Reactome | PDE8A [cytosol]

PDE8A [cytosol]

Stable Identifier

R-HSA-418528

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Phosphodiesterase 8A, High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A, PDE8A_HUMAN

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (s) signalling events (Homo sapiens)
      - cAMP degradation by Phosphodiesterases (Homo sapiens)
        
        cAMP PDEs [cytosol] (Homo sapiens)
        
        Phosphodiesterases, cyclic AMP-selective [cytosol] (Homo sapiens)
        
        PDE8 [cytosol] (Homo sapiens)
        
        PDE8A [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O60658 PDE8A

Gene Names

PDE8A

Chain

chain:1-829

Reference Genes

BioGPS Gene:5151 PDE8A

COSMIC (genes):PDE8A PDE8A

CTD Gene:5151 PDE8A

dbSNP Gene:5151 PDE8A

ENSEMBL:ENSG00000073417 PDE8A

ENSEMBL:ENSG00000073417.15 PDE8A

HGNC:8793 PDE8A

KEGG Gene (Homo sapiens):5151 PDE8A

Monarch:5151 PDE8A

NCBI Gene:5151 PDE8A

OMIM:602972 PDE8A

UCSC:O60658 PDE8A

Reference Transcript

Other Identifiers

11719056_s_at

11719057_a_at

11742209_a_at

1552931_PM_a_at

1552931_a_at

16804294

212521_PM_s_at

212521_s_at

212522_PM_at

212522_at

3606035

3606036

3606037

3606040

3606041

3606042

3606066

3606067

3606068

3606073

3606075

3606079

3606082

3606084

3606085

3606086

3606089

3606092

3606093

3606102

3606106

3606107

3606110

3606113

3606114

3606117

3606121

3606122

3606123

3606124

3606131

3606133

3606134

3606135

3606136

3606137

37676_at

5151

7985662

A_14_P108311

A_14_P108873

A_23_P394154

A_33_P3244951

GE54533

GO:0003824

GO:0004114

GO:0004115

GO:0005576

GO:0005615

GO:0005829

GO:0006198

GO:0006351

GO:0006355

GO:0007165

GO:0008081

GO:0016787

GO:0019900

GO:0023052

GO:0030295

GO:0043226

GO:0046872

GO:0047555

GO:0055086

GO:0070062

GO:0070374

GO:0071364

GO:0098772

GO:1901135

HMNXSV003018298

HMNXSV003026072

Hs.78746.0.S1_3p_a_at

Hs.78746.0.S2_3p_at

Hs2.78746.1.S1_3p_s_at

ILMN_1699767

ILMN_1824555

ILMN_2295213

ILMN_2408946

PH_hs_0004537

TC15000824.hg

Participates

as a member of

PDE8 [cytosol] (Homo sapiens)

Inferred To

PDE8A [cytosol] (Bos taurus)

PDE8A [cytosol] (Caenorhabditis elegans)

PDE8A [cytosol] (Canis familiaris)

PDE8A [cytosol] (Danio rerio)

PDE8A [cytosol] (Drosophila melanogaster)

PDE8A [cytosol] (Gallus gallus)

PDE8A [cytosol] (Mus musculus)

PDE8A [cytosol] (Rattus norvegicus)

PDE8A [cytosol] (Saccharomyces cerevisiae)

PDE8A [cytosol] (Sus scrofa)

PDE8A [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

XP_016877800.1, NP_002596.1, NP_775656.1, NP_001230066.1

ZINC - World Drugs

PDE8A_HUMAN

Guide to Pharmacology - Targets

1307

OpenTargets

ENSG00000073417

ZINC - FDA approved

PDE8A_HUMAN

ZINC - Substances

PDE8A_HUMAN

ZINC target

O60658

PRO

O60658

PDB

7VTV, 3ECM, 7VTW, 7CWA, 7VSL, 7CWF, 3ECN, 7VTX, 7CWG

GeneCards

O60658

HPA

ENSG00000073417-PDE8A

Ensembl

ENST00000478717, ENSP00000311453, ENSP00000432309, ENSG00000073417, ENST00000310298, ENSP00000340679, ENST00000339708, ENSP00000378056, ENST00000394553, ENST00000557957, ENSP00000453808

Pharos - Targets

O60658

ZINC - Predictions - Purchasable

PDE8A_HUMAN

HMDB Protein

HMDBP00575