S1P-binding receptors bind S1P

Stable Identifier
R-HSA-419428
Type
Reaction [binding]
Species
Homo sapiens
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Five EDG-encoded receptors can all bind sphingolipid-1-phosphate (S1P), a second messenger implicated in cell survival, cell migration, and inflammation. The five genes encoding the receptors are EDG1, 3, 5, 6 and 8.
EDG1 is a human gene which encodes a GPCR which binds S1P. Hence this receptor is also known as S1PR1 (Hla T, Maciag T, 1990). S1PR1 seems to couple with Gi proteins (Lee MJ et al, 1996).
EDG5 encodes the GPCR known as S1PR2 (An S et al, 2000). This protein participates in S1P-induced cell proliferation, survival, and transcriptional activation, effects mediated by coupling to Gi and Gq proteins (Windh RT et al, 1999).
EDG3 encodes a GPCR known as S1PR3 (Yamaguchi F et al, 1996). This protein contributes to the regulation of angiogenesis and vascular endothelial cell function. These effects are mediated by coupling with Gi, Gq/11 and G12/13 proteins (Windh RT et al, 1999).
EDG6 encodes the GPCR known as S1PR4 (Graler MH et al, 1998). This EDG receptor gene is intronless and is specifically expressed in the lymphoid tissue. It's actions are mediated by coupling with Gi/o proteins to inhibit adenylyl cyclase (Van Brocklyn JR et al, 2000).
EDG8 encodes the GPCR known as S1PR5 (Kothapalli R et al, 2002). Its actions are mediated by coupling with Gi/o proteins to inhibit adenylyl cyclase (Im DS et al, 2000).

Literature References
PubMed ID Title Journal Year
10799507 Characterization of a novel sphingosine 1-phosphate receptor, Edg-8

Im, DS, Heise, CE, Ancellin, N, O'Dowd, BF, Shei, GJ, Heavens, RP, Rigby, MR, Hla, T, Mandala, S, McAllister, G, George, SR, Lynch, KR

J Biol Chem 2000
2160972 An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein-coupled receptors

Hla, T, Maciag, T

J Biol Chem 1990
8878560 Molecular cloning of the novel human G protein-coupled receptor (GPCR) gene mapped on chromosome 9

Yamaguchi, F, Tokuda, M, Hatase, O, Brenner, S

Biochem Biophys Res Commun 1996
10617617 Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5

An, S, Zheng, Y, Bleu, T

J Biol Chem 2000
12427546 Characterization of a human sphingosine-1-phosphate receptor gene (S1P5) and its differential expression in LGL leukemia

Kothapalli, R, Kusmartseva, I, Loughran, TP

Biochim Biophys Acta 2002
10488065 Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins

Windh, RT, Lee, MJ, Hla, T, An, S, Barr, AJ, Manning, DR

J Biol Chem 1999
8626678 The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway

Lee, MJ, Evans, M, Hla, T

J Biol Chem 1996
10753843 Sphingosine-1-phosphate is a ligand for the G protein-coupled receptor EDG-6

Van Brocklyn, JR, Gräler, MH, Bernhardt, G, Hobson, JP, Lipp, M, Spiegel, S

Blood 2000
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