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PDE1A [cytosol]
Stable Identifier
R-HSA-418501
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Phosphodiesterase 1A, calcium/calmodulin-dependent, Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A, PDE1A_HUMAN
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet homeostasis (Homo sapiens)
Nitric oxide stimulates guanylate cyclase (Homo sapiens)
cGMP effects (Homo sapiens)
cGMP is degraded by PDEs (Homo sapiens)
cGMP phosphodiesterases [cytosol] (Homo sapiens)
Phosphodiesterases, dual (cAMP, cGMP) activity [cytosol] (Homo sapiens)
PDE1A [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
DAG and IP3 signaling (Homo sapiens)
CaM pathway (Homo sapiens)
Calmodulin induced events (Homo sapiens)
Cam-PDE 1 activation (Homo sapiens)
Calmodulin activates Cam-PDE 1 (Homo sapiens)
PDE1 dimers [cytosol] (Homo sapiens)
Cam-PDE 1A homodimer [cytosol] (Homo sapiens)
PDE1A [cytosol] (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Opioid Signalling (Homo sapiens)
G-protein mediated events (Homo sapiens)
PLC beta mediated events (Homo sapiens)
Ca-dependent events (Homo sapiens)
CaM pathway (Homo sapiens)
Calmodulin induced events (Homo sapiens)
Cam-PDE 1 activation (Homo sapiens)
Calmodulin activates Cam-PDE 1 (Homo sapiens)
PDE1 dimers [cytosol] (Homo sapiens)
Cam-PDE 1A homodimer [cytosol] (Homo sapiens)
PDE1A [cytosol] (Homo sapiens)
G alpha (s) signalling events (Homo sapiens)
cAMP degradation by Phosphodiesterases (Homo sapiens)
cAMP PDEs [cytosol] (Homo sapiens)
Phosphodiesterases, dual (cAMP, cGMP) activity [cytosol] (Homo sapiens)
PDE1A [cytosol] (Homo sapiens)
General
Can hydrolyze both cAMP and cGMP
External Reference Information
External Reference
UniProt:P54750 PDE1A
Gene Names
PDE1A
Chain
chain:1-535
Reference Genes
BioGPS Gene:5136 PDE1A
COSMIC (genes):PDE1A PDE1A
CTD Gene:5136 PDE1A
dbSNP Gene:5136 PDE1A
ENSEMBL:ENSG00000115252 PDE1A
HGNC:8774 PDE1A
KEGG Gene (Homo sapiens):5136 PDE1A
Monarch:5136 PDE1A
NCBI Gene:5136 PDE1A
OMIM:171890 PDE1A
UCSC:P54750 PDE1A
Reference Transcript
RefSeq:NM_005019.4 PDE1A
RefSeq:XM_017004298.1 PDE1A
RefSeq:XM_017004302.1 PDE1A
RefSeq:NM_001003683.2 PDE1A
RefSeq:XM_017004295.1 PDE1A
RefSeq:XM_017004299.1 PDE1A
RefSeq:NM_001258313.1 PDE1A
RefSeq:XM_017004296.1 PDE1A
RefSeq:XM_017004300.1 PDE1A
RefSeq:NM_001258314.1 PDE1A
RefSeq:XM_017004297.1 PDE1A
RefSeq:XM_017004301.1 PDE1A
Other Identifiers
0005290088
0106350309
11733358_a_at
11734814_a_at
1558680_s_at
16906140
208396_s_at
231213_at
233547_x_at
236234_at
242789_at
2590585
2590586
2590587
2590591
2590599
2590600
2590601
2590606
2590607
2590608
2590611
2590612
2590613
2590614
2590615
2590616
2590617
2590618
2590619
2590620
2590628
2590645
2590646
2590661
2590662
2590663
2590664
2590667
2590668
36311_at
49109_at
5136
59445_at
79873_at
8057486
A_23_P79272
A_24_P102082
A_24_P208436
A_24_P208442
GE56445
GO:0003674
GO:0004114
GO:0004117
GO:0005515
GO:0005516
GO:0005575
GO:0005622
GO:0005634
GO:0005737
GO:0005829
GO:0007165
GO:0007186
GO:0008081
GO:0008150
GO:0008219
GO:0008283
GO:0009056
GO:0009058
GO:0016787
GO:0034391
GO:0034641
GO:0034655
GO:0043025
GO:0043167
GO:0043226
GO:0044281
GO:0046069
GO:0046872
GO:0048101
GO:0048660
HMNXSV003002063
HMNXSV003055781
Hs.145173.0.A1_3p_at
Hs.167708.0.S1_3p_at
Hs.22467.0.S1_3p_at
Hs.41717.2.S1_3p_a_at
Hs2.383511.1.S1_3p_s_at
ILMN_1716350
ILMN_1775163
ILMN_1778924
ILMN_1805564
ILMN_2376847
TC02002590.hg
TC02004734.hg
TC02004735.hg
U40370_at
g4826891_3p_a_at
Participates
as a member of
Phosphodiesterases, dual (cAMP, cGMP) activity [cytosol] (Homo sapiens)
as a component of
Cam-PDE 1A homodimer [cytosol] (Homo sapiens)
Other forms of this molecule
activated PDE1A [cytosol]
Inferred To
Pde1a [cytosol]
(Mus musculus)
Pde1a [cytosol]
(Rattus norvegicus)
pde-1 [cytosol]
(Caenorhabditis elegans)
PDE1A [cytosol]
(Bos taurus)
PDE1A [cytosol]
(Canis familiaris)
PDE1A [cytosol]
(Gallus gallus)
PDE1A [cytosol]
(Sus scrofa)
PDEgamma [cytosol]
(Plasmodium falciparum)
PDEbeta [cytosol]
(Plasmodium falciparum)
regA [cytosol]
(Dictyostelium discoideum)
pde1a [cytosol]
(Danio rerio)
Homologues of activated PDE1A [cytosol]
(Plasmodium falciparum)
Pde1c [cytosol]
(Drosophila melanogaster)
Cross References
RefSeq
XP_016859785.1
,
NP_001003683.1
,
XP_016859789.1
,
XP_016859784.1
,
NP_005010.2
,
XP_016859788.1
,
XP_016859787.1
,
XP_016859791.1
,
XP_016859790.1
,
NP_001245243.1
,
NP_001245242.1
,
XP_016859786.1
ZINC - World Drugs
PDE1A_HUMAN
Guide to Pharmacology - Targets
1294
OpenTargets
ENSG00000115252
ZINC - FDA approved
PDE1A_HUMAN
ZINC - Substances
PDE1A_HUMAN
ZINC target
P54750
ZINC - Biogenic
PDE1A_HUMAN
PRO
P54750
HPA
ENSG00000115252-PDE1A
GeneCards
P54750
Ensembl
ENSP00000387037
,
ENSP00000386767
,
ENSP00000309269
,
ENSP00000410309
,
ENST00000351439
,
ENST00000358139
,
ENSP00000350858
,
ENSG00000115252
,
ENST00000409365
,
ENST00000410103
,
ENST00000435564
Pharos - Targets
P54750
ZINC - Predictions - Purchasable
PDE1A_HUMAN
HMDB Protein
HMDBP00571
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