Reactome | PDE8B [cytosol]

PDE8B [cytosol]

Stable Identifier

R-HSA-418531

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Phosphodiesterase 8B, High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B, PDE8B_HUMAN

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (s) signalling events (Homo sapiens)
      - cAMP degradation by Phosphodiesterases (Homo sapiens)
        
        cAMP PDEs [cytosol] (Homo sapiens)
        
        Phosphodiesterases, cyclic AMP-selective [cytosol] (Homo sapiens)
        
        PDE8 [cytosol] (Homo sapiens)
        
        PDE8B [cytosol] (Homo sapiens)

General

cAMP selective hydrolase

External Reference Information

External Reference

UniProt:O95263 PDE8B

Gene Names

PDE8B, PIG22

Chain

chain:1-885

Reference Genes

BioGPS Gene:8622 PDE8B

COSMIC - genes:PDE8B PDE8B

CTD Gene:8622 PDE8B

dbSNP Gene:8622 PDE8B

ENSEMBL:ENSG00000113231 PDE8B

HGNC:8794 PDE8B

KEGG:hsa:8622 PDE8B

Monarch:8622 PDE8B

NCBI Gene:8622 PDE8B

OMIM:603390 PDE8B

UCSC:O95263 PDE8B

Reference Transcript

Other Identifiers

11738185_s_at

11738186_a_at

11743088_s_at

1554789_PM_a_at

1554789_a_at

16986501

213228_PM_at

213228_at

235115_PM_at

235115_at

2816684

2816685

2816686

2816687

2816693

2816694

2816695

2816696

2816697

2816698

2816699

2816700

2816704

2816705

2816706

2816707

2816708

2816717

2816719

2816720

2816721

2816723

2816724

2816725

2816726

2816729

2816731

2816732

2816733

2816734

2816735

2816736

2816800

2816802

37249_at

61880_at

8106448

8622

A_14_P115922

A_24_P197537

GE54714

GO:0001662

GO:0004114

GO:0004115

GO:0005829

GO:0006198

GO:0007165

GO:0008081

GO:0008542

GO:0016787

GO:0035106

GO:0046676

GO:0046872

GO:0047555

GO:0050877

GO:0050885

GO:0055086

GO:0061179

GO:0070374

GO:0090032

GO:0141162

GO:1901135

HMNXSV003004905

Hs.120306.0.A1_3p_at

Hs.78106.0.S1_3p_at

Hs2.78106.2.S1_3p_s_at

ILMN_2301722

ILMN_2301725

PH_hs_0004513

TC05000381.hg

Participates

as a member of

PDE8 [cytosol] (Homo sapiens)

Inferred To

Homologues of PDE8B [cytosol] (Dictyostelium discoideum)

Homologues of PDE8B [cytosol] (Plasmodium falciparum)

PDE8B [cytosol] (Bos taurus)

PDE8B [cytosol] (Caenorhabditis elegans)

PDE8B [cytosol] (Canis familiaris)

PDE8B [cytosol] (Dictyostelium discoideum)

PDE8B [cytosol] (Drosophila melanogaster)

PDE8B [cytosol] (Gallus gallus)

PDE8B [cytosol] (Mus musculus)

PDE8B [cytosol] (Plasmodium falciparum)

PDE8B [cytosol] (Rattus norvegicus)

PDE8B [cytosol] (Saccharomyces cerevisiae)

PDE8B [cytosol] (Sus scrofa)

PDE8B [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001025023.1, NP_001025025.1, NP_003710.1, NP_001025024.1, NP_001025022.1

Guide to Pharmacology - Targets

1308

ENSEMBL

ENSP00000330428, ENST00000342343, ENST00000346042, ENSP00000423461, ENST00000505283, ENSP00000331336, ENSP00000264917, ENST00000264917, ENST00000333194, ENST00000340978, ENSP00000345446, ENSG00000113231, ENSP00000345646

OpenTargets

ENSG00000113231

ZINC - Substances

PDE8B_HUMAN

ZINC target

O95263

PRO

O95263

GeneCards

PDE8B

HPA

ENSG00000113231-PDE8B

Pharos - Targets

O95263

Orphanet

PDE8B

ZINC - Predictions - Purchasable

PDE8B_HUMAN

HMDB Protein

HMDBP00630