Reactome | S1PR2-5 bind S1P

S1PR2-5 bind S1P

Stable Identifier

R-HSA-419428

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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Five EDG-encoded receptors can all bind sphingolipid-1-phosphate (S1P), a second messenger implicated in cell survival, cell migration, and inflammation. The five genes encoding the receptors are EDG1, 3, 5, 6 and 8.
EDG5 encodes the GPCR known as S1PR2 (An S et al, 2000). This protein participates in S1P-induced cell proliferation, survival, and transcriptional activation, effects mediated by coupling to Gi and Gq proteins (Windh RT et al, 1999).
EDG3 encodes a GPCR known as S1PR3 (Yamaguchi F et al, 1996). This protein contributes to the regulation of angiogenesis and vascular endothelial cell function. These effects are mediated by coupling with Gi, Gq/11 and G12/13 proteins (Windh RT et al, 1999).
EDG6 encodes the GPCR known as S1PR4 (Graler MH et al, 1998). This EDG receptor gene is intronless and is specifically expressed in the lymphoid tissue. It's actions are mediated by coupling with Gi/o proteins to inhibit adenylyl cyclase (Van Brocklyn JR et al, 2000).
EDG8 encodes the GPCR known as S1PR5 (Kothapalli R et al, 2002). Its actions are mediated by coupling with Gi/o proteins to inhibit adenylyl cyclase (Im DS et al, 2000).
EDG1 which encodes S1PR1 is annotated in a separte reaction to allow therapeutic interaction.

Literature References

PubMed ID	Title	Journal	Year
2160972	An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein-coupled receptors Hla, T, Maciag, T	J Biol Chem	1990
10799507	Characterization of a novel sphingosine 1-phosphate receptor, Edg-8 Im, DS, Heise, CE, Ancellin, N, O'Dowd, BF, Shei, GJ, Heavens, RP, Rigby, MR, Hla, T, Mandala, S, McAllister, G, George, SR, Lynch, KR	J Biol Chem	2000
8878560	Molecular cloning of the novel human G protein-coupled receptor (GPCR) gene mapped on chromosome 9 Yamaguchi, F, Tokuda, M, Hatase, O, Brenner, S	Biochem Biophys Res Commun	1996
10617617	Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5 An, S, Zheng, Y, Bleu, T	J Biol Chem	2000
12427546	Characterization of a human sphingosine-1-phosphate receptor gene (S1P5) and its differential expression in LGL leukemia Kothapalli, R, Kusmartseva, I, Loughran, TP	Biochim Biophys Acta	2002
10488065	Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins Windh, RT, Lee, MJ, Hla, T, An, S, Barr, AJ, Manning, DR	J Biol Chem	1999
8626678	The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway Lee, MJ, Evans, M, Hla, T	J Biol Chem	1996
10753843	Sphingosine-1-phosphate is a ligand for the G protein-coupled receptor EDG-6 Van Brocklyn, JR, Gräler, MH, Bernhardt, G, Hobson, JP, Lipp, M, Spiegel, S	Blood	2000