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PDE1A [cytosol]
Stable Identifier
R-HSA-418501
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Phosphodiesterase 1A, calcium/calmodulin-dependent, Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A, PDE1A_HUMAN
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet homeostasis (Homo sapiens)
Nitric oxide stimulates guanylate cyclase (Homo sapiens)
cGMP effects (Homo sapiens)
cGMP is degraded by PDEs (Homo sapiens)
cGMP phosphodiesterases [cytosol] (Homo sapiens)
Phosphodiesterases, dual (cAMP, cGMP) activity [cytosol] (Homo sapiens)
PDE1A [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
DAG and IP3 signaling (Homo sapiens)
CaM pathway (Homo sapiens)
Calmodulin induced events (Homo sapiens)
Cam-PDE 1 activation (Homo sapiens)
Calmodulin activates Cam-PDE 1 (Homo sapiens)
PDE1 dimers [cytosol] (Homo sapiens)
Cam-PDE 1A homodimer [cytosol] (Homo sapiens)
PDE1A [cytosol] (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Opioid Signalling (Homo sapiens)
G-protein mediated events (Homo sapiens)
PLC beta mediated events (Homo sapiens)
Ca-dependent events (Homo sapiens)
CaM pathway (Homo sapiens)
Calmodulin induced events (Homo sapiens)
Cam-PDE 1 activation (Homo sapiens)
Calmodulin activates Cam-PDE 1 (Homo sapiens)
PDE1 dimers [cytosol] (Homo sapiens)
Cam-PDE 1A homodimer [cytosol] (Homo sapiens)
PDE1A [cytosol] (Homo sapiens)
G alpha (s) signalling events (Homo sapiens)
cAMP degradation by Phosphodiesterases (Homo sapiens)
cAMP PDEs [cytosol] (Homo sapiens)
Phosphodiesterases, dual (cAMP, cGMP) activity [cytosol] (Homo sapiens)
PDE1A [cytosol] (Homo sapiens)
General
Can hydrolyze both cAMP and cGMP
External Reference Information
External Reference
UniProt:P54750 PDE1A
Gene Names
PDE1A
Chain
chain:1-535
Reference Genes
BioGPS Gene:5136 P547504
COSMIC (genes):PDE1A PDE1A
CTD Gene:5136 P547504
dbSNP Gene:5136 P547504
ENSEMBL:ENSG00000115252 PDE1A
HGNC:8774 P547504
KEGG:hsa:5136 P547504
Monarch:5136 P547504
NCBI Gene:5136 P547504
OMIM:171890 P547504
UCSC:P54750 P547504
Reference Transcript
RefSeq:XM_017004300.1 P547504
RefSeq:NM_001003683.2 P547504
RefSeq:NM_001258314.1 P547504
RefSeq:XM_017004302.1 P547504
RefSeq:XM_017004296.1 P547504
RefSeq:NM_001258313.1 P547504
RefSeq:NM_005019.4 P547504
RefSeq:XM_017004297.1 P547504
RefSeq:XM_017004299.1 P547504
RefSeq:XM_017004298.1 P547504
RefSeq:XM_017004301.1 P547504
RefSeq:XM_017004295.1 P547504
Participates
as a member of
Phosphodiesterases, dual (cAMP, cGMP) activity [cytosol] (Homo sapiens)
as a component of
Cam-PDE 1A homodimer [cytosol] (Homo sapiens)
Other forms of this molecule
activated PDE1A [cytosol]
Inferred To
Pde1a [cytosol]
(Rattus norvegicus)
PDE1A [cytosol]
(Bos taurus)
PDE1A [cytosol]
(Caenorhabditis elegans)
PDE1A [cytosol]
(Canis familiaris)
PDE1A [cytosol]
(Dictyostelium discoideum)
PDE1A [cytosol]
(Drosophila melanogaster)
PDE1A [cytosol]
(Gallus gallus)
PDE1A [cytosol]
(Mus musculus)
PDE1A [cytosol]
(Plasmodium falciparum)
PDE1A [cytosol]
(Sus scrofa)
PDE1A [cytosol]
(Xenopus tropicalis)
Homologues of PDE1A [cytosol]
(Dictyostelium discoideum)
Homologues of PDE1A [cytosol]
(Plasmodium falciparum)
Cross References
Guide to Pharmacology - Targets
1294
OpenTargets
ENSG00000115252
ENSEMBL
ENSP00000309269
,
ENSP00000386767
,
ENST00000435564
,
ENST00000495511
,
ENSG00000115252
,
ENSP00000512257
,
ENSP00000512258
,
ENSP00000410309
,
ENST00000351439
,
ENST00000409365
,
ENST00000410103
,
ENSP00000387037
,
ENST00000482782
,
ENSP00000350858
,
ENST00000358139
ZINC - FDA approved
PDE1A_HUMAN
ZINC - Substances
PDE1A_HUMAN
ZINC target
P54750
ZINC - Biogenic
PDE1A_HUMAN
PRO
P54750
GlyGen
P54750
HPA
ENSG00000115252-PDE1A
GeneCards
PDE1A
Pharos - Targets
P54750
ZINC - Predictions - Purchasable
PDE1A_HUMAN
HMDB Protein
HMDBP00571
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