Src activation following P2Y purinoceptor activation

Stable Identifier
R-HSA-418662
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Src activation following P2Y purinoceptor activation
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Activation of Src lies selectively downstream of P2Y1, but not P2Y12. The precise mechanism is not known, but Src regulation of the PI3K component of the intracellular calcium response downstream of P2Y12 represents a point of reciprocal cross-talk between P2Y1 and P2Y12 receptors.
Literature References
PubMed ID Title Journal Year
15187029 Reciprocal cross-talk between P2Y1 and P2Y12 receptors at the level of calcium signaling in human platelets

Poole, AW, Mundell, SJ, Hardy, AR, Jones, ML

Blood 2004
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Output
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Orthologous Events
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Src activation following P2Y purinoceptor activation (Sus scrofa)
Authored
Akkerman, JW  (2009-06-03)
Reviewed
Harper, MT  (2009-11-02)
Poole, AW  (2009-11-02)
Jones, ML  (2009-11-02)
Created
Jupe, S  (2009-04-27)
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