PITPalpha binds DCC

Stable Identifier
R-HSA-418866
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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DCC interacts directly with PITPalpha and this interaction is enhanced in the presence of Netrin-1. The interaction of DCC with PITPalpha requires the carboxy-terminal dmain of both the proteins. PITPalpha signaling pathway is important for netrin-1 mediated axon outgrowth. Netrin-1 activates PITPalpha to regulate local phosphoinositide (PI) synthesis, which is important for PI3K dependent neurite elongation.

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