Reactome | PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release

PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release

Stable Identifier

R-HSA-418442

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, platelet dense tubular network membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

IRAG, PKG1(cGKI), and IP3 receptor type 1 can be isolated as a complex in human platelets. Phosphorylation of IRAG by PKG1 inhibits IP3 receptor-mediated Ca2+ release, representing the primary mechanism by which NO suppresses platelet activation.

Literature References

PubMed ID	Title	Journal	Year
16990611	IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation and thrombus formation Antl, M, von Brühl, ML, Eiglsperger, C, Werner, M, Konrad, I, Kocher, T, Wilm, M, Hofmann, F, Massberg, S, Schlossmann, J	Blood	2007