Reactome | PDE9A [cytosol]

PDE9A [cytosol]

Stable Identifier

R-HSA-418533

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Phosphodiesterase 9A, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, PDE9A_HUMAN

Locations in the PathwayBrowser

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Hemostasis (Homo sapiens)

- Platelet homeostasis (Homo sapiens)
  - Nitric oxide stimulates guanylate cyclase (Homo sapiens)
    - cGMP effects (Homo sapiens)
      - cGMP is degraded by PDEs (Homo sapiens)
        
        cGMP phosphodiesterases [cytosol] (Homo sapiens)
        
        Phosphodiesterases, cyclic GMP-selective [cytosol] (Homo sapiens)
        
        PDE9A [cytosol] (Homo sapiens)

General

cGMP selective hydrolase

External Reference Information

External Reference

UniProt:O76083 PDE9A

Gene Names

PDE9A

Chain

chain:1-593

Reference Genes

BioGPS Gene:5152 PDE9A

COSMIC (genes):PDE9A PDE9A

CTD Gene:5152 PDE9A

dbSNP Gene:5152 PDE9A

ENSEMBL:ENSG00000160191 PDE9A

HGNC:8795 PDE9A

KEGG:hsa:5152 PDE9A

Monarch:5152 PDE9A

NCBI Gene:5152 PDE9A

OMIM:602973 PDE9A

UCSC:O76083 PDE9A

Reference Transcript

Participates

as a member of

Phosphodiesterases, cyclic GMP-selective [cytosol] (Homo sapiens)

Inferred To

PDE9A [cytosol] (Bos taurus)

PDE9A [cytosol] (Canis familiaris)

PDE9A [cytosol] (Gallus gallus)

PDE9A [cytosol] (Mus musculus)

PDE9A [cytosol] (Rattus norvegicus)

PDE9A [cytosol] (Saccharomyces cerevisiae)

PDE9A [cytosol] (Sus scrofa)

PDE9A [cytosol] (Xenopus tropicalis)

Cross References

Guide to Pharmacology - Targets

1309

OpenTargets

ENSG00000160191

ENSEMBL

ENST00000398224, ENST00000349112, ENSP00000369685, ENSP00000381291, ENSP00000291539, ENSP00000328699, ENST00000328862, ENST00000398236, ENST00000398232, ENSP00000381289, ENST00000398234, ENST00000335512, ENSP00000335365, ENSP00000335242, ENSP00000344730, ENST00000398229, ENSP00000381280, ENSP00000381281, ENSP00000381283, ENST00000380328, ENST00000291539, ENSP00000381285, ENST00000398225, ENST00000398227, ENSG00000160191, ENSP00000381287, ENST00000335440

ZINC - FDA approved

PDE9A_HUMAN

ZINC - Substances

PDE9A_HUMAN

ZINC target

O76083

PRO

O76083

PDB

2YY2, 3K3H, 4G2L, 3DY8, 4Y8C, 4G2J, 4Y87, 3K3E, 4Y86, 4E90, 6LZZ, 3JSI, 3DYN, 3DYS, 3DYL, 3DYQ, 3N3Z, 3QI4, 3QI3, 2HD1, 4GH6, 7F0I, 3JSW, 6A3N, 8BPY

ZINC - Investigational

PDE9A_HUMAN

IntEnz

3.1.4.35

HPA

ENSG00000160191-PDE9A

GeneCards

PDE9A

Pharos - Targets

O76083

ZINC - Predictions - Purchasable

PDE9A_HUMAN

HMDB Protein

HMDBP00616

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q7Z3S9 NOTCH2NLA	3	NOTCH2NLA [extracellular region] (R-HSA-9908935) NOTCH2NLA(1-?) [extracellular region] (R-HSA-9911493) NOTCH2NLA(?-236) [extracellular region] (R-HSA-9911490)	0.666	4
UniProt:Q49AN0 CRY2	5	CRY2 [cytosol] (R-HSA-400255) p-S-CRY2 [nucleoplasm] (R-HSA-400328) p-S-CRY2 [cytosol] (R-HSA-400305) K48polyUb-K126,p-S-CRY2 [cytosol] (R-HSA-9932882) K48polyUb-K,p-S-CRY2 [nucleoplasm] (R-HSA-517935)	0.556	3

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