Reactome | PDE8B [cytosol]

PDE8B [cytosol]

Stable Identifier

R-HSA-418531

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Phosphodiesterase 8B, High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B, PDE8B_HUMAN

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (s) signalling events (Homo sapiens)
      - cAMP degradation by Phosphodiesterases (Homo sapiens)
        
        cAMP PDEs [cytosol] (Homo sapiens)
        
        Phosphodiesterases, cyclic AMP-selective [cytosol] (Homo sapiens)
        
        PDE8 [cytosol] (Homo sapiens)
        
        PDE8B [cytosol] (Homo sapiens)

General

cAMP selective hydrolase

External Reference Information

External Reference

UniProt:O95263 PDE8B

Gene Names

PDE8B, PIG22

Chain

chain:1-885

Reference Genes

BioGPS Gene:8622 PDE8B

COSMIC (genes):PDE8B PDE8B

CTD Gene:8622 PDE8B

dbSNP Gene:8622 PDE8B

ENSEMBL:ENSG00000113231 PDE8B

ENSEMBL_homo_sapiens_GENE:ENSG00000113231.14 PDE8B

HGNC:8794 PDE8B

KEGG Gene (Homo sapiens):8622 PDE8B

Monarch:8622 PDE8B

NCBI Gene:8622 PDE8B

OMIM:603390 PDE8B

UCSC:O95263 PDE8B

Reference Transcript

Other Identifiers

11738185_s_at

11738186_a_at

11743088_s_at

1554789_PM_a_at

1554789_a_at

16986501

213228_PM_at

213228_at

235115_PM_at

235115_at

2816685

2816686

2816687

2816693

2816695

2816696

2816698

2816699

2816700

2816704

2816705

2816708

2816717

2816719

2816720

2816721

2816723

2816724

2816725

2816726

2816729

2816731

2816732

2816733

2816734

2816735

2816736

37249_at

61880_at

8106448

8622

A_14_P115922

A_24_P197537

GE54714

GO:0001662

GO:0003824

GO:0004114

GO:0004115

GO:0005575

GO:0005829

GO:0006198

GO:0006629

GO:0007165

GO:0008081

GO:0008542

GO:0016787

GO:0023052

GO:0035106

GO:0046676

GO:0046872

GO:0050877

GO:0050885

GO:0055086

GO:0061179

GO:0090032

GO:1901135

HMNXSV003004905

Hs.120306.0.A1_3p_at

Hs.78106.0.S1_3p_at

Hs2.78106.2.S1_3p_s_at

ILMN_2301722

ILMN_2301725

PH_hs_0004513

TC05000381.hg

Participates

as a member of

PDE8 [cytosol] (Homo sapiens)

Inferred To

Homologues of PDE8B [cytosol] (Dictyostelium discoideum)

Homologues of PDE8B [cytosol] (Plasmodium falciparum)

PDE8B [cytosol] (Bos taurus)

PDE8B [cytosol] (Caenorhabditis elegans)

PDE8B [cytosol] (Canis familiaris)

PDE8B [cytosol] (Dictyostelium discoideum)

PDE8B [cytosol] (Drosophila melanogaster)

PDE8B [cytosol] (Gallus gallus)

PDE8B [cytosol] (Mus musculus)

PDE8B [cytosol] (Plasmodium falciparum)

PDE8B [cytosol] (Rattus norvegicus)

PDE8B [cytosol] (Sus scrofa)

PDE8B [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001025023.1, NP_001025024.1, NP_003710.1, NP_001025025.1, NP_001025022.1

Guide to Pharmacology - Targets

1308

OpenTargets

ENSG00000113231

ZINC - Substances

PDE8B_HUMAN

ZINC target

O95263

PRO

O95263

GeneCards

O95263

HPA

ENSG00000113231-PDE8B

Ensembl

ENSP00000345446, ENSP00000264917, ENSP00000423461, ENST00000333194, ENST00000340978, ENSP00000345646, ENST00000505283, ENSP00000331336, ENST00000342343, ENSG00000113231, ENSP00000330428, ENST00000264917, ENST00000346042

Pharos - Targets

O95263

Orphanet

19022

ZINC - Predictions - Purchasable

PDE8B_HUMAN

HMDB Protein

HMDBP00630