Reactome | Transhomodimerization of Nectins

Transhomodimerization of Nectins

Stable Identifier

R-HSA-419011

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cell junction

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Nectins are Ca(2+)-independent cell adhesion molecules which interact homophilically and heterophilically in trans to form cell-cell adhesions (reviewed in (Sakisaka et al., 2007; Takai et al., 2008). Each nectin first forms homo-cis-dimers and then homo- or hetero-trans-dimers through the extracellular region, causing cell–cell adhesion. The Nectin protein family is made up of four members, nectin-1, -2, -3, and -4, all of which have an extracellular region with three Ig-like loops, a single transmembrane region, and a cytoplasmic tail region.

Literature References

PubMed ID	Title	Journal	Year
10225955	Nectin/PRR: an immunoglobulin-like cell adhesion molecule recruited to cadherin-based adherens junctions through interaction with Afadin, a PDZ domain-containing protein Takahashi, K, Nakanishi, H, Miyahara, M, Mandai, K, Satoh, K, Satoh, A, Nishioka, H, Aoki, J, Nomoto, A, Mizoguchi, A, Takai, Y	J Cell Biol	1999
9845526	The human poliovirus receptor related 2 protein is a new hematopoietic/endothelial homophilic adhesion molecule Lopez, M, Aoubala, M, Jordier, F, Isnardon, D, Gomez, S, Dubreuil, P	Blood	1998