Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
S1PR5 [plasma membrane]
Stable Identifier
R-HSA-419420
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Sphingosine 1-phosphate receptor 5, S1PR5_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
S1PR2-5:S1P [plasma membrane] (Homo sapiens)
S1PR2-5 [plasma membrane] (Homo sapiens)
S1PR5 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
S1PR2-5:S1P [plasma membrane] (Homo sapiens)
S1PR2-5 [plasma membrane] (Homo sapiens)
S1PR5 [plasma membrane] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
S1PR2-5:S1P [plasma membrane] (Homo sapiens)
S1PR2-5 [plasma membrane] (Homo sapiens)
S1PR5 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
S1PR2-5:S1P [plasma membrane] (Homo sapiens)
S1PR2-5 [plasma membrane] (Homo sapiens)
S1PR5 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
S1PR2-5:S1P [plasma membrane] (Homo sapiens)
S1PR2-5 [plasma membrane] (Homo sapiens)
S1PR5 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
S1PR2-5:S1P [plasma membrane] (Homo sapiens)
S1PR2-5 [plasma membrane] (Homo sapiens)
S1PR5 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Lysosphingolipid and LPA receptors (Homo sapiens)
S1PR2-5 bind S1P (Homo sapiens)
S1PR2-5 [plasma membrane] (Homo sapiens)
S1PR5 [plasma membrane] (Homo sapiens)
S1PR2-5:S1P [plasma membrane] (Homo sapiens)
S1PR2-5 [plasma membrane] (Homo sapiens)
S1PR5 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9H228 S1PR5
Gene Names
S1PR5, EDG8
Chain
chain:1-398
Reference Genes
BioGPS Gene:53637 S1PR5
COSMIC (genes):S1PR5 S1PR5
CTD Gene:53637 S1PR5
dbSNP Gene:53637 S1PR5
ENSEMBL:ENSG00000180739 S1PR5
ENSEMBL_homo_sapiens_GENE:ENSG00000180739.15 S1PR5
HGNC:14299 S1PR5
KEGG Gene (Homo sapiens):53637 S1PR5
Monarch:53637 S1PR5
NCBI Gene:53637 S1PR5
OMIM:605146 S1PR5
UCSC:Q9H228 S1PR5
Reference Transcript
RefSeq:NM_001166215.1 S1PR5
RefSeq:NM_030760.4 S1PR5
Other Identifiers
11752664_a_at
16868752
221417_PM_x_at
221417_x_at
230464_PM_at
230464_at
233743_PM_x_at
233743_x_at
3850387
3850389
3850391
3850393
3850395
3850397
3850399
3850401
3850403
3850405
3850407
3850408
53620_at
53637
8034043
A_23_P107744
A_23_P107750
GE87072
GO:0003376
GO:0004930
GO:0005515
GO:0005737
GO:0005886
GO:0007165
GO:0007186
GO:0007189
GO:0016020
GO:0019222
GO:0023052
GO:0030154
GO:0038036
GO:0045664
GO:0048856
GO:0060089
HMNXSV003050432
Hs.46668.0.A1_3p_at
ILMN_2073184
PH_hs_0029690
TC19001167.hg
g13540516_3p_s_at
Participates
as a member of
S1PR2-5 [plasma membrane] (Homo sapiens)
Inferred To
S1pr5 [plasma membrane]
(Mus musculus)
S1pr5 [plasma membrane]
(Rattus norvegicus)
Homologues of S1PR5 [plasma membrane]
(Sus scrofa)
S1PR5 [plasma membrane]
(Bos taurus)
S1PR5 [plasma membrane]
(Canis familiaris)
S1PR5 [plasma membrane]
(Sus scrofa)
zgc:158362 [plasma membrane]
(Danio rerio)
s1pr5 [plasma membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_110387.1
,
NP_001159687.1
ZINC - World Drugs
S1PR5_HUMAN
Guide to Pharmacology - Targets
279
OpenTargets
ENSG00000180739
ZINC - FDA approved
S1PR5_HUMAN
ZINC - Substances
S1PR5_HUMAN
ZINC target
Q9H228
ZINC - Biogenic
S1PR5_HUMAN
PRO
Q9H228
PDB
7YXA
,
7EW1
ZINC - Investigational
S1PR5_HUMAN
ZINC - Metabolites
S1PR5_HUMAN
GeneCards
Q9H228
HPA
ENSG00000180739-S1PR5
Ensembl
ENSP00000328472
,
ENSG00000180739
,
ENST00000439028
,
ENSP00000416915
,
ENST00000333430
Pharos - Targets
Q9H228
ZINC - Predictions - Purchasable
S1PR5_HUMAN
HMDB Protein
HMDBP02770
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text