Melatonin receptors can bind melatonin

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R-HSA-419334
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Reaction [binding]
Species
Homo sapiens
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Melatonin (N-acetyl-5-methoxytryptamine) is a natural hormone produced by the pineal gland that is involved in the regulation of circadian rhythms. These actions are mediated by melatonin receptors. Melatonin can also function as a powerful antioxidant in the protection of nuclear and mitochondrial DNA.There are two melatonin receptors in humans, MT1 (Mel1a, MTNR1A) and MT2 (Mel1b, MTNR1B). Their actions are mediated by coupling with the G protein alpha i/o subunits to inhibit adenylyl cyclase (Reppert SM et al, 1994: Reppert SM et al, 1995).

Literature References
PubMed ID Title Journal Year
7568007 Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor

Reppert, SM, Godson, C, Mahle, CD, Weaver, DR, Slaugenhaupt, SA, Gusella, JF

Proc Natl Acad Sci U S A 1995
7946354 Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses

Reppert, SM, Weaver, DR, Ebisawa, T

Neuron 1994
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