Reactome | cAMP degradation by Phosphodiesterases

cAMP degradation by Phosphodiesterases

Stable Identifier

R-HSA-418553

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

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Cyclic nucleotide phosphodiesterases (PDEs) are a large family of enzymes that regulate signal transduction by the second messenger molecules cAMP and cGMP. Some PDEs are cAMP selective (PDE4, 7 and 8), some cGMP selective (PDE5, 6 and 9) while others can hydrolyse cAMP and cGMP (PDE1, 2, 3, 10 and 11). PDEs are important as drug targets: Sildenafil (Viagra) is an inhibitor of PDE5; Cilostazol (Pletal) inhibits PDE3, increasing the flexibility of erythrocytes.

Literature References

PubMed ID	Title	Journal	Year
15769620	Cyclic nucleotide phosphodiesterase-mediated integration of cGMP and cAMP signaling in cells of the cardiovascular system Maurice, DH	Front Biosci	2005
	The Cell - A Molecular Approach Cooper, GM, Hausman, RE		2002