Reactome | PDE1A [cytosol]

PDE1A [cytosol]

Stable Identifier

R-HSA-418501

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Phosphodiesterase 1A, calcium/calmodulin-dependent, Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A, PDE1A_HUMAN

Locations in the PathwayBrowser

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Hemostasis (Homo sapiens)

- Platelet homeostasis (Homo sapiens)
  - Nitric oxide stimulates guanylate cyclase (Homo sapiens)
    - cGMP effects (Homo sapiens)
      - cGMP is degraded by PDEs (Homo sapiens)
        
        cGMP phosphodiesterases [cytosol] (Homo sapiens)
        
        Phosphodiesterases, dual (cAMP, cGMP) activity [cytosol] (Homo sapiens)
        
        PDE1A [cytosol] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Intracellular signaling by second messengers (Homo sapiens)
  - DAG and IP3 signaling (Homo sapiens)
    - CaM pathway (Homo sapiens)
      - Calmodulin induced events (Homo sapiens)
        
        Cam-PDE 1 activation (Homo sapiens)
        
        Calmodulin activates Cam-PDE 1 (Homo sapiens)
        
        PDE1 dimers [cytosol] (Homo sapiens)
        
        Cam-PDE 1A homodimer [cytosol] (Homo sapiens)
        
        PDE1A [cytosol] (Homo sapiens)
- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Opioid Signalling (Homo sapiens)
        
        G-protein mediated events (Homo sapiens)
        
        PLC beta mediated events (Homo sapiens)
        
        Ca-dependent events (Homo sapiens)
        
        CaM pathway (Homo sapiens)
        
        Calmodulin induced events (Homo sapiens)
        
        Cam-PDE 1 activation (Homo sapiens)
        
        Calmodulin activates Cam-PDE 1 (Homo sapiens)
        
        PDE1 dimers [cytosol] (Homo sapiens)
        
        Cam-PDE 1A homodimer [cytosol] (Homo sapiens)
        
        PDE1A [cytosol] (Homo sapiens)
    - G alpha (s) signalling events (Homo sapiens)
      - cAMP degradation by Phosphodiesterases (Homo sapiens)
        
        cAMP PDEs [cytosol] (Homo sapiens)
        
        Phosphodiesterases, dual (cAMP, cGMP) activity [cytosol] (Homo sapiens)
        
        PDE1A [cytosol] (Homo sapiens)

General

Can hydrolyze both cAMP and cGMP

External Reference Information

External Reference

UniProt:P54750 PDE1A

Gene Names

PDE1A

Chain

chain:1-535

Reference Genes

BioGPS Gene:5136 P547504

COSMIC (genes):PDE1A PDE1A

CTD Gene:5136 P547504

dbSNP Gene:5136 P547504

ENSEMBL:ENSG00000115252 PDE1A

HGNC:8774 P547504

KEGG:hsa:5136 P547504

Monarch:5136 P547504

NCBI Gene:5136 P547504

OMIM:171890 P547504

UCSC:P54750 P547504

Reference Transcript

Participates

as a member of

Phosphodiesterases, dual (cAMP, cGMP) activity [cytosol] (Homo sapiens)

as a component of

Cam-PDE 1A homodimer [cytosol] (Homo sapiens)

Other forms of this molecule

activated PDE1A [cytosol]

Inferred To

Pde1a [cytosol] (Rattus norvegicus)

PDE1A [cytosol] (Bos taurus)

PDE1A [cytosol] (Caenorhabditis elegans)

PDE1A [cytosol] (Canis familiaris)

PDE1A [cytosol] (Dictyostelium discoideum)

PDE1A [cytosol] (Drosophila melanogaster)

PDE1A [cytosol] (Gallus gallus)

PDE1A [cytosol] (Mus musculus)

PDE1A [cytosol] (Plasmodium falciparum)

PDE1A [cytosol] (Sus scrofa)

PDE1A [cytosol] (Xenopus tropicalis)

Homologues of PDE1A [cytosol] (Dictyostelium discoideum)

Homologues of PDE1A [cytosol] (Plasmodium falciparum)

Cross References

Guide to Pharmacology - Targets

1294

OpenTargets

ENSG00000115252

ENSEMBL

ENSP00000309269, ENSP00000386767, ENST00000435564, ENST00000495511, ENSG00000115252, ENSP00000512257, ENSP00000512258, ENSP00000410309, ENST00000351439, ENST00000409365, ENST00000410103, ENSP00000387037, ENST00000482782, ENSP00000350858, ENST00000358139

ZINC - FDA approved

PDE1A_HUMAN

ZINC - Substances

PDE1A_HUMAN

ZINC target

P54750

ZINC - Biogenic

PDE1A_HUMAN

PRO

P54750

GlyGen

P54750

HPA

ENSG00000115252-PDE1A

GeneCards

PDE1A

Pharos - Targets

P54750

ZINC - Predictions - Purchasable

PDE1A_HUMAN

HMDB Protein

HMDBP00571