Nectins are Ca(2+)-independent cell adhesion molecules which interact homophilically and heterophilically in trans to form cell-cell adhesions (reviewed in (Sakisaka et al., 2007; Takai et al., 2008). Each nectin first forms homo-cis-dimers and then homo- or hetero-trans-dimers through the extracellular region, causing cell–cell adhesion. The Nectin protein family is made up of four members, nectin-1, -2, -3, and -4, all of which have an extracellular region with three Ig-like loops, a single transmembrane region, and a cytoplasmic tail region.
Aoki, J, Takai, Y, Nishioka, H, Nakanishi, H, Satoh, K, Mizoguchi, A, Miyahara, M, Mandai, K, Takahashi, K, Satoh, A, Nomoto, A
Gomez, S, Dubreuil, P, Isnardon, D, Aoubala, M, Lopez, M, Jordier, F
© 2022 Reactome
