Reactome | PDE9A [cytosol]

PDE9A [cytosol]

Stable Identifier

R-HSA-418533

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Phosphodiesterase 9A, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, PDE9A_HUMAN

Locations in the PathwayBrowser

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Hemostasis (Homo sapiens)

- Platelet homeostasis (Homo sapiens)
  - Nitric oxide stimulates guanylate cyclase (Homo sapiens)
    - cGMP effects (Homo sapiens)
      - cGMP is degraded by PDEs (Homo sapiens)
        
        cGMP phosphodiesterases [cytosol] (Homo sapiens)
        
        Phosphodiesterases, cyclic GMP-selective [cytosol] (Homo sapiens)
        
        PDE9A [cytosol] (Homo sapiens)

General

cGMP selective hydrolase

External Reference Information

External Reference

UniProt:O76083 PDE9A

Gene Names

PDE9A

Chain

chain:1-593

Reference Genes

BioGPS Gene:5152 PDE9A

COSMIC (genes):PDE9A PDE9A

CTD Gene:5152 PDE9A

dbSNP Gene:5152 PDE9A

ENSEMBL:ENSG00000160191 PDE9A

HGNC:8795 PDE9A

KEGG Gene (Homo sapiens):5152 PDE9A

Monarch:5152 PDE9A

NCBI Gene:5152 PDE9A

OMIM:602973 PDE9A

UCSC:O76083 PDE9A

Reference Transcript

Other Identifiers

0005220398

11738092_a_at

16923239

205593_s_at

33709_at

3922794

3922795

3922819

3922820

3922826

3922833

3922841

3922842

3922843

3922847

3922848

3922854

3922856

3922862

3922864

3922867

3922868

3922871

3922872

3922874

3922877

3922879

3922883

3922886

3922887

3922888

5152

8068833

A_23_P29096

GE53429

GO:0003674

GO:0004114

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005783

GO:0005794

GO:0005829

GO:0005886

GO:0007165

GO:0008081

GO:0008150

GO:0009056

GO:0009058

GO:0010613

GO:0016020

GO:0016787

GO:0019934

GO:0032587

GO:0034641

GO:0034655

GO:0042383

GO:0042995

GO:0043167

GO:0043204

GO:0043226

GO:0044281

GO:0046068

GO:0046069

GO:0046872

GO:0047555

GO:0048471

ILMN_1683063

ILMN_1767176

ILMN_2306540

TC21000204.hg

g4505674_3p_a_at

Participant Of

hasMember

Phosphodiesterases, cyclic GMP-selective [cytosol]

Inferred To

PDE9A [cytosol] (Bos taurus)

PDE9A [cytosol] (Canis familiaris)

PDE9A [cytosol] (Gallus gallus)

PDE9A [cytosol] (Sus scrofa)

Pde9a [cytosol] (Mus musculus)

Pde9a [cytosol] (Rattus norvegicus)

git2 [cytosol] (Xenopus tropicalis)

pde9a [cytosol] (Danio rerio)

Cross References

RefSeq

NP_001001571.1, NP_001001580.1, NP_001001583.1, NP_001001579.1, NP_001001576.1, NP_001001575.1, NP_001001567.1, NP_001001584.1, NP_001001572.1, NP_001001568.1, NP_001001585.1, NP_001001582.1, NP_002597.1, NP_001001570.1, NP_001001581.1, XP_016883855.1, NP_001001574.1, NP_001001578.1, NP_001001573.1, NP_001001577.1, NP_001302462.1, NP_001001569.1

ZINC - World Drugs

PDE9A_HUMAN

OpenTargets

ENSG00000160191

ZINC - FDA approved

PDE9A_HUMAN

ZINC - Substances

PDE9A_HUMAN

ZINC target

O76083

PRO

O76083

PDB

3K3E, 3DYN, 2HD1, 3QI4, 4G2L, 2YY2, 3DY8, 3QI3, 3JSI, 3DYL, 4Y86, 4Y87, 4GH6, 3DYS, 3JSW, 3K3H, 4G2J, 6A3N, 3N3Z, 4E90, 3DYQ, 4Y8C

ZINC - Investigational

PDE9A_HUMAN

IntEnz

3.1.4.35

GeneCards

O76083

HPA

ENSG00000160191-PDE9A

Ensembl

ENSP00000381280, ENST00000349112, ENSP00000381281, ENSP00000381283, ENST00000335440, ENSP00000291539, ENSP00000381285, ENSP00000328699, ENSG00000160191, ENSP00000381287, ENSP00000369685, ENSP00000381291, ENSP00000381289, ENST00000328862, ENST00000335512, ENSP00000344730, ENST00000398232, ENST00000398234, ENST00000398236, ENST00000398227, ENST00000398229, ENSP00000335365, ENST00000291539, ENSP00000335242, ENST00000398224, ENST00000398225, ENST00000380328

ZINC - Predictions - Purchasable

PDE9A_HUMAN

HMDB Protein

HMDBP00616

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q49AN0 CRY2	4	p-S-CRY2 [nucleoplasm] (R-HSA-400328) p-S-CRY2 [cytosol] (R-HSA-400305) CRY2 [cytosol] (R-HSA-400255) Ub-p-S-CRY2 [nucleoplasm] (R-HSA-517935)	0.556	3

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