Reactome | Melatonin receptors can bind melatonin

Melatonin receptors can bind melatonin

Stable Identifier

R-HSA-419334

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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Melatonin (N-acetyl-5-methoxytryptamine) is a natural hormone produced by the pineal gland that is involved in the regulation of circadian rhythms. These actions are mediated by melatonin receptors. Melatonin can also function as a powerful antioxidant in the protection of nuclear and mitochondrial DNA.There are two melatonin receptors in humans, MT1 (Mel1a, MTNR1A) and MT2 (Mel1b, MTNR1B). Their actions are mediated by coupling with the G protein alpha i/o subunits to inhibit adenylyl cyclase (Reppert SM et al, 1994: Reppert SM et al, 1995).

Literature References

PubMed ID	Title	Journal	Year
7946354	Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses Reppert, SM, Ebisawa, T, Weaver, DR	Neuron	1994
7568007	Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor Gusella, JF, Slaugenhaupt, SA, Reppert, SM, Mahle, CD, Godson, C, Weaver, DR	Proc Natl Acad Sci U S A	1995