Reactome | PDE9A [cytosol]

PDE9A [cytosol]

Stable Identifier

R-HSA-418533

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Phosphodiesterase 9A, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, PDE9A_HUMAN

Locations in the PathwayBrowser

Expand all

Hemostasis (Homo sapiens)

- Platelet homeostasis (Homo sapiens)
  - Nitric oxide stimulates guanylate cyclase (Homo sapiens)
    - cGMP effects (Homo sapiens)
      - cGMP is degraded by PDEs (Homo sapiens)
        
        cGMP phosphodiesterases [cytosol] (Homo sapiens)
        
        Phosphodiesterases, cyclic GMP-selective [cytosol] (Homo sapiens)
        
        PDE9A [cytosol] (Homo sapiens)

General

cGMP selective hydrolase

External Reference Information

External Reference

UniProt:O76083 PDE9A

Gene Names

PDE9A

Chain

chain:1-593

Reference Genes

BioGPS Gene:5152 PDE9A

COSMIC (genes):PDE9A PDE9A

CTD Gene:5152 PDE9A

dbSNP Gene:5152 PDE9A

ENSEMBL:ENSG00000160191.18 PDE9A

HGNC:8795 PDE9A

KEGG Gene (Homo sapiens):5152 PDE9A

Monarch:5152 PDE9A

NCBI Gene:5152 PDE9A

OMIM:602973 PDE9A

UCSC:O76083 PDE9A

Reference Transcript

Other Identifiers

0005220398

11738092_a_at

16923239

205593_PM_s_at

205593_s_at

33709_at

3922794

3922795

3922819

3922820

3922826

3922833

3922841

3922842

3922843

3922847

3922848

3922854

3922856

3922862

3922864

3922867

3922868

3922871

3922872

3922874

3922877

3922879

3922883

3922886

3922887

3922888

5152

8068833

A_23_P29096

GE53429

GO:0003012

GO:0004114

GO:0005515

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005783

GO:0005794

GO:0005829

GO:0005886

GO:0007165

GO:0008081

GO:0010613

GO:0016020

GO:0016787

GO:0019934

GO:0023052

GO:0032587

GO:0042383

GO:0042802

GO:0042995

GO:0043204

GO:0043226

GO:0046068

GO:0046069

GO:0046872

GO:0047555

GO:0048471

GO:0055086

GO:1901135

HMNXSV003013127

HMNXSV003049581

ILMN_1683063

ILMN_1767176

ILMN_2306540

TC21000204.hg

g4505674_3p_a_at

Participates

as a member of

Phosphodiesterases, cyclic GMP-selective [cytosol] (Homo sapiens)

Inferred To

PDE9A [cytosol] (Bos taurus)

PDE9A [cytosol] (Canis familiaris)

PDE9A [cytosol] (Danio rerio)

PDE9A [cytosol] (Dictyostelium discoideum)

PDE9A [cytosol] (Gallus gallus)

PDE9A [cytosol] (Mus musculus)

PDE9A [cytosol] (Plasmodium falciparum)

PDE9A [cytosol] (Rattus norvegicus)

PDE9A [cytosol] (Sus scrofa)

PDE9A [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001001572.1, NP_001001580.1, NP_001001575.1, XP_016883855.1, NP_001001571.1, NP_001001578.1, NP_001001584.1, NP_001001569.1, NP_001001583.1, NP_001001577.1, NP_001001582.1, NP_001001574.1, NP_001001570.1, NP_001001573.1, NP_001302462.1, NP_001001579.1, NP_001001568.1, NP_001001567.1, NP_002597.1, NP_001001585.1, NP_001001576.1, NP_001001581.1

ZINC - World Drugs

PDE9A_HUMAN

Guide to Pharmacology - Targets

1309

OpenTargets

ENSG00000160191

ZINC - FDA approved

PDE9A_HUMAN

ZINC - Substances

PDE9A_HUMAN

ZINC target

O76083

PRO

O76083

PDB

6LZZ, 3QI4, 4E90, 3DY8, 4Y87, 7F0I, 3DYL, 3JSI, 4G2L, 4Y86, 3DYS, 3QI3, 3JSW, 2YY2, 4GH6, 4Y8C, 3N3Z, 6A3N, 3K3H, 4G2J, 3DYQ, 3K3E, 3DYN, 2HD1

ZINC - Investigational

PDE9A_HUMAN

IntEnz

3.1.4.35

GeneCards

O76083

HPA

ENSG00000160191-PDE9A

Ensembl

ENST00000291539, ENST00000328862, ENSP00000291539, ENST00000398236, ENST00000380328, ENSP00000381281, ENST00000398234, ENST00000335440, ENSP00000381283, ENST00000398232, ENSP00000335242, ENSP00000335365, ENSP00000381280, ENST00000398225, ENST00000398224, ENSP00000369685, ENST00000398227, ENSP00000381289, ENSP00000328699, ENST00000335512, ENST00000398229, ENSP00000381285, ENSP00000381291, ENSP00000381287, ENST00000349112, ENSP00000344730, ENSG00000160191

Pharos - Targets

O76083

ZINC - Predictions - Purchasable

PDE9A_HUMAN

HMDB Protein

HMDBP00616

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q49AN0 CRY2	4	p-S-CRY2 [cytosol] (R-HSA-400305) p-S-CRY2 [nucleoplasm] (R-HSA-400328) CRY2 [cytosol] (R-HSA-400255) Ub-p-S-CRY2 [nucleoplasm] (R-HSA-517935)	0.556	3

Cite Us!