Reactome | PDE11A [cytosol]

PDE11A [cytosol]

Stable Identifier

R-HSA-418539

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Phosphodiesterase 11A, Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A, PDE11_HUMAN

Locations in the PathwayBrowser

Expand all

Hemostasis (Homo sapiens)

- Platelet homeostasis (Homo sapiens)
  - Nitric oxide stimulates guanylate cyclase (Homo sapiens)
    - cGMP effects (Homo sapiens)
      - cGMP is degraded by PDEs (Homo sapiens)
        
        cGMP phosphodiesterases [cytosol] (Homo sapiens)
        
        Phosphodiesterases, dual (cAMP, cGMP) activity [cytosol] (Homo sapiens)
        
        PDE11A [cytosol] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (s) signalling events (Homo sapiens)
      - cAMP degradation by Phosphodiesterases (Homo sapiens)
        
        cAMP PDEs [cytosol] (Homo sapiens)
        
        Phosphodiesterases, dual (cAMP, cGMP) activity [cytosol] (Homo sapiens)
        
        PDE11A [cytosol] (Homo sapiens)

General

Can hydrolyze both cAMP and cGMP

External Reference Information

External Reference

UniProt:Q9HCR9 PDE11A

Gene Names

PDE11A

Chain

chain:1-933

Reference Genes

BioGPS Gene:50940 PDE11A

COSMIC (genes):PDE11A PDE11A

CTD Gene:50940 PDE11A

dbSNP Gene:50940 PDE11A

ENSEMBL:ENSG00000128655 PDE11A

HGNC:8773 PDE11A

KEGG:hsa:50940 PDE11A

Monarch:50940 PDE11A

NCBI Gene:50940 PDE11A

OMIM:604961 PDE11A

UCSC:Q9HCR9 PDE11A

Reference Transcript

Other Identifiers

11731999_a_at

11732000_a_at

11732001_a_at

11742250_a_at

11755864_a_at

16905521

16905528

221110_PM_x_at

221110_x_at

224223_PM_s_at

224223_s_at

224224_PM_s_at

224224_s_at

237248_PM_at

237248_at

2588968

2588970

2589013

2589014

2589016

2589018

2589019

2589020

2589021

2589022

2589023

2589024

2589025

2589026

2589027

2589028

2589038

2589039

2589043

2589044

2589047

2589049

2589052

2589055

2589058

2589064

2589065

2589090

2589095

2589096

2589097

2589101

2589102

2589103

2589105

2589108

2589111

2589115

2589116

2589117

2589118

2589119

2589120

2589121

2589126

2589136

2589137

2589140

2589142

2589143

46836_at

50940

8056999

8057004

A_23_P394367

A_24_P43144

A_32_P116857

A_32_P228037

GE82160

GO:0003824

GO:0004112

GO:0004114

GO:0004115

GO:0004118

GO:0005515

GO:0005575

GO:0005737

GO:0005829

GO:0007165

GO:0008081

GO:0010754

GO:0016787

GO:0019933

GO:0030553

GO:0043951

GO:0046872

GO:0047555

HMNXSV003030964

HMNXSV003056521

Hs.47208.0.A1_3p_at

ILMN_1813325

ILMN_2278246

ILMN_2364600

PH_hs_0003356

PH_hs_0024743

TC02002570.hg

TC02004723.hg

g10716053_3p_a_at

g8393925_3p_a_at

Participates

as a member of

Phosphodiesterases, dual (cAMP, cGMP) activity [cytosol] (Homo sapiens)

Inferred To

PDE11A [cytosol] (Bos taurus)

PDE11A [cytosol] (Canis familiaris)

PDE11A [cytosol] (Gallus gallus)

PDE11A [cytosol] (Mus musculus)

PDE11A [cytosol] (Rattus norvegicus)

PDE11A [cytosol] (Sus scrofa)

Cross References

Guide to Pharmacology - Targets

1311

ENSEMBL

ENST00000389683, ENSP00000386539, ENST00000286063, ENSP00000286063, ENSP00000374333, ENSG00000128655, ENSP00000351232, ENST00000409504, ENST00000358450

OpenTargets

ENSG00000128655

ZINC - FDA approved

PDE11_HUMAN

ZINC - Substances

PDE11_HUMAN

ZINC target

Q9HCR9

PRO

Q9HCR9

IntEnz

3.1.4.35, 3.1.4.53

GeneCards

PDE11A

HPA

ENSG00000128655-PDE11A

Pharos - Targets

Q9HCR9

Orphanet

PDE11A

ZINC - Predictions - Purchasable

PDE11_HUMAN

HMDB Protein

HMDBP04379