Reactome | PDE1A [cytosol]

PDE1A [cytosol]

Stable Identifier

R-HSA-418501

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Phosphodiesterase 1A, calcium/calmodulin-dependent, Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A, PDE1A_HUMAN

Locations in the PathwayBrowser

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Hemostasis (Homo sapiens)

- Platelet homeostasis (Homo sapiens)
  - Nitric oxide stimulates guanylate cyclase (Homo sapiens)
    - cGMP effects (Homo sapiens)
      - cGMP is degraded by PDEs (Homo sapiens)
        
        cGMP phosphodiesterases [cytosol] (Homo sapiens)
        
        Phosphodiesterases, dual (cAMP, cGMP) activity [cytosol] (Homo sapiens)
        
        PDE1A [cytosol] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Intracellular signaling by second messengers (Homo sapiens)
  - DAG and IP3 signaling (Homo sapiens)
    - CaM pathway (Homo sapiens)
      - Calmodulin induced events (Homo sapiens)
        
        Cam-PDE 1 activation (Homo sapiens)
        
        Calmodulin activates Cam-PDE 1 (Homo sapiens)
        
        PDE1 dimers [cytosol] (Homo sapiens)
        
        Cam-PDE 1A homodimer [cytosol] (Homo sapiens)
        
        PDE1A [cytosol] (Homo sapiens)
- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Opioid Signalling (Homo sapiens)
        
        G-protein mediated events (Homo sapiens)
        
        PLC beta mediated events (Homo sapiens)
        
        Ca-dependent events (Homo sapiens)
        
        CaM pathway (Homo sapiens)
        
        Calmodulin induced events (Homo sapiens)
        
        Cam-PDE 1 activation (Homo sapiens)
        
        Calmodulin activates Cam-PDE 1 (Homo sapiens)
        
        PDE1 dimers [cytosol] (Homo sapiens)
        
        Cam-PDE 1A homodimer [cytosol] (Homo sapiens)
        
        PDE1A [cytosol] (Homo sapiens)
    - G alpha (s) signalling events (Homo sapiens)
      - cAMP degradation by Phosphodiesterases (Homo sapiens)
        
        cAMP PDEs [cytosol] (Homo sapiens)
        
        Phosphodiesterases, dual (cAMP, cGMP) activity [cytosol] (Homo sapiens)
        
        PDE1A [cytosol] (Homo sapiens)

General

Can hydrolyze both cAMP and cGMP

External Reference Information

External Reference

UniProt:P54750 PDE1A

Gene Names

PDE1A

Chain

chain:1-535

Reference Genes

BioGPS Gene:5136 PDE1A

COSMIC (genes):PDE1A PDE1A

CTD Gene:5136 PDE1A

dbSNP Gene:5136 PDE1A

ENSEMBL:ENSG00000115252 PDE1A

HGNC:8774 PDE1A

KEGG Gene (Homo sapiens):5136 PDE1A

Monarch:5136 PDE1A

NCBI Gene:5136 PDE1A

OMIM:171890 PDE1A

UCSC:P54750 PDE1A

Reference Transcript

Other Identifiers

0005290088

0106350309

11733358_a_at

11734814_a_at

1558680_s_at

16906140

208396_s_at

231213_at

233547_x_at

236234_at

242789_at

2590585

2590586

2590587

2590591

2590599

2590600

2590601

2590606

2590607

2590608

2590611

2590612

2590613

2590614

2590615

2590616

2590617

2590618

2590619

2590620

2590628

2590645

2590646

2590661

2590662

2590663

2590664

2590667

2590668

36311_at

49109_at

5136

59445_at

79873_at

8057486

A_23_P79272

A_24_P102082

A_24_P208436

A_24_P208442

GE56445

GO:0003674

GO:0004114

GO:0004117

GO:0005515

GO:0005516

GO:0005575

GO:0005622

GO:0005634

GO:0005737

GO:0005829

GO:0007165

GO:0007186

GO:0008081

GO:0008150

GO:0008219

GO:0008283

GO:0009056

GO:0009058

GO:0016787

GO:0034391

GO:0034641

GO:0034655

GO:0043025

GO:0043167

GO:0043226

GO:0044281

GO:0046069

GO:0046872

GO:0048101

GO:0048660

HMNXSV003002063

HMNXSV003055781

Hs.145173.0.A1_3p_at

Hs.167708.0.S1_3p_at

Hs.22467.0.S1_3p_at

Hs.41717.2.S1_3p_a_at

Hs2.383511.1.S1_3p_s_at

ILMN_1716350

ILMN_1775163

ILMN_1778924

ILMN_1805564

ILMN_2376847

TC02002590.hg

TC02004734.hg

TC02004735.hg

U40370_at

g4826891_3p_a_at

Participates

as a member of

Phosphodiesterases, dual (cAMP, cGMP) activity [cytosol] (Homo sapiens)

as a component of

Cam-PDE 1A homodimer [cytosol] (Homo sapiens)

Other forms of this molecule

activated PDE1A [cytosol]

Inferred To

Pde1a [cytosol] (Mus musculus)

Pde1a [cytosol] (Rattus norvegicus)

pde-1 [cytosol] (Caenorhabditis elegans)

PDE1A [cytosol] (Bos taurus)

PDE1A [cytosol] (Canis familiaris)

PDE1A [cytosol] (Gallus gallus)

PDE1A [cytosol] (Sus scrofa)

PDEgamma [cytosol] (Plasmodium falciparum)

PDEbeta [cytosol] (Plasmodium falciparum)

regA [cytosol] (Dictyostelium discoideum)

pde1a [cytosol] (Danio rerio)

Homologues of activated PDE1A [cytosol] (Plasmodium falciparum)

Pde1c [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

XP_016859785.1, NP_001003683.1, XP_016859789.1, XP_016859784.1, NP_005010.2, XP_016859788.1, XP_016859787.1, XP_016859791.1, XP_016859790.1, NP_001245243.1, NP_001245242.1, XP_016859786.1

ZINC - World Drugs

PDE1A_HUMAN

Guide to Pharmacology - Targets

1294

OpenTargets

ENSG00000115252

ZINC - FDA approved

PDE1A_HUMAN

ZINC - Substances

PDE1A_HUMAN

ZINC target

P54750

ZINC - Biogenic

PDE1A_HUMAN

PRO

P54750

HPA

ENSG00000115252-PDE1A

GeneCards

P54750

Ensembl

ENSP00000387037, ENSP00000386767, ENSP00000309269, ENSP00000410309, ENST00000351439, ENST00000358139, ENSP00000350858, ENSG00000115252, ENST00000409365, ENST00000410103, ENST00000435564

Pharos - Targets

P54750

ZINC - Predictions - Purchasable

PDE1A_HUMAN

HMDB Protein

HMDBP00571