LSP
,
1R0P
,
7B3W
,
5HTI
,
3RHK
,
2UZY
,
5HOA
,
2WKM
,
7B41
,
8AW1
,
2RFN
,
3EFK
,
3ZXZ
,
3ZC5
,
3CD8
,
4XMO
,
5DG5
,
6UBW
,
4AP7
,
3U6I
,
6SD9
,
7Y4T
,
5HOR
,
7MOA
,
3U6H
,
3LQ8
,
7V3R
,
5HLW
,
8GVJ
,
1SSL
,
1SHY
,
4KNB
,
5EOB
,
4IWD
,
4GG7
,
3ZCL
,
4MXC
,
3Q6W
,
8AN8
,
8AU3
,
5UAB
,
5UAD
,
3ZZE
,
3I5N
,
7MO9
,
3CTH
,
1R1W
,
5T3Q
,
3DKC
,
7B43
,
4O3U
,
8OUU
,
5HNI
,
5EYC
,
4GG5
,
4DEI
,
6SDD
,
8OW3
,
6GCU
,
5HO6
,
4R1Y
,
3A4P
,
7B3Z
,
4AOI
,
7B40
,
4EEV
,
3DKG
,
2UZX
,
8OV7
,
4O3T
,
7Y4U
,
4XYF
,
3L8V
,
7B3Q
,
8ANS
,
3QTI
,
3EFJ
,
4DEG
,
6SDC
,
7MOB
,
5EYD
,
7B3V
,
7MO7
,
3CE3
,
8OVZ
,
3Q6U
,
2G15
,
2RFS
,
5YA5
,
3ZBX
,
3CTJ
,
6WVZ
,
2WGJ
,
2WD1
,
7MO8
,
3F82
ZINC - Investigational
MET_HUMAN
ZINC - Metabolites
MET_HUMAN
GeneCards
P08581
HPA
ENSG00000105976-MET
Ensembl
ENSP00000380860
,
ENST00000436117
,
ENSP00000410980
,
ENST00000318493
,
ENST00000397752
,
ENSP00000317272
,
ENSG00000105976
Pharos - Targets
P08581
ZINC - Predictions - Purchasable
MET_HUMAN
Orphanet
16392
HMDB Protein
HMDBP09447
Interactors (26)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P22681 CBL
20
PolyUb,p-Y-CBL [cytosol]
(R-HSA-9763893)
CBL R420G [cytosol]
(R-HSA-9706203)
CBL R420Q [cytosol]
(R-HSA-9706186)
CBL Y371H [cytosol]
(R-HSA-9706680)
CBL H398Y [cytosol]
(R-HSA-9706639)
CBL P417A [cytosol]
(R-HSA-9706636)
CBL S376F [cytosol]
(R-HSA-9706643)
CBL E366_Q409del [cytosol]
(R-HSA-9706179)
CBL del366-477 [cytosol]
(R-HSA-9706176)
CBL R499L [cytosol]
(R-HSA-9706678)
CBL L380P [cytosol]
(R-HSA-9706630)
CBL L287R [cytosol]
(R-HSA-9706693)
CBL L380R [cytosol]
(R-HSA-9706635)
CBL G375P [cytosol]
(R-HSA-9706219)
CBL P417L [cytosol]
(R-HSA-9706634)
CBL H398Q [cytosol]
(R-HSA-9706633)
CBL P417R [cytosol]
(R-HSA-9706632)
CBL R499* [cytosol]
(R-HSA-9706670)
CBL H398R [cytosol]
(R-HSA-9706638)
CBL H398P [cytosol]
(R-HSA-9706637)
0.863
17
UniProt:P14210 HGF
5
HGF(32-494) [platelet alpha granule lumen]
(R-HSA-139866)
HGF(495-728) [platelet alpha granule lumen]
(R-HSA-141764)
pro-HGF [extracellular region]
(R-HSA-6800218)
HGF(495-728) [extracellular region]
(R-HSA-141767)
HGF(32-494) [extracellular region]
(R-HSA-56497)
0.851
7
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.8
8
UniProt:P12931 SRC
6
p-Y419-SRC [nucleoplasm]
(R-HSA-8937690)
SRC [cytosol]
(R-HSA-9628701)
p-Y419-SRC [cytosol]
(R-HSA-8964276)
MyrG-SRC [plasma membrane]
(R-HSA-8876922)
MyrG,p-Y530-SRC [plasma membrane]
(R-HSA-377598)
MyrG-p-Y419-SRC [plasma membrane]
(R-HSA-1810408)
0.787
7
UniProt:O43157 PLXNB1
2
PLXNB1 [plasma membrane]
(R-HSA-3008951)
p-Y-PLXNB1 [plasma membrane]
(R-HSA-419609)
0.775
9
UniProt:Q12913 PTPRJ
2
PTPRJ [plasma membrane]
(R-HSA-6785269)
PTPRJ [specific granule membrane]
(R-HSA-6799570)
0.733
5
UniProt:P18031 PTPN1
2
PTPN1 [cytosol]
(R-HSA-210625)
PTPN1 [endosome membrane]
(R-HSA-9815895)
0.713
3
UniProt:P14210-6 HGF
0.676
3
UniProt:Q96EY1 DNJA3
0.636
4
UniProt:P0DQD2 inlB
1
InlB [peptidoglycan-based cell wall]
(R-LMO-9637760)
0.618
4
UniProt:P08581 MET
7
p-Y1234,Y1235,Y1356-MET [plasma membrane]
(R-HSA-6807014)
p-Y1349,Y1356-MET [plasma membrane]
(R-HSA-6807032)
MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane]
(R-HSA-8875181)
MonoUb-K,p-Y1003,4Y-MET [plasma membrane]
(R-HSA-8875180)
p-Y1003,4Y-MET [plasma membrane]
(R-HSA-8874689)
MET [plasma membrane]
(R-HSA-419603)
p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane]
(R-HSA-6806973)
0.609
2
UniProt:Q06124 PTPN11
4
p-Y542-PTPN11 [cytosol]
(R-HSA-1369081)
PTPN11 [nucleoplasm]
(R-HSA-8937745)
PTPN11 [cytosol]
(R-HSA-162563)
p-Y542,Y580-PTPN11 [cytosol]
(R-HSA-162573)
0.609
13
UniProt:Q00944
11
phospho-pY-PTK2 [cytosol]
(R-GGA-9632393)
phospho-p-Y194,Y397,Y576,Y577-PTK2 [cytosol]
(R-GGA-8874613)
phospho-p-Y194,Y397-PTK2 [cytosol]
(R-GGA-8874600)
phospho-p-5Y-PTK2 [cytosol]
(R-GGA-5218711)
phospho-p-5Y,S732-PTK2 [cytosol]
(R-GGA-5229006)
phospho-p-6Y,S732-PTK2 [cytosol]
(R-GGA-5218694)
PTK2(773-1052) [cytosol]
(R-GGA-202829)
PTK2(1-772) [cytosol]
(R-GGA-202827)
PTK2 [cytosol]
(R-GGA-201621)
phospho-p-Y397-PTK2 [cytosol]
(R-GGA-354068)
phospho-p-6Y-PTK2 [cytosol]
(R-GGA-354128)
0.602
5
UniProt:Q96S59 RANBP9
1
RANBP9 [cytosol]
(R-HSA-374586)
0.593
3
UniProt:Q16827 PTPRO
1
PTPRO [plasma membrane]
(R-HSA-9603761)
0.59
2
UniProt:P35918 Kdr
5
p-Y799,Y1052,Y1172-Kdr [plasma membrane]
(R-MMU-9860469)
Kdr [plasma membrane]
(R-MMU-9860502)
Mouse Vegfr2-Human CSF1R fusion protein [plasma membrane]
(R-MMU-5218738)
VEGFR2 [plasma membrane]
(R-MMU-195382)
phospho-p-6Y-VEGFR2 [plasma membrane]
(R-MMU-4420103)
0.563
3
UniProt:Q08048 Hgf
6
Hgf beta [extracellular region]
(R-MMU-1264804)
Hgf [platelet alpha granule lumen]
(R-MMU-139866)
Hgf [platelet alpha granule lumen]
(R-MMU-141764)
Hgf [extracellular region]
(R-MMU-6800218)
Hgf [extracellular region]
(R-MMU-141767)
Hgf [extracellular region]
(R-MMU-56497)
0.558
3
UniProt:P41218 MNDA
3
MNDA [ficolin-1-rich granule lumen]
(R-HSA-6800897)
MNDA [extracellular region]
(R-HSA-6806244)
MNDA [azurophil granule lumen]
(R-HSA-6799237)
0.556
3
UniProt:O95968 SG1D1
0.527
2
UniProt:Q15365 PCBP1
1
PCBP1 [nucleoplasm]
(R-HSA-71919)
0.527
2
UniProt:O15031 PLXB2
0.524
2
UniProt:Q9ULL4 PLXNB3
1
PLXNB3 [plasma membrane]
(R-HSA-416675)
0.524
2
UniProt:Q8TCU6 PREX1
1
PREX1 [cytosol]
(R-HSA-8863083)
0.524
2
UniProt:Q96EY1-2 DNAJA3
0.524
2
UniProt:Q16288 NTRK3
6
NTRK3(32-495) [plasma membrane]
(R-HSA-9603541)
NTRK3(642-839) [cytosol]
(R-HSA-9603540)
NTRK3(496-641) [mitochondrial outer membrane]
(R-HSA-9603557)
NTRK3(496-641) [cytosol]
(R-HSA-9603542)
NTRK3 [plasma membrane]
(R-HSA-6798240)
p-5Y-NTRK3 [plasma membrane]
(R-HSA-9034718)
0.499
2
UniProt:Q86VI4 LAP4B
0.463
3
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