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PDE8A [cytosol]
Stable Identifier
R-HSA-418528
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Phosphodiesterase 8A, High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A, PDE8A_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (s) signalling events (Homo sapiens)
cAMP degradation by Phosphodiesterases (Homo sapiens)
cAMP PDEs [cytosol] (Homo sapiens)
Phosphodiesterases, cyclic AMP-selective [cytosol] (Homo sapiens)
PDE8 [cytosol] (Homo sapiens)
PDE8A [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O60658 PDE8A
Gene Names
PDE8A
Chain
chain:1-829
Reference Genes
BioGPS Gene:5151 PDE8A
COSMIC (genes):PDE8A PDE8A
CTD Gene:5151 PDE8A
dbSNP Gene:5151 PDE8A
ENSEMBL:ENSG00000073417 PDE8A
HGNC:8793 PDE8A
KEGG:hsa:5151 PDE8A
Monarch:5151 PDE8A
NCBI Gene:5151 PDE8A
OMIM:602972 PDE8A
UCSC:O60658 PDE8A
Reference Transcript
RefSeq:NM_001243137.1 PDE8A
RefSeq:NM_002605.2 PDE8A
RefSeq:XM_017022311.1 PDE8A
RefSeq:NM_173454.1 PDE8A
Other Identifiers
11719056_s_at
11719057_a_at
11742209_a_at
1552931_PM_a_at
1552931_a_at
16804294
212521_PM_s_at
212521_s_at
212522_PM_at
212522_at
3606035
3606036
3606037
3606040
3606041
3606042
3606065
3606066
3606067
3606068
3606073
3606075
3606079
3606082
3606083
3606084
3606085
3606086
3606089
3606091
3606092
3606093
3606102
3606103
3606106
3606107
3606108
3606109
3606110
3606111
3606112
3606113
3606114
3606115
3606116
3606117
3606118
3606120
3606121
3606122
3606123
3606124
3606131
3606133
3606134
3606135
3606136
3606137
37676_at
5151
7985662
A_14_P108311
A_14_P108873
A_23_P394154
A_33_P3244951
GE54533
GO:0003824
GO:0004114
GO:0004115
GO:0005634
GO:0005829
GO:0006198
GO:0006355
GO:0007165
GO:0008081
GO:0016787
GO:0019900
GO:0019933
GO:0030295
GO:0043226
GO:0046872
GO:0047555
GO:0048471
GO:0055086
GO:0070062
GO:0070374
GO:0071364
GO:0098772
GO:1901135
HMNXSV003018298
HMNXSV003026072
Hs.78746.0.S1_3p_a_at
Hs.78746.0.S2_3p_at
Hs2.78746.1.S1_3p_s_at
ILMN_1657686
ILMN_1699767
ILMN_1824555
ILMN_2295213
ILMN_2408946
PH_hs_0004537
TC15000824.hg
Participates
as a member of
PDE8 [cytosol] (Homo sapiens)
Inferred To
Homologues of PDE8A [cytosol]
(Dictyostelium discoideum)
Homologues of PDE8A [cytosol]
(Plasmodium falciparum)
PDE8A [cytosol]
(Bos taurus)
PDE8A [cytosol]
(Caenorhabditis elegans)
PDE8A [cytosol]
(Canis familiaris)
PDE8A [cytosol]
(Danio rerio)
PDE8A [cytosol]
(Dictyostelium discoideum)
PDE8A [cytosol]
(Drosophila melanogaster)
PDE8A [cytosol]
(Gallus gallus)
PDE8A [cytosol]
(Mus musculus)
PDE8A [cytosol]
(Plasmodium falciparum)
PDE8A [cytosol]
(Rattus norvegicus)
PDE8A [cytosol]
(Sus scrofa)
Cross References
ZINC - World Drugs
PDE8A_HUMAN
Guide to Pharmacology - Targets
1307
ENSEMBL
ENSP00000432309
,
ENST00000478717
,
ENST00000557957
,
ENSP00000378056
,
ENST00000339708
,
ENSP00000453808
,
ENSP00000311453
,
ENST00000394553
,
ENSP00000340679
,
ENST00000310298
OpenTargets
ENSG00000073417
ZINC - FDA approved
PDE8A_HUMAN
ZINC - Substances
PDE8A_HUMAN
ZINC target
O60658
PRO
O60658
PDB
7CWA
,
3ECM
,
7CWF
,
7VSL
,
7VTX
,
7VTV
,
7VTW
,
3ECN
,
7CWG
HPA
ENSG00000073417-PDE8A
Pharos - Targets
O60658
ZINC - Predictions - Purchasable
PDE8A_HUMAN
HMDB Protein
HMDBP00575
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