Reactome | Transhomodimerization of Nectins

Transhomodimerization of Nectins

Stable Identifier

R-HSA-419011

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cell junction

ReviewStatus

5/5

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Nectins are Ca(2+)-independent cell adhesion molecules which interact homophilically and heterophilically in trans to form cell-cell adhesions (reviewed in (Sakisaka et al., 2007; Takai et al., 2008). Each nectin first forms homo-cis-dimers and then homo- or hetero-trans-dimers through the extracellular region, causing cell–cell adhesion. The Nectin protein family is made up of four members, nectin-1, -2, -3, and -4, all of which have an extracellular region with three Ig-like loops, a single transmembrane region, and a cytoplasmic tail region.

Literature References

PubMed ID	Title	Journal	Year
10225955	Nectin/PRR: an immunoglobulin-like cell adhesion molecule recruited to cadherin-based adherens junctions through interaction with Afadin, a PDZ domain-containing protein Aoki, J, Takai, Y, Nishioka, H, Nakanishi, H, Satoh, K, Mizoguchi, A, Miyahara, M, Mandai, K, Takahashi, K, Satoh, A, Nomoto, A	J Cell Biol	1999
9845526	The human poliovirus receptor related 2 protein is a new hematopoietic/endothelial homophilic adhesion molecule Gomez, S, Dubreuil, P, Isnardon, D, Aoubala, M, Lopez, M, Jordier, F	Blood	1998