Shp2 binds pUnc5C

Stable Identifier
R-HSA-418863
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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PTPN11 (SHP2) is recruited to the phosphorylated UNC5C receptor after netrin-1 (NTN1) stimulation, in a fashion that requires binding of the PTPN11 SH2 domains to the Tyr568 (Y568) phosphorylated motif. The functional significance of the UNC5C- PTPN11 interaction has not been reported. PTPN11 might negatively regulate tyrosine phosphorylation of UNC5C receptor, facilitating resensitization of the receptor to the netrin-1 signal.

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