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S1PR4 [plasma membrane]
Stable Identifier
R-HSA-419347
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Sphingosine 1-phosphate receptor 4, S1PR4_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
S1PR2-5:S1P [plasma membrane] (Homo sapiens)
S1PR2-5 [plasma membrane] (Homo sapiens)
S1PR4 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
S1PR2-5:S1P [plasma membrane] (Homo sapiens)
S1PR2-5 [plasma membrane] (Homo sapiens)
S1PR4 [plasma membrane] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
S1PR2-5:S1P [plasma membrane] (Homo sapiens)
S1PR2-5 [plasma membrane] (Homo sapiens)
S1PR4 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
S1PR2-5:S1P [plasma membrane] (Homo sapiens)
S1PR2-5 [plasma membrane] (Homo sapiens)
S1PR4 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
S1PR2-5:S1P [plasma membrane] (Homo sapiens)
S1PR2-5 [plasma membrane] (Homo sapiens)
S1PR4 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
S1PR2-5:S1P [plasma membrane] (Homo sapiens)
S1PR2-5 [plasma membrane] (Homo sapiens)
S1PR4 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Lysosphingolipid and LPA receptors (Homo sapiens)
S1PR2-5 bind S1P (Homo sapiens)
S1PR2-5 [plasma membrane] (Homo sapiens)
S1PR4 [plasma membrane] (Homo sapiens)
S1PR2-5:S1P [plasma membrane] (Homo sapiens)
S1PR2-5 [plasma membrane] (Homo sapiens)
S1PR4 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O95977 S1PR4
Gene Names
S1PR4, EDG6
Chain
chain:1-384
Reference Genes
BioGPS Gene:8698 S1PR4
COSMIC (genes):S1PR4 S1PR4
CTD Gene:8698 S1PR4
dbSNP Gene:8698 S1PR4
ENSEMBL:ENSG00000125910 S1PR4
ENSEMBL:ENSG00000125910.6 S1PR4
HGNC:3170 S1PR4
KEGG Gene (Homo sapiens):8698 S1PR4
Monarch:8698 S1PR4
NCBI Gene:8698 S1PR4
OMIM:603751 S1PR4
UCSC:O95977 S1PR4
Reference Transcript
RefSeq:NM_003775.3 S1PR4
Other Identifiers
11730994_at
16856906
206437_PM_at
206437_at
33602_at
3816830
3816831
3816832
3816833
8024582
8698
ADDON002883.hg
A_14_P131141
A_23_P119502
A_33_P3281273
GE55127
GO:0002376
GO:0003376
GO:0004930
GO:0005515
GO:0005739
GO:0005886
GO:0006955
GO:0007165
GO:0007186
GO:0007189
GO:0007202
GO:0007204
GO:0008289
GO:0016020
GO:0023052
GO:0038036
GO:0043226
GO:0060089
HMNXSV003040688
ILMN_1784737
PH_hs_0009718
PH_hs_0039994
TC19000066.hg
g4503458_3p_at
Participates
as a member of
S1PR2-5 [plasma membrane] (Homo sapiens)
Inferred To
S1PR4 [plasma membrane]
(Bos taurus)
S1PR4 [plasma membrane]
(Canis familiaris)
S1PR4 [plasma membrane]
(Gallus gallus)
S1PR4 [plasma membrane]
(Sus scrofa)
s1pr4 [plasma membrane]
(Xenopus tropicalis)
edg6 [plasma membrane]
(Danio rerio)
S1pr4 [plasma membrane]
(Mus musculus)
S1pr4 [plasma membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_003766.1
ZINC - World Drugs
S1PR4_HUMAN
Guide to Pharmacology - Targets
278
OpenTargets
ENSG00000125910
ZINC - FDA approved
S1PR4_HUMAN
ZINC - Substances
S1PR4_HUMAN
ZINC target
O95977
ZINC - Biogenic
S1PR4_HUMAN
PRO
O95977
PDB
2DCO
ZINC - Investigational
S1PR4_HUMAN
ZINC - Metabolites
S1PR4_HUMAN
HPA
ENSG00000125910-S1PR4
GeneCards
O95977
Ensembl
ENST00000246115
,
ENSP00000246115
,
ENSG00000125910
Pharos - Targets
O95977
ZINC - Predictions - Purchasable
S1PR4_HUMAN
HMDB Protein
HMDBP02561
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