Reactome | FANCL [nucleoplasm]

FANCL [nucleoplasm]

Stable Identifier

R-HSA-419520

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

E3 ubiquitin-protein ligase FANCL, FANCL_HUMAN

Locations in the PathwayBrowser for interactor UniProt:A2RRN7 A2RRN7

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External Reference Information

External Reference

UniProt:Q9NW38 FANCL

Gene Names

FANCL, PHF9

Chain

initiator methionine:, chain:2-375

Reference Genes

BioGPS Gene:55120 FANCL

COSMIC (genes):FANCL FANCL

CTD Gene:55120 FANCL

dbSNP Gene:55120 FANCL

ENSEMBL:ENSG00000115392 FANCL

HGNC:20748 FANCL

KEGG:hsa:55120 FANCL

Monarch:55120 FANCL

NCBI Gene:55120 FANCL

OMIM:608111 FANCL

UCSC:Q9NW38 FANCL

Reference Transcript

Participates

as a component of

as an input of

FA core complex assembles at DNA interstrand crosslinks (ICLs) (Homo sapiens)

Other forms of this molecule

FANCL [cytosol]

Inferred To

Fancl [nucleoplasm] (Mus musculus)

Fancl [nucleoplasm] (Rattus norvegicus)

FANCL [nucleoplasm] (Bos taurus)

FANCL [nucleoplasm] (Canis familiaris)

FANCL [nucleoplasm] (Gallus gallus)

FANCL [nucleoplasm] (Sus scrofa)

fancl [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_001108108.1, NP_060532.2

OpenTargets

ENSG00000115392

ENSEMBL

ENST00000233741, ENSG00000115392, ENST00000402135, ENSP00000385021, ENSP00000233741

GeneCards

FANCL

HPA

ENSG00000115392-FANCL

PRO

Q9NW38

Pharos - Targets

Q9NW38

Orphanet

FANCL

HMDB Protein

HMDBP09291

PDB

4CCG, 3ZQS, 7KZQ, 7KZP, 7KZV, 7KZR, 7KZT, 7KZS

Interactors (50)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NX63 CHCHD3	3	CHCHD3 [mitochondrial intermembrane space] (R-HSA-8874907) 4xHC-CHCHD3 [mitochondrial intermembrane space] (R-HSA-8874910) CHCHD3 (MIC19) [mitochondrial inner membrane] (R-HSA-8949583)	0.718	6
UniProt:O15360 FANCA	2	FANCA [nucleoplasm] (R-HSA-419541) FANCA [cytosol] (R-HSA-420796)	0.597	3
UniProt:P15976-2 GATA1			0.556	3
UniProt:P09016 HOXD4	1	HOXD4 [nucleoplasm] (R-HSA-5617884)	0.556	3
UniProt:Q6NX45 ZNF774	1	ZNF774 [nucleoplasm] (R-HSA-3110232)	0.556	3
UniProt:Q6NVU6 UFSP1			0.556	3
UniProt:Q8IXS7 Q8IXS7			0.556	3
UniProt:Q9BRK4 LZTS2			0.556	3
UniProt:Q9BVG8-5 KIFC3			0.556	3
UniProt:P28799 GRN	2	GRN [azurophil granule lumen] (R-HSA-6799168) GRN [extracellular region] (R-HSA-6806217)	0.556	3
UniProt:Q5W5X9-3 TTC23			0.556	3
UniProt:Q8IUH3 RBM45			0.556	3
UniProt:Q9NZL3 ZNF224	1	ZNF224 [nucleoplasm] (R-HSA-1027352)	0.556	3
UniProt:Q9Y2D8 ADIP			0.556	3
UniProt:Q9BVG8 KIFC3			0.556	3
UniProt:Q6BCY4-2 CYB5R2			0.556	3
UniProt:Q9BQD7 ANKMT			0.556	3
UniProt:Q9UKT9 IKZF3			0.556	3
UniProt:Q9BSH5 HDHD3			0.556	3
UniProt:Q96H20 SNF8	1	SNF8 [cytosol] (R-HSA-917711)	0.556	3
UniProt:A2RRN7 A2RRN7			0.556	3
UniProt:Q5BKX5-3 ACTMAP			0.556	3
UniProt:Q9UDW3 ZMAT5	1	ZMAT5 [nucleoplasm] (R-HSA-6787850)	0.556	3
IntAct:EBI-22384931 CCSB ORF ID			0.556	3
UniProt:Q8IUC1 KRTAP11-1	1	KRTAP11-1 [cytosol] (R-HSA-6810294)	0.556	3
UniProt:Q52LG2 KRTAP13-2	1	KRTAP13-2 [cytosol] (R-HSA-6810274)	0.556	3
UniProt:Q9NRA8 4ET			0.556	3
UniProt:Q9BWG6 SCNM1			0.556	3
UniProt:A8MQ03 CRTP1			0.556	3
UniProt:Q5T4B2 GT253			0.556	3
UniProt:O43307 ARHGEF9	1	ARHGEF9 [cytosol] (R-HSA-195067)	0.556	3
UniProt:A6NJ78-4 METTL15			0.556	3
UniProt:Q3KP44 ANR55			0.556	3
UniProt:Q3LI70 KRTAP19-6	1	KRTAP19-6 [cytosol] (R-HSA-6810286)	0.556	3
UniProt:Q8IYA8 IHO1			0.556	3
UniProt:Q8NF50-2 DOCK8			0.556	3
UniProt:Q9GZU7 CTDS1			0.556	3
UniProt:Q12800 TFCP2			0.556	3
UniProt:Q9P0T4 ZN581			0.556	3
UniProt:P49720 PSMB3	2	PSMB3 [cytosol] (R-HSA-68747) PSMB3 [nucleoplasm] (R-HSA-174341)	0.556	3
UniProt:O95865 DDAH2			0.556	3
UniProt:Q02363 ID2	1	ID2 [nucleoplasm] (R-HSA-452391)	0.556	3
UniProt:Q9Y3C5 RNF11			0.556	3
UniProt:Q6PF18 MORN3			0.556	3
UniProt:Q9UFD9 RIM3A			0.556	3
UniProt:Q13485 SMAD4	20	SMAD4 P356R [cytosol] (R-HSA-3310988) SMAD4 K428T [cytosol] (R-HSA-3311004) SMAD4 D351del [cytosol] (R-HSA-3310974) SMAD4 R361H [cytosol] (R-HSA-3310984) SMAD4 P356L [cytosol] (R-HSA-3310987) SMAD4 A406T [cytosol] (R-HSA-3311003) SMAD4 D351Y [cytosol] (R-HSA-3310970) SMAD4 D351H [cytosol] (R-HSA-3310965) SMAD4 R361C [cytosol] (R-HSA-3310983) SMAD4 D351G [cytosol] (R-HSA-3310967) SMAD4 R515T [cytosol] (R-HSA-3311008) SMAD4 G352* [cytosol] (R-HSA-9678445) SMAD4 S178* [cytosol] (R-HSA-9675630) SMAD4 G477* [cytosol] (R-HSA-9678447) SMAD4 G473* [cytosol] (R-HSA-9678440) SMAD4 S144* [cytosol] (R-HSA-9675625) SMAD4 E538* [cytosol] (R-HSA-9675626) SMAD4 E390* [cytosol] (R-HSA-9675620) SMAD4 S154* [cytosol] (R-HSA-9675621) SMAD4 E330* [cytosol] (R-HSA-9675622)	0.553	6
UniProt:Q86XK7 VSIG1			0.527	2
UniProt:Q15435 PP1R7			0.508	2
UniProt:Q0VG06 FAAP100	2	FAAP100 [nucleoplasm] (R-HSA-419545) FAAP100 [cytosol] (R-HSA-420799)	0.482	2
UniProt:P15056 BRAF	20	BRAF(1-380)-MACF1(600-7388)fusion [cytosol] (R-HSA-6802402) p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol] (R-HSA-6802536) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620) BRAF T244P [cytosol] (R-HSA-9651165)	0.471	2

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