PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release

Stable Identifier
R-HSA-418442
Type
Reaction [transition]
Species
Homo sapiens
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IRAG, PKG1(cGKI), and IP3 receptor type 1 can be isolated as a complex in human platelets. Phosphorylation of IRAG by PKG1 inhibits IP3 receptor-mediated Ca2+ release, representing the primary mechanism by which NO suppresses platelet activation.

Literature References
PubMed ID Title Journal Year
16990611 IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation and thrombus formation

Antl, M, von Brühl, ML, Eiglsperger, C, Werner, M, Konrad, I, Kocher, T, Wilm, M, Hofmann, F, Massberg, S, Schlossmann, J

Blood 2007
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
cGMP-dependent protein kinase activity of Cyclic GMP-dependent protein kinases (PKGs) [cytosol]
Physical Entity
Activity
Orthologous Events
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Created
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