Reactome | PDE1A [cytosol]

PDE1A

Stable Identifier

R-HSA-418501

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Phosphodiesterase 1A, calcium/calmodulin-dependent, Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A, PDE1A_HUMAN

Locations in the PathwayBrowser

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Hemostasis (Homo sapiens)

- Platelet homeostasis (Homo sapiens)
  - Nitric oxide stimulates guanylate cyclase (Homo sapiens)
    - cGMP effects (Homo sapiens)
      - cGMP is degraded by PDEs (Homo sapiens)
        
        cGMP phosphodiesterases [cytosol] (Homo sapiens)
        
        Phosphodiesterases, dual (cAMP, cGMP) activity [cytosol] (Homo sapiens)
        
        PDE1A [cytosol] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Intracellular signaling by second messengers (Homo sapiens)
  - DAG and IP3 signaling (Homo sapiens)
    - CaM pathway (Homo sapiens)
      - Calmodulin induced events (Homo sapiens)
        
        Cam-PDE 1 activation (Homo sapiens)
        
        Calmodulin activates Cam-PDE 1 (Homo sapiens)
        
        PDE1 dimers [cytosol] (Homo sapiens)
        
        Cam-PDE 1A homodimer [cytosol] (Homo sapiens)
        
        PDE1A [cytosol] (Homo sapiens)
- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Opioid Signalling (Homo sapiens)
        
        G-protein mediated events (Homo sapiens)
        
        PLC beta mediated events (Homo sapiens)
        
        Ca-dependent events (Homo sapiens)
        
        CaM pathway (Homo sapiens)
        
        Calmodulin induced events (Homo sapiens)
        
        Cam-PDE 1 activation (Homo sapiens)
        
        Calmodulin activates Cam-PDE 1 (Homo sapiens)
        
        PDE1 dimers [cytosol] (Homo sapiens)
        
        Cam-PDE 1A homodimer [cytosol] (Homo sapiens)
        
        PDE1A [cytosol] (Homo sapiens)
    - G alpha (s) signalling events (Homo sapiens)
      - cAMP degradation by Phosphodiesterases (Homo sapiens)
        
        cAMP phosphodiesterases [cytosol] (Homo sapiens)
        
        Phosphodiesterases, dual (cAMP, cGMP) activity [cytosol] (Homo sapiens)
        
        PDE1A [cytosol] (Homo sapiens)

Summation

Can hydrolyze both cAMP and cGMP

External Reference Information

External Reference

UniProt:P54750 PDE1A

Gene Names

PDE1A

Chain

chain:1-535

Reference Genes

BioGPS Gene:5136 PDE1A

COSMIC (genes):PDE1A PDE1A

CTD Gene:5136 PDE1A

dbSNP Gene:5136 PDE1A

ENSEMBL:ENSG00000115252 PDE1A

HGNC:8774 PDE1A

KEGG Gene (Homo sapiens):hsa:5136 PDE1A

Monarch:5136 PDE1A

NCBI Gene:5136 PDE1A

OMIM:171890 PDE1A

UCSC:P54750 PDE1A

Reference Transcript

Other Identifiers

0005290088

00230+3.1.4.17

0106350309

11733358_a_at

11734814_a_at

1558680_s_at

16906140

1LXQ

208396_s_at

22151

231213_at

233547_x_at

236234_at

242789_at

2590585

2590586

2590587

2590591

2590599

2590600

2590601

2590606

2590607

2590608

2590611

2590612

2590613

2590614

2590615

2590616

2590617

2590618

2590619

2590620

2590628

2590645

2590646

2590661

2590662

36311_at

49109_at

5136

59445_at

79873_at

8057486

A_23_P79272

A_24_P102082

A_24_P208436

A_24_P208442

AAC50436

AAH22480

AB038224

AJ401610

AL110263

BAB20049

BAB20050

BAB20051

BAB20052

BAB20053

BAB20054

BAB20055

BAB20056

BAB20057

BC022480

CAB53703

CAC82208

CCDS2285

CCDS33344

CCDS58741

CCDS74612

CH471058

EAX10966

EAX10974

ENSG00000115252

ENSP00000309269

ENSP00000350858

ENSP00000386767

ENSP00000387037

ENSP00000410309

ENST00000351439

ENST00000358139

ENST00000409365

ENST00000410103

ENST00000435564

EntrezGene:5136

g4826891_3p_a_at

GE56445

GO:0003674

GO:0004114

GO:0004115

GO:0004117

GO:0005516

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005737

GO:0005829

GO:0007165

GO:0007186

GO:0008081

GO:0008150

GO:0008219

GO:0008283

GO:0009056

GO:0009058

GO:0016787

GO:0034391

GO:0034641

GO:0034655

GO:0043025

GO:0043167

GO:0043226

GO:0044281

GO:0046069

GO:0046872

GO:0047555

GO:0048101

GO:0048660

HGNC:8774

HPA022151

Hs.145173.0.A1_3p_at

Hs.167708.0.S1_3p_at

Hs.22467.0.S1_3p_at

Hs.41717.2.S1_3p_a_at

Hs2.383511.1.S1_3p_s_at

ILMN_1716350

ILMN_1775163

ILMN_1778924

ILMN_1805564

ILMN_2376847

IPR002073

IPR003607

IPR013706

IPR023088

IPR023174

IPR036971

MIM:171890

NM_001003683

NM_001258312

NM_001258313

NM_001258314

NM_005019

NP_001003683

NP_001245241

NP_001245242

NP_001245243

NP_005010

PDE1A

PDE1A-201

PDE1A-202

PDE1A-203

PDE1A-204

PDE1A-205

PF00233

PF08499

PR00387

SM00471

TC02002590.hg

TC02004734.hg

TC02004735.hg

U40370

U40370_at

uc002uoq.3

uc002uor.4

uc002uos.5

uc002uou.4

uc061qjq.1

UPI0000001072

UPI000002A6C1

UPI000002A6C2

UPI000003B33F

UPI00000737DB

XM_011511323

XM_011511324

XM_011511325

XM_011511326

XM_017004294

XM_017004295

XM_017004296

XM_017004297

XM_017004298

XM_017004299

XM_017004300

XM_017004301

XM_017004302

XP_011509625

XP_011509626

XP_011509627

XP_011509628

XP_016859783

XP_016859784

XP_016859785

XP_016859786

XP_016859787

XP_016859788

XP_016859789

XP_016859790

XP_016859791

XR_001738769

Participant Of

hasMember

Phosphodiesterases, dual (cAMP, cGMP) activity [cytosol]

hasComponent

Cam-PDE 1A homodimer [cytosol]

Other forms of this molecule

activated PDE1A [cytosol]

Inferred To

activated PDE1A [cytosol] (Bos taurus)

activated PDE1A [cytosol] (Caenorhabditis elegans)

activated PDE1A [cytosol] (Canis familiaris)

activated PDE1A [cytosol] (Danio rerio)

activated PDE1A [cytosol] (Drosophila melanogaster)

activated PDE1A [cytosol] (Gallus gallus)

activated PDE1A [cytosol] (Mus musculus)

activated PDE1A [cytosol] (Rattus norvegicus)

activated PDE1A [cytosol] (Sus scrofa)

activated PDE1A [cytosol] (Taeniopygia guttata)

activated PDE1A [cytosol] (Xenopus tropicalis)

Homologues of activated PDE1A [cytosol] (Canis familiaris)

Homologues of activated PDE1A [cytosol] (Danio rerio)

Homologues of activated PDE1A [cytosol] (Mus musculus)

Homologues of activated PDE1A [cytosol] (Rattus norvegicus)

Homologues of activated PDE1A [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_005010.2, XP_016859786.1, XP_016859788.1, XP_016859789.1, XP_016859785.1, NP_001003683.1, XP_016859787.1, XP_016859790.1, NP_001245242.1, NP_001245243.1, XP_016859791.1, XP_016859784.1

ZINC - World Drugs

PDE1A_HUMAN

ZINC - FDA approved

PDE1A_HUMAN

ZINC - Substances

PDE1A_HUMAN

GeneCards

P54750

ZINC target

P54750

ZINC - Biogenic

PDE1A_HUMAN

PRO

P54750

BRENDA (Homo sapiens)

3.1.4.17

ZINC - Predictions - Purchasable

PDE1A_HUMAN

PDB

1LXQ

HMDB Protein

HMDBP00571